Clinical trials: Modification
Pregnancy Related
Daily Step Count and Achieving Goal Gestational Weight Gain
The purpose of this voluntary research study is to determine an optimal step count that aids in achieving the recommended weight gain during pregnancy and to use this count in future studies.
- Trial name
- NCT04605406
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Locally Advanced Thoracic Middle-lower Segment Esophageal Squamous Cell Carcinoma
Changes in Tumor Tissue and Serum Biomarkers Before and After Cetuximab Combined With Preoperative Radiotherapy in Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
This study aim to investigate Changes in tumor tissue and serum biomarkers before and after cetuximab combined with preoperative radiotherapy in locally advanced thoracic middle-lower segment esophageal squamous cell carcinoma.We…
- Trial name
- NCT02123381
- Testing
- preoperative radiotherapy, cetuximab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Clinically Amyopathic Dermatomyisitis(CAMD)
Correlation Between the Change of Peripheral Lymphocyte Subsets and Clinically Amyopathic Dermatomyositis Combined With Rapidly Progressive Interstitial Lung Disease
Acute respiratory distress syndrome (ARDS) occurs in Clinically Amyopathic Dermatomyisitis(CADM) combined with Rapidly Progressive Interstitial Lung Disease(RPILD) within 1-3 months, which leads to death of patients and is…
- Trial name
- NCT04613219
- Testing
- Tofacitinib 5 MG [Xeljanz]
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jing Liang
Pregnancy
Hormonal Changes in Early Pregnancy
This study will analyze hormones in early pregnancy. Hormonal changes in early pregnancy reflect the quality of implantation in the uterus of the fertilized egg, the function of the corpus luteum (mass of hormone-secreting tissue…
- Trial name
- NCT00340028
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Soft Tissue Sarcoma
Hyperthermia and Proton Therapy in Unresectable Soft Tissue Sarcoma
This is a multi-institutional phase I/II clinical trial with concomitant local hyperthermia and proton beam radiotherapy in patients with primary or recurrent unresectable soft tissue sarcomas of the extremities, trunk…
- Trial name
- HYPROSAR (NCT01904565)
- Testing
- Hyperthermia and Proton Beam
- Where
- Switzerland
- Volunteers
- 26 people
- Sponsor
- Kantonsspital Aarau
Non-alcoholic Fatty Liver Disease (NAFLD), Weight Loss
Comparing Effects of Liraglutide and Bariatric Surgery on Weight Loss, Liver Function, Body Composition, Insulin Resistance, Endothelial Function and Biomarkers of Non-alcoholic Steatohepatitis (NASH) in Obese Asian Adults
Non-alcoholic fatty liver disease (NAFLD) is defined by presence of hepatic steatosis (fat accumulation in liver cells), either by imaging or by biopsy and absence of causes for secondary hepatic fat accumulation such as…
- Conditions
- Non-alcoholic Fatty Liver Disease (NAFLD), Weight Loss, Non-alcoholic Steatohepatitis (NASH)
- Trial name
- CGH-LiNASH (NCT02654665)
- Testing
- Lifestyle modification, Liraglutide
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Healthy Adult Volunteer
The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road
Journeying along the historic Silk Road exposes travelers to dramatic dietary shifts, unfamiliar microbial environments, and the physical stresses of long-distance travel-all known to disrupt gut health and cause gastrointestinal…
- Trial name
- NCT07182500
- Testing
- Probiotic
- Where
- 2 sites in China, Malaysia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Health Behavior
A Co-creational Intervention to Engage Preschoolers in Healthy Movement Behaviors
Previous research focusing on preschoolers' healthy behaviors looked at developing interventions for separate behaviors, such as physical activity and sedentary behavior.
- Trial name
- NCT06073236
- Testing
- The healthy day-project
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Ghent
Heart Arrest
Comparison of Cerebral SctO2 Between 36℃ and 33℃ of TTM After Cardiac Arrest
The investigators hypothesize that 1. if decrease in SctO2 level is caused by the degree of hypothermia, SctO2 level in the 33-TH may be lower than that in the 36-TH group. 2.
- Trial name
- NCT02889744
- Testing
- Arctic Sun
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Hospital
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A)
This phase II MATCH treatment trial investigates the good and bad effects of binimetinib in patients whose cancer has a genetic change called NRAS mutation.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Refractory Lymphoma
- Trial name
- NCT04439344
- Testing
- Binimetinib
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Gestational Weight Gain, Postpartum Weight Retention
eMOMS of Rochester
The project aims to develop, implement and evaluate electronically-mediated behavioral intervention programs for pregnant and postpartum women in order to prevent excessive weight gain during pregnancy and postpartum weight…
- Trial name
- eMOMS (NCT01331564)
- Testing
- electronic intervention during pregnancy and postpartum, electronic intervention during pregnancy, Control
- Where
- United States
- Volunteers
- 1,641 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Altered Passive Eruption of Teeth
Gummy Smile and Altered Passive Eruption Prevalence
This observational epidemiological study aims to assess the prevalence of gummy smile and altered passive eruption in a young adult population, with a focus on the second sextant.
- Trial name
- NCT07548398
- Testing
- Clinical assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Psychosis, Metabolic Syndrome
Evaluating the Effects of Adjunctive Aripiprazole on Weight and Metabolic Outcomes in Females
Patients with psychiatric disorders, including depression, anxiety, and schizophrenia, often require antipsychotic medications for symptom management.
- Conditions
- Psychosis, Metabolic Syndrome, Weight Gain
- Trial name
- NCT06590298
- Testing
- Adjunctive Aripiprazole for improving Weight and Metabolic Outcomes in Females
- Volunteers
- 600 people
- Sponsor
- Universiti Putra Malaysia
Body Image, Eating, Healthy
The Effects of Weight Science and Nutrition Education on Weight Control Beliefs and Disordered Eating.
People have different beliefs about controlling their weight. Individuals who believe they should control their weight are more likely to have poor body image, low self-esteem and disordered eating.
- Trial name
- NCT05684263
- Testing
- Weight Science Educational Video, Healthy Eating Educational Video, Healthy Sleep Educational Video
- Volunteers
- 150 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Fever, Sweats, and Hot Flashes, Infection
Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia
RATIONALE: Levofloxacin may be effective in reducing fever and controlling other symptoms of neutropenia in patients who are being treated for cancer.
- Conditions
- Fever, Sweats, and Hot Flashes, Infection, Leukemia, Lymphoma
- Trial name
- NCT00020865
- Testing
- cefepime hydrochloride, levofloxacin
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Disability Physical
Adapted Table Tennis for Disabilities
In recent years, sports participation among individuals with disabilities has increased, driven by medical advancements, growing societal awareness, and improved accessibility.
- Trial name
- NCT07671807
- Testing
- Adapted table tennis training
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Bariatric Surgery Candidate, Weight Loss
Gastric Plication in Mexican Patients
Between January and December 2012, a total of 40 patients underwent GLP. The study will assess subject excess weight loss (%EWL) following the study procedure at 3, 6, 12, 36 and 60 months.
- Conditions
- Bariatric Surgery Candidate, Weight Loss, Obesity, Morbid
- Trial name
- NCT03210207
- Testing
- GASTROPLICATURE
- Volunteers
- 40 people
- Sponsor
- Instituto Mexicano del Seguro Social
Traumatic Burst Fractures of the Thoracic or Lumbar Spine., Normal Neurological Function
Thoracic And Lumbar Burst Fracture: Correlation Between Structural Changes And Clinical Outcome Of Treatment
Evaluate the correlation between the structural changes of fractures of the thoracic and lumbar spine burst type with clinical outcome of the treatment.
- Trial name
- NCT02076607
- Testing
- Arthrodesis, Brace
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Hospital Ortopedico de Passo Fundo
Sarcopenia
Efficacy of Nutritional Supplementation on Physical-activity Mediated Changes in Physical Functioning Older Adults at Risk for Mobility Disability (The VIVE2 Study)
Several trials have found that nutritional supplementation can elicit an increased rate of skeletal muscle protein synthesis following a single bout of exercise in both young and older individuals.
- Trial name
- NCT01542892
- Testing
- Exercise Intervention, Supplement Intervention
- Where
- 2 sites in United States, Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tufts University
Diet Modification
Effects of Diet Selection Based on Genetic Screening on Success to a Weight Loss Program
The purpose of this study is to determine the effects of diet type selection based on response to a Carbohydrate Intolerance Questionnaire (CIQ) and genetic screening on success to a weight loss and exercise program.
- Trial name
- Curves3 (NCT03116711)
- Testing
- Positive CIQ plus High Carbohydrate Diet, Positive CIQ plus High Protein Diet, Negative CIQ plus High Carbohydrate Diet
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
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