Clinical trials: Modification
Birth Weight, Weight Gain Trajectory
Effects of Monitoring Blood Pressure During Pregnancy
In this study, at least 400 women with high-risk of pregnancy hypertension will use a wearable device to monitor the blood pressure during gestational age from 12 weeks to 28weeks.
- Trial name
- NCT06217913
- Testing
- wearable device to monitor the blood pressure
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Chemotherapy-induced Peripheral Neuropathy (CIPN)
PREventing CHemotherapy Induced Neuropathy (PreChIN)
The project is designed to study the use of localized hypothermia alone, or with compression to the limbs during chemotherapy infusion for the prevention of chemotherapy induced peripheral neuropathy (CIPN).
- Trial name
- NCT03299582
- Testing
- Hypothermia, Cryocompression
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Head and Neck Cancer Patients, Lean Body Mass
Lean Body Mass in Head and Neck Cancer Patients During Cisplatin-based Chemoradiation
The goal of this clinical trial is to investigate the changes in body composition in head and neck cancer patients during treatment.
- Conditions
- Head and Neck Cancer Patients, Lean Body Mass, Body Composition Changes
- Trial name
- NCT05890859
- Testing
- DXA scan, Physical testing
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Department of Public Health, Denmark
Patients With Spontaneous Rupture of the Fetal Membranes
Kinetics of Inflammation Markers in Maternal Plasma: Study of the Correlation With the Diagnosis of Chorioamnionitis in Women Hospitalized for Spontaneous Rupture of the Fetal Membranes
The principal aim of this study is to help obstetricians to diagnose chorioamniotic infection early, in cases of premature rupture of the fetal membranes before 34 WA, by proposing earlier and more specific markers of infection…
- Trial name
- NCT01903759
- Testing
- Blood samples
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Weight Loss, Obesity
A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women
The purpose of the trial is to assess the effects of combining regular, generous intakes of high quality protein (primarily from lean pork and other animal source proteins) with calorie restriction on functional status and lean…
- Trial name
- POWR-UP (NCT02033655)
- Testing
- Protein supplementation, Diet counseling and group education lessons
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Duke University
Malignant Hyperthermia
Effectiveness of Carbon Filters to Reduce the Anesthetic Gas Concentration in an Anesthetized Patient
Malignant hyperthermia is a potentially fatal inherited disorder triggered by exposure to volatile anesthetic gases, most commonly recognized in children during anesthesia. Carbon filters have been used to scavenge various gases.
- Trial name
- NCT01624558
- Testing
- In-line Carbon filter (Vapor-Clean)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Stress, Coping
Evaluating Knowledge Mobilization Sustainability Approaches
The overarching objective of the current study is to evaluate the effectiveness, acceptability, strategy use, and maintenance of behaviour change of different stress management sustainability groups.
- Conditions
- Stress, Coping, Well-being, Mindfulness
- Trial name
- NCT07242378
- Testing
- Sustainability of stress management strategy use, Stress management
- Where
- Canada
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- McGill University
Low Flow Anesthesia
Changes in Quality of Recovery With Low-Flow Anesthesia (QoRinLowflow)
Postoperative recovery quality is as important as patient satisfaction and clinical results in terms of a fast and high-quality surgical process.
- Trial name
- (QoRLowflow (NCT05773417)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Acibadem University
Intimate Partner Violence (IPV), Climate Change
Smartphone Climate Adaptation and IPV Intervention for Women in Informal Settlements in Kenya
This study is testing a smartphone-delivered program to help women living in informal settlements in Kenya manage intimate partner violence (IPV) and stress related to extreme weather events.
- Conditions
- Intimate Partner Violence (IPV), Climate Change, Stress (Psychology)
- Trial name
- NCT07492368
- Testing
- Event-Triggered WINGS-Based EMI, Single-Session Mobile WINGS
- Where
- Kenya
- Volunteers
- 272 people
- Sponsor
- Africa Institute of Mental and Brain Health (AFRIMEB)
Diet Modification
A Home-based Intervention to Improve the Diet Quality of Preschoolers
U.S. children eat too little fruits and vegetables and whole grains, and too many energy dense foods, dietary behaviors associated with increased morbidity from cardiovascular diseases.
- Trial name
- NCT03923491
- Testing
- Healthy Feeding, Healthy Eating, Reading Readiness
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Changes in Olfactory Behavior Across Different Contexts Associated With Different Amygdala Subregions
Characterization of Human Olfactory Amygdala Subregions exp2
We aim to better understand the functions of the subregions of the human amygdala that receive direct projections from the olfactory bulb
- Trial name
- NCT07074574
- Testing
- Present odors to participants while recording brain activity using fMRI
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Healthy
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
Bioavailability and food effect of 2 formulations of PF-06650833 in healthy volunteers.
- Trial name
- NCT03308110
- Testing
- PF-06650833
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Parkinson Disease (PD), Gut Microbiota
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor…
- Conditions
- Parkinson Disease (PD), Gut Microbiota, Probiotic
- Trial name
- NCT07619560
- Testing
- Y7
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
Rickettsial Disease
Causes of Fever in Bangladeshi Patients
Background: The clinical features and prevalence of tropical rickettsial illnesses such as murine and scrub typhus in Bangladesh are unknown.
- Trial name
- NCT02339259
- Testing
- Observation
- Where
- Bangladesh
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Anxiety Disorders, Depression
Process and Outcomes in CBT for Anxious and Depressed Youth
The current study will evaluate the predictors, mediators, outcomes, and critical therapy processes associated with manual-based psychological therapies for 400 youth (ages 7-16 years) with anxiety and/or depression seeking…
- Trial name
- NCT03100279
- Testing
- Coping Cat/CAT Project, Primary and Secondary Coping Enhancement Therapy
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Rutgers University
Leukaemia,Lymphoblastic
Modified MRCUKALLⅫ/ECOGE2993 Regimen for ALL
This prospective study was conducted to evaluate the efficacy and safety profiles of Modified MRCUKALLⅫ/ECOGE2993 Regimen in young adults with newly diagnosed, low-risk, Philadelphia chromosome negative acute lymphoblastic…
- Trial name
- NCT02660762
- Testing
- Vincristine, Daunorubicin, Pegaspargase
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Major Depressive Disorder, Inflammation
The Relations Among Endotoxin, Inflammatory Cytokines, Cognitive Markers and Brain MRI Changes in Subjects With Depressive Disorder
Major depressive disorder (MDD) is a chronic mental illness, with 60% lifetime risk of recurrence after the first MDD episode. Despite available treatment options for MDD, only about half to two-thirds of patients respond to…
- Conditions
- Major Depressive Disorder, Inflammation, Cognitive Dysfunction, Endotoxemia
- Trial name
- NCT06203015
- Testing
- The Cambridge Neuropsychological Test Automated Battery., Venous blood samples, brain MRI
- Where
- 2 sites in Lithuania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Fibroids
Endometrial and Myometrial Changes, With and Without Fibroids
fibroids are common among women in fertile age. the relation between fibroids and infertility is controversial. our goal is to claculate a ratio between uterine cavity - endometrium \& myometrium in normal uterine s and study the…
- Trial name
- NCT01671215
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Meir Medical Center
Prediabetic State
Effectiveness of a Nurse-led Personalized Telephone Intervention on Lifestyle Changes in Diabetes Prevention.
A randomized, 9-months, parallel-group study comparing the effectiveness of a nurse-led telephone personalized lifestyle intervention versus automated SMSs on nutritional and physical activity advice in the reduction of fasting…
- Trial name
- PREDIPHONE (NCT04735640)
- Testing
- nurse-led teleconsultation, SMS
- Where
- Spain
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands
PDAC
Master Protocol of TCR-modified T Cell Therapy Targeting HLA-restricted KRAS Antigen Administered in Adult Patients With Metastatic or Locally Advanced PDAC
This is an open-label, multi-centre, single-arm Phase 1/2 clinical trial of the safety, expansion, persistence and clinical activity of a set of engineered autologous T cells products each capable of recognizing a specific…
- Trial name
- NCT07145450
- Testing
- ANOC-001 (TCR-T cells targeting KRAS G12V mutation presented by specific HLA alleles), ANOC-002 (TCR-T cells targeting KRAS G12V mutation presented by specific HLA alleles), ANOC-003 (TCR-T cells targeting KRAS G12D mutation presented by specific HLA alleles)
- Where
- 10 sites in Denmark, Germany and 2 more
- Volunteers
- 96 people
- Sponsor
- Anocca AB
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