Clinical trials: Montelukast
Asthma
Montelukast in Modulating Exacerbations of Asthma in Children
The purpose of the study is to determine if Montelukast added to other therapy, if any, will reduce the severity of asthma symptoms in children during the high incidence of respiratory viral infections that occur in children in…
- Trial name
- NCT00196547
- Testing
- Montelukast (drug)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Firestone Institute for Respiratory Health
Asthma
Ventilatory Heterogeneity in Participants With Asthma (MK-0476-513)
This study will explore the utility of magnetic resonance imaging (MRI) to assess ventilatory defects that occur due to asthma, determine the sensitivity and specificity of MRI in response to drug treatment, and whether MRI can…
- Trial name
- NCT01621386
- Testing
- Montelukast, Prednisone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hal C Charles
Allergic Rhinitis
A Study to Evaluate the Safety of Combination Montelukast/Loratadine in Mexican Participants With Allergic Rhinitis (MK-0476A-484)
The purpose of this study is to assess the safety and tolerability of montelukast 10 mg/loratadine 10 mg versus placebo in Mexican participants with allergic rhinitis.
- Trial name
- NCT01673620
- Testing
- Montelukast 10 mg/loratadine 10 mg
- Volunteers
- 69 people
- Sponsor
- Organon and Co
Asthma
The Singulair® add-on Study Effectiveness of Adding Montelukast to Inhaled Corticosteroids in Adult Subjects With Uncontrolled Asthma (0476-384)
The purpose of this study is to evaluate the effectiveness of adding Montelukast Sodium (singulair®) 10 mg per day to inhaled corticosteroids in adult subjects with uncontrolled asthma.
- Trial name
- SAS (NCT00755794)
- Testing
- montelukast sodium
- Volunteers
- 800 people
- Sponsor
- Organon and Co
Coughing
Fractional Concentration of Exhaled NO(FENO) to Direct Montelukast Treatment of Sub-acute Cough
Cough is a common symptom of respiratory medicine clinic patients, which has complex etiology and wide-ranging. Cough is usually divided into three categories by time: acute cough, subacute cough and chronic cough.
- Trial name
- NCT02303600
- Testing
- Montelukast
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Chao Yang Hospital
Alzheimer Disease
Montelukast Therapy on Alzheimer's Disease
This is a one-year, double-blind placebo-controlled randomized clinical trial that compares montelukast to placebo in individuals with mild cognitive impairment (MCI) and early Alzheimer's disease (AD) dementia.
- Trial name
- NCT03991988
- Testing
- Montelukast
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Emory University
Asthma
Comparative Effects of Fish Oil Supplementation and a Montelukast on EIB and Airway Inflammation in Asthma
Combining fish oil supplementation and Montelukast [a commonly used cyst LT1 receptor antagonist to treat exercise-induced bronchoconstriction (EIB)] will provide a greater antiinflammatory effect against developing EIB that…
- Trial name
- NCT00676468
- Testing
- Active Montelukast + Active Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
Rhinitis, Allergic, Seasonal
Effects of Loratadine/Montelukast vs Pseudoephedrine and Placebo in Patients With Seasonal Allergic Rhinitis (Study P04095) (COMPLETED)
This is a Phase 3, randomized, parallel-group, multicenter, double-dummy, double-blind study with a screening period. Subjects will receive one of the following three treatment groups for 15 days: loratadine 10 mg/montelukast 10…
- Trial name
- NCT00319995
- Testing
- loratadine; montelukast
- Volunteers
- 1,095 people
- Sponsor
- Organon and Co
Ovarian Cancer, Fallopian Tube Cancer
Standard Infusion Carboplatin Versus Prophylactic Extended Infusion Carboplatin in Patients With Patients With Recurrent, Ovary, Fallopian Tube, and Primary Peritoneal Cancer
Patients who have this kind of cancer are often treated with several drugs. Carboplatin is one that seems to work for many treatment cycles. Even though it may work against the cancer, the patient can become allergic to it.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT01248962
- Testing
- carboplatin
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Asthma
Study of the Effect of Mometasone Furoate/Formoterol (MF/F), Montelukast and Beclomethasone Dipropionate (BDP) on Plasma Cortisol Levels of Children 5-11 Years Old With Persistent Asthma (P05574)
The purpose of this study is to assess the effect of one of five possible study medications used in the treatment of asthma on blood plasma cortisol levels in children aged 5-11 years with persistent asthma.
- Trial name
- NCT01615874
- Testing
- MF/F Metered Dose Inhaler (MDI) 25/5 mcg, MF/F MDI 50/5 mcg, MF/F MDI 100/5 mcg
- Sponsor
- Organon and Co
Asthma, Exercise-induced
Exercise Induced Bronchoconstriction (0476-359)
Exercise-induced bronchoconstriction (EIB) is a condition where airways tighten when you exercise and may cause coughing, wheezing, or shortness of breath.
- Trial name
- NCT00664937
- Testing
- montelukast sodium
- Volunteers
- 24 people
- Sponsor
- Organon and Co
Erythema Nodosum Leprosum, Leprosy
Montelukast in ENL Reaction
Objective of the trial is to assess the safety and efficacy of Montelukast in treatment of Erythema Nodosum leprosum (ENL) reaction in multibacillary leprosy patients either in combination with prednisolone or alone.
- Trial name
- NCT00406861
- Testing
- montelukast in treatment of ENL reaction
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- The Leprosy Mission Bangladesh
Asthma
MK0524 Asthma POC Study (0524-008)(COMPLETED)
The purpose of the study is to demonstrate the benefit of MK0524 compared to placebo in patients with chronic asthma.
- Trial name
- NCT00783601
- Testing
- Comparator: MK0524 + montelukast
- Volunteers
- 130 people
- Sponsor
- Merck Sharp & Dohme LLC
Asthma
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite
The purpose of this study is to examine wether the combination of Ramatroban/Montelukast is as effective as Montelukast alone in patients with mild to moderate atopic asthma (GINA I and II) sensitive to house dust mite.
- Trial name
- NCT00311051
- Testing
- ramatroban, montelukast
- Where
- Germany
- Sponsor
- Research Center Borstel
Asthma
Effect of Montelukast on the Expression and Variation of TGF-β for Children With Mild Persistent Asthma
The Objective of our research is to observe the effect of cysteinyl leukotriene receptor antagonist on the expression and variation of TGF-β1 levels and mRNA expression in children with mild persistent asthma in their plasma and…
- Trial name
- NCT00536705
- Testing
- montelukast
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Asthma
Safety and Efficacy Study of Adding GSK2190915 to Low Dose Inhaled Corticosteroid Treatment for Asthma Subjects > or = 12 Years of Age
The primary objective of this study is to evaluate the efficacy and safety of adding GSK2190915 100mg, GSK2190915 300mg or placebo tablets administered once daily to fluticasone propionate 100mcg inhalation administered twice…
- Trial name
- NCT01156792
- Testing
- FP 100, GSK2190915 100, GSK2190915 300
- Where
- 32 sites in United States
- Volunteers
- 162 people
- Sponsor
- GlaxoSmithKline
Asthma
Dose Ranging Study Evaluating the Efficacy and Safety of GSK2190915 Administered Once Daily
To evaluate the efficacy, dose response and safety of four doses of GSK2190915 in tablet form (10mg, 30mg, 100mg and 300mg) administered once daily, over 8 weeks compared with placebo in adolescent and adult subjects (12 years of…
- Trial name
- NCT01147744
- Testing
- Fluticasone Propionate 100mcg via ACCUHALER/DISKUS, GSK2190915 100mg, GSK2190915 10mg
- Where
- 84 sites in United States, Bulgaria and 4 more
- Volunteers
- 700 people
- Sponsor
- GlaxoSmithKline
Asthma
The Population Pharmacokinetics of Montelukast in Infants and Children
The investigators' aim was to evaluate the population pharmacokinetics of montelukast in infants and children and define the appropriate dose in order to optimize Montelukast treatment in this vulnerable population.
- Trial name
- NCT03238560
- Testing
- Montelukast Chewable Tablet
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong University
Asthma
Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics
The purpose of this study is to determine whether patients with asthma who carry a genotype associated with adverse outcomes with long-acting beta-2 agonists like salmeterol show greater benefit from the use of an asthma drug…
- Trial name
- NCT00655616
- Testing
- Salmeterol, Montelukast
- Where
- United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Dundee
Rheumatoid Arthritis
Montelukast Use in Rheumatoid Arthritis
Montelukast is widely used in patients with asthma. Several preclinical data suggest that it could be repositioned as novel strategy for managing rheumatic patients by decreasing inflammatory mediators.
- Trial name
- NCT05447520
- Testing
- Montelukast, Conventional DMARDs
- Where
- Egypt
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Noha Mansour