Clinical trials: Modification
Hypothermia
Study to Determine the Effects of Pre-warming on OR Patient Temperatures and Surgical Outcomes
The application of active warming to patients whether awake or under general anesthesia has been proven safe in numerous studies and it is common practice to use warmers.
- Trial name
- NCT02177903
- Testing
- Bair Paws Patient Adjustable Warming System
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Solventum US LLC
Obesity, Osteoporosis
Milk Supplementation and Energy Balance.
The aim of the project is to determine if milk supplementation during a caloric restriction program facilitates the lost of weight, improves the appetite control and attenuates the decrease of bone mineral content in low-calcium…
- Trial name
- NCT00729170
- Testing
- Supplementation of milk (35% more calcium)
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Laval University
Fever, Chest Tightness
Sulfamethoxazole Prophylaxis Duration After Renal Transplantation
Renal transplantation is the most ideal and effective treatment for end-stage renal disease. Pneumocystis jirovecii pneumonia (PJP) is one of the most common pulmonary infections after renal transplantation, with high morbidity…
- Trial name
- SPDART (NCT07231770)
- Testing
- Time-driven dosing
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Anhui Provincial Hospital
Low-grade Glioma
Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas
This is a Pilot, multicenter, open-label study of patients less than or equal to 25 years, with recurrent or progressive LGG harboring a CRAF or BRAF alteration, including BRAF V600 mutations and KIAA1549: BRAF fusions.
- Trial name
- VICTORY (NCT06381570)
- Testing
- Tovorafenib, Vinblastine
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- Daniel Morgenstern
Pulmonary Emphysema in Alpha-1 PI Deficiency
Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)
This is a multi-center, randomized, placebo-controlled, double blind clinical study to assess the efficacy and safety of two separate dose regimens of Alpha-1 MP versus placebo for 156 weeks (i.e., 3 years) using computed…
- Trial name
- SPARTA (NCT01983241)
- Testing
- Alpha-1 MP, 0.9% Sodium Chloride for Injection, USP
- Where
- 52 sites in United States, Argentina and 15 more
- Volunteers
- 345 people
- Sponsor
- Grifols Therapeutics LLC
Healthy Participants
Randomized Controlled Trial of ADAPT
This trial examines the effectiveness of a novel neurodevelopmentally informed intervention - Adolescent Developmentally-Appropriate health Promotion Therapy (ADAPT) - on preventing alcohol use and promoting well-being among…
- Trial name
- NCT07132866
- Testing
- ADAPT
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- University of Aarhus
Cholelithiasis
Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy
Propofol is one of the most commonly used anesthetic agents because of its ability to induce rapid and reliable collection. However, hypotension and injection pain in the induction are the most common complications.
- Trial name
- lap (NCT03180229)
- Testing
- Granisetron 1 Mg/mL Intravenous Solution
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Osteoporosis
CR9112792, a Follow-up of Study CR9108963
The purpose of this study is to determine whether bone mineral density has increased in a subgroup of postmenopausal osteoporotic women from study CR9108963, between 6 and 12 months following cessation of ronacaleret therapy.
- Trial name
- NCT00891553
- Testing
- DXA
- Where
- 3 sites in Denmark, Norway
- Volunteers
- 171 people
- Sponsor
- GlaxoSmithKline
Obesity
Association Between the Change of the Genes With Hormones and Food Consumption of Obese
Obesity is considered one of the most troubling chronic diseases for public health because of its rapid growth in the population.
- Trial name
- NCT02598037
- Testing
- Test meal
- Where
- Brazil
- Volunteers
- 71 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Spinal; Nerve Root, Pain, Pelvic Pain
Quality of Life and Pain Changes Due to DRG Stimulation for Chronic Pain
ACTIVE study- a prospective observational clinical study examining the changes in quality of life and pain following dorsal root ganglion stimulation for the treatment of chronic intractable pelvic and lower limb pain.
- Conditions
- Spinal; Nerve Root, Pain, Pelvic Pain, Regional Pain Syndrome, Chronic Pain Syndrome
- Trial name
- ACTIVE (NCT03417973)
- Testing
- dorsal root ganglion neuromodulation
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- KM Clinical Research Group
Maxillary Hypoplasia
Skeletal and Dental Changes with Hyrax-type Rapid Maxillary Expander Anchored to Permanent Versus Deciduous Molars
The aim of the study is to compare the skeletal and dental maxillary expansion obtained with an Hyrax tooth-borne expander anchored either on the 2nd deciduous molars (V) or on the 1st permanent molars (6)
- Trial name
- DENTHYRAX (NCT05773573)
- Testing
- Experimental group, Control group
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Type 2
Consultations in Adapted Physical Activity on Behaviours in Physical Exercise by Type 2 Diabetics
Assesment the impact of three individuals consultations in adapted physical activity by type 2 diabetics
- Trial name
- NCT00403741
- Testing
- motivational interviewing
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Alcohol Use Disorder
Neural Mechanisms of Change During the Treatment of Alcohol Use Disorders With Prazosin
The study uses neurobiological measures through brain imaging, neuropsychological measures, and selfreport measures to try to understand how an effective treatment for alcoholism works.
- Trial name
- NCT01916941
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of New Mexico
Obesity
Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss
It is unknown whether the bile acid pathway reacts differently to weight loss resulting from Roux-En-Y Gastric Bypass (RYGB) surgery than weight loss resulting from caloric restriction alone.
- Trial name
- NCT03238794
- Testing
- Roux-En-Y Gastric Bypass, Low-calorie Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Spondyloarthritis
Performance of EOS Imaging System in the Assessment of Spondyloarthritis Structural Changes Compared With Standard Radiography
Spondyloarthritis is a chronic rheumatic disease that requires prolonged radiographic follow-up. This repetitive exposure to ionizing radiation puts at risk the radiosensitive organs exposed in the field of irradiation.
- Trial name
- NCT03863756
- Testing
- EOS
- Where
- Tunisia
- Volunteers
- 75 people
- Sponsor
- Faculty of Medicine of Tunis
Type 2 Diabetes
Blood Glucose Monitoring on Behavior Change in Type 2 Diabetes
This purpose of this study is to investigate the effect of the self-regulation mode of continuous blood glucose monitoring on blood glucose indicators, self-efficacy, health-promoting behaviors, and medication compliance in…
- Trial name
- NCT05367622
- Testing
- Self-regulation health education, Usual diabetes health education
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University of Science and Technology
Braest Cancer, Dry Eye
Corneal Changes in Estrogen-Dependent Breast Cancer After Hormonal Treatment
Aromatase inhibitors (AI) therapy is the treatment of choice for estrogen receptor-positive breast cancer (BC). While AIs effectively suppress tumor growth, estrogen deprivation may have negative impacts on the eyes.
- Trial name
- breast cancer (NCT06924229)
- Testing
- Hormonal treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Body Weight Changes
Effect of the Administration of L-Carnitine on Body Weight in Women in Crossfit Training
The L-carnitine has demonstrated effects in the treatment of obesity mainly promoting the fat degradation during exercise.
- Trial name
- NCT03436277
- Testing
- L-Carnitine, Sucralose
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Maxillary Expansion
Rapid Maxillary Expansion Related Oxidative Stress and Periodontal Results
The aim of this study was to investigate the effects of rapid maxillary expansion on local and systemic oxidative stress levels.
- Trial name
- NCT06937775
- Testing
- Periodontal measurements (plaque index, gingival index and probing pocket depth scores ), Biochemical Sample Supply (Collection of serum and saliva samples), Rapid maxillary expansion with Hyrax appliance
- Volunteers
- 35 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Overweight and Obesity
Could a Time-restricted Diet Compete With a Calorie-restricted 6-meal Diet?
The prevalence of obesity and obesity-related diseases are on the rise worldwide. The widely accepted approach in dietary treatment of obesity is the calorie-restricted three meals-three snacks a day diet; however, alternative…
- Trial name
- NCT06364475
- Testing
- 16:8 Time-Restricted Intermittent Fasting Group, Energy-Restricted Six-Meal Group
- Where
- Turkey (Türkiye)
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
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