Clinical trials: Mood Lability
Mood Disorders
Effectiveness of Divalproex Sodium (Depakote) in Treating Children With Temper Outbursts and Severe Mood Swings
The purpose of this study is to determine the effectiveness of divalproex sodium (Depakote) versus placebo in treating children with temper outbursts and severe mood disorders.
- Trial name
- NCT00217932
- Testing
- Divalproex Sodium (Depakote)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Bipolar Disorder
N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder
We propose to conduct a double-blind placebo-controlled trial with a widely available and prototypical non-steroidal anti-inflammatory agent, aspirin, and an antioxidant agent, NAC, involving symptomatic Bipolar Disorder type I…
- Trial name
- SMRI-Bipolar (NCT01797575)
- Testing
- Aspirin, N-acetyl-cysteine (NAC), Sugar Pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The University of Texas Health Science Center, Houston
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Psychological Distress, Self-Assessment
Examining the Efficacy of Acceptance and Commitment Therapy (ACT) Microinterventions for Distressed First-Generation College Students
This research study aims to evaluate the feasibility, safety, and effectiveness of a micro-randomized acceptance and commitment therapy-based (ACT-based) intervention that is delivered to distressed first-generation college…
- Conditions
- Psychological Distress, Self-Assessment, Mood Change
- Trial name
- CompACT (NCT04081662)
- Testing
- compACT Intervention
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Emotional Instability, Borderline Personality
Exploring a New Measure of Emotion Regulation
Background: Emotion regulation has been established as an important concept in mental health research across a range of different diagnoses.
- Trial name
- EMER (NCT04779619)
- Testing
- Online self-report questionnaire completion
- Where
- United Kingdom
- Volunteers
- 903 people, healthy volunteers welcome
- Sponsor
- Sussex Partnership NHS Foundation Trust
Depression, Multiple Sclerosis
The Efficacy and Safety of Escitalopram for Depression in Multiple Sclerosis
Emotionally labile, depressed participants with multiple sclerosis treated with escitalopram will have a greater reduction in emotional lability scores and in their psychological distress scores than those who are randomized to…
- Trial name
- NCT00151294
- Testing
- escitalopram oxalate antidepressant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Premenstrual Dysphoric Disorder
Intranasal PH80 Spray for Acute Management of the Symptoms of Premenstrual Dysphoric Disorder
The objective of this study is to evaluate the effectiveness and safety in double-blind, randomized, placebo-controlled clinical trials of self administered PH80 intranasal spray for the acute management of cycle related symptoms…
- Trial name
- PH80-PMD (NCT01217775)
- Testing
- PH80
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Pherin Pharmaceuticals, Inc.
Traumatic Brain Injury (TBI), Alcoholism
Valproate for Mood Swings and Alcohol Use Following Head Injury
Successful treatment of traumatic brain injury (TBI)-induced mood lability may reduce or eliminate drinking behaviors in persons with alcohol abuse/dependence (AA/D) and affective lability following TBI.
- Trial name
- NCT01760785
- Testing
- divalproex sodium
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Women's Health
Evaluating the Effect of a Supplement on Symptoms of Hormonal Imbalance.
This is a virtual single-group trial lasting 12 weeks to evaluate the effects of Perelel Health's hormonal balance support on symptoms of hormonal imbalance and overall menstrual health.
- Trial name
- NCT06535698
- Testing
- Perelel Health Hormonal Balance Support
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Perelel Inc.
Depression
Behavioral Study of Effects of Low-Level Light Therapy on Mood and Reaction Time
The goal of this project is to use low-level light therapy (LLLT) to enhance neural metabolism in the prefrontal cortex of humans, and measure the effects of LLLT on attentional bias change following a single session of attention…
- Trial name
- NCT02390076
- Testing
- Left Low Level Light Therapy, Attention bias modification, Right Low Level Light Therapy
- Volunteers
- 51 people
- Sponsor
- Seth Disner
Alzheimer's Disease
Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease
Alzheimer's disease is a medical illness that damages the brain and causes problems with memory, mood and behavior. A substance called acetylcholine (ACh), which is naturally produced in the body, plays an important role in the…
- Trial name
- NCT00104442
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Novartis
PMS, Menstrual Cramp
A Randomized Placebo-Controlled Study to Evaluate the Effects of a Gummy and Capsule Supplement on Symptoms of Premenstrual Syndrome
This virtual, randomized, placebo-controlled clinical trial evaluates the effectiveness of a PMS capsule and PMS gummy in alleviating premenstrual syndrome symptoms over 12 weeks.
- Conditions
- PMS, Menstrual Cramp, Mood Change
- Trial name
- NCT06763809
- Testing
- PMS Capsule, PMS Gummy
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Semaine Health
Schizophrenia, Bipolar Disorder
Skills for Wellness
Severe mental illness such as schizophrenia and mood disorders typically develops at a young age and can cause life-long disability. Currently available treatments cannot cure severe mental illness.
- Conditions
- Schizophrenia, Bipolar Disorder, Major Depression
- Trial name
- SWELL (NCT01980147)
- Testing
- maCBT
- Where
- 2 sites in Canada
- Volunteers
- 360 people
- Sponsor
- Nova Scotia Health Authority
Non-Muscle Invasive Bladder Cancer
Mood Alterations in the Patients With Non-Muscle Invasive Bladder Cancer Treated With BCG
The purpose of this study is to evaluate mood changes in patients with Non-Muscle Invasive Bladder Cancer who are receiving intravesical Bacillus Calmete-Guerin (BCG).
- Trial name
- NCT05672615
- Testing
- Questionnaires, Daily Mood Diaries, Urine Specimen Collection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Menopausal Syndrome
The Effect of Internet- and Mobile-based Group Treatment in Menopausal Women
Background: Menopause syndrome generally occurs with and is related to psychological problems. However, Internet- and mobile-based group treatment (imGT) may improve women's physiological and psychological conditions.
- Trial name
- IMGTMP (NCT03948269)
- Testing
- group behavioral cognitive therapy
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Exergame, Active Video Games (AVG)
Affective and Physiological Outcomes of Virtual and Mixed Reality Workplace Exergames
The aim of this study was to compare the acute effects of virtual reality (VR) and mixed reality (MR) based exergame practices on physical and psychological health indicators during micro-breaks among university administrative…
- Conditions
- Exergame, Active Video Games (AVG), Virtual Reality, Mood Changes
- Trial name
- NCT06830772
- Testing
- Experimental, Active comparator
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Emotional Instability
Effectiveness Study of a Dialectical Behavioral Treatment for Adolescents With Emotional Instability and Their Families
Emotional instability disorder (IE) is appreciable since adolescence, and crises (suicidal ideation, self-harm, impulsive acts and brief psychotic episodes) carry a high use of health resources, coupled with the suffering of…
- Trial name
- NCT02991586
- Testing
- Dialectical Behaviour Therapy
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Shift Work Type Circadian Rhythm Sleep Disorder, Chronobiology Disorders
Effects of Shift Work on Nurse Staff Health
Shift work deeply impacts on temporal organization leading to a circadian desynchronization, which translates into a worsening of the sleep quality and work ability during waking hours.
- Conditions
- Shift Work Type Circadian Rhythm Sleep Disorder, Chronobiology Disorders, Mood Swing, Physical Activity
- Trial name
- Turnisti (NCT03453398)
- Testing
- Shifts working hours with different schedules
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio