Clinical trials: Monocytes
Diverticulitis
Is It So Hard To Predict Complicated Diverticulitis?
Is It So Hard To Predict Complicated Diverticulitis? Objective: Acute diverticulitis (AD) is a frequent cause of abdominal pain leading to emergency department visits.
- Trial name
- NCT07322926
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Septic Shock, Calcium Sensing Receptor
Impact of Vascular Calcification and CASR Expression by Monocytes in Septic Shock
In septic shock, bacterial LPS is able to activate the CaSR of cardiomyocytes inducing their apoptosis in vitro. CaSR activation in monocytes is responsible for activation of the NLRP3 inflammasome and macropinocytosis.
- Conditions
- Septic Shock, Calcium Sensing Receptor, Calcium Phosphate Disorders, Inflammation
- Trial name
- CASRCHOC (NCT06853340)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Leukemia, Myeloid, Acute, Leukemia, Monocytic, Acute
A Study of Volasertib Plus Induction Chemotherapy for Acute Myeloid Leukemia
This is a Phase I clinical trial to determine the maximum tolerated dose (MTD) of the polo-like kinase-1 inhibitor volasertib which can be safely combined with idarubicin plus cytarabine induction chemotherapy for previously…
- Conditions
- Leukemia, Myeloid, Acute, Leukemia, Monocytic, Acute, Leukemia, Myelomonocytic, Acute, Leukemia, Erythroblastic, Acute
- Trial name
- VIAC (NCT02527174)
- Testing
- Volasertib, Idarubicin, Cytarabine
- Where
- 2 sites in Canada
- Sponsor
- University of Alberta
Leukemia, Myelodysplastic Syndromes
Chemotherapy and Bone Marrow Transplantation in Treating Patients Acute Myeloid With Leukemia or Myelodysplastic Syndrome
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00002547
- Testing
- busulfan, cyclophosphamide, cyclosporine
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a)
Cholecalciferol in Treating Patients With Acute Myeloid Leukemia Undergoing Intensive Induction Chemotherapy
This partially randomized phase II trial studies the side effects and best way to give and best dose of cholecalciferol in treating patients with acute myeloid leukemia (AML) undergoing intensive induction chemotherapy.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b), Adult Acute Myeloblastic Leukemia With Maturation (M2)
- Trial name
- NCT01521936
- Testing
- cholecalciferol, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Roswell Park Cancer Institute
Ulcerative Colitis
ADAPT Adacolumn Pediatric Trial in Ulcerative Colitis
Children aged up to 18 years with moderately active Ulcerative Colitis (PUCAI:35-64) will receive one weekly Adacolumn® apheresis treatment over 5 consecutive weeks, followed by up to 3 optional Adacolumn® apheresis treatments…
- Trial name
- NCT00781638
- Testing
- Adacolumn®
- Volunteers
- 24 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Glioblastoma, Glioma, Malignant
Monocyte Antigen Carrier Cells for Newly Diagnosed GBM
The primary purpose of this study is to determine the maximum tolerated dose (MTD) of MT-201-GBM (pp65CMV antigen monocytes) that will be administered to patients newly diagnosed with a type of brain tumor called glioblastoma…
- Trial name
- DEMAND (NCT04741984)
- Testing
- MT-201-GBM monocyte vaccine
- Sponsor
- Michael Gunn
Acute Monocytic Leukemia, Acute Myeloid Leukemia
Venetoclax in Combination With Cladribine and Cytarabine Alternating With Azacitidine Plus Venetoclax for the Treatment of Newly Diagnosed Monocytic AML and Active Signaling Mutated AML
This phase II trial tests how well venetoclax with cladribine and cytarabine alternating with azacitidine and venetoclax works in treating patients with newly diagnosed monocytic acute myeloid leukemia (AML) and active signaling…
- Trial name
- NCT06504459
- Testing
- Azacitidine, Biospecimen Collection, Bone Marrow Aspiration
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- OHSU Knight Cancer Institute
Leukemia
S9918 PSC 833, Daunorubicin, and Cytarabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PSC 833 may help chemotherapy drugs kill more cancer cells by making them more sensitive to the drugs.
- Trial name
- NCT00004217
- Testing
- filgrastim, sargramostim, cytarabine
- Where
- 90 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- SWOG Cancer Research Network
Atherosclerosis
Effect of Statins on Trained Immunity
In this study, the investigators will determine whether patients with elevated levels of LDL are characterized by specific epigenetic changes in circulating cells of the innate immune system, compared to control subjects with…
- Trial name
- NCT02817230
- Testing
- Statin
- Where
- 3 sites in Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxygen Uptake Efficiency
Effects of Aerobic Interval and Continuous Exercise Trainings in Patients With Chronic Heart Failure
Heart failure (HF) is a major and increasingly common cardiovascular syndrome, and is the end result of many cardiovascular disorders.
- Conditions
- Cardiac and Hemodynamic Response, Blood Flow Distribution and Oxygen Uptake Efficiency, Hemorheology Modulated by Erythrocyte, Atherothrombosis Modulated by Monocyte
- Trial name
- NCT01229670
- Testing
- exercise
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung Memorial Hospital
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With Relapsed or Refractory Hematologic Cancer
This phase I trial is studying the side effects and best dose of 17-N-allylamino-17-demethoxygeldanamycin and bortezomib in treating patients with relapsed or refractory hematologic cancer.
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00103272
- Testing
- tanespimycin, bortezomib
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- National Cancer Institute (NCI)
Vascular Access for Hemodialysis and Inflammation
Vascular Access for Hemodialysis and Inflammation
The aim of the present study was to investigate patients free of active infection and/or thrombosis to assess if the type of vascular access (AVF, AVG, TCC), could influence: 1.
- Trial name
- NCT00850707
- Where
- Italy
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sepsis
PD-1/PD-L1 Pathway Study on Septic Patients
The investigators want to identify that whether PD-1/PD-L1 pathway will change in human sepsis, and whether PD-1/PD-L1 pathway play an important role in sepsis induced immunosuppression.
- Trial name
- NCT01161745
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Thalassemia Major (TM), Thalassemia Intermedia (TI)
Beta-thalassemia and Microparticles
The results will allow us to evaluate the role of MP in the thrombo-embolic risk observed in thalassemic patients and to underline a possible difference between TM and TI.
- Conditions
- Thalassemia Major (TM), Thalassemia Intermedia (TI), Microparticles (MP)Originating From Platelets, Endothelial Cells and Monocytes
- Trial name
- NCT01284738
- Testing
- Physiopathology
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Eltrombopag Olamine in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia
The purpose of this study is to find out the highest safe dose and examine the side effects and effectiveness of eltrombopag olamine in patients with acute myeloid leukemia (AML) treated with chemotherapy that have not responded…
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT01550185
- Testing
- eltrombopag olamine, standard follow-up care
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Roswell Park Cancer Institute
Pregnancy, Infections in, Covid19
Perinatal Outcomes and Hematologic Parameters in COVID-19 Pregnancies
Complete blood count parameters are routinely evaluated cost-effective markers in diagnosis and clinical follow-up of infectious diseases.There is increasing number of studies to report the course of COVID-19 in pregnancy.
- Trial name
- NCT04515108
- Testing
- Clinical assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Leukemia
flt3L in Treating Patients With Acute Myeloid Leukemia
RATIONALE: Drugs such as flt3L may stimulate a person's immune system and help kill cancer cells. It is not yet known if flt3L is effective in treating acute myeloid leukemia.
- Trial name
- NCT00006223
- Testing
- recombinant flt3 ligand
- Where
- 47 sites in United States
- Sponsor
- Eastern Cooperative Oncology Group
Atherosclerosis
Leucine, mTOR and Athero
High protein low carbohydrate diets have become popular in recent years to help facilitate weight loss. It is controversial if these diets are associated with an increased risk of cardiovascular disease.
- Trial name
- HPL (NCT05470218)
- Testing
- Meal
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Diabetic Foot Ulcer
Autonomous Regulatory Monocytes (OPM Cells) for the Treatment of Diabetic Foot in a Single-arm Open-label Clinical Study
To reduce the risk of critical limb ischemia (CLI) in diabetic patients, repair local ulcers in the limbs of diabetic patients, and avoid the occurrence of amputation, Academician Van der Rijt has developed autoregulatory…
- Trial name
- NCT06621303
- Testing
- Diabetic foot ulcer treatment
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai East Hospital