Clinical trials: Morbidly Obese Patients
Morbid Obesity, Postoperative Pain
Patients-Controlled Epidural Analgesia After Gastric Bypass for Morbid Obesity Using Morphine-Levobupivacaine Regimens
Adequate postoperative analgesia can facilitate recovery following gastric bypass surgery for morbid obesity. The efficacy and safety of intravenous patient - controlled analgesia has been studied, but up to date no data are…
- Conditions
- Morbid Obesity, Postoperative Pain, Postoperative Bowel Function, Postoperative Ambulation
- Trial name
- NCT01249872
- Testing
- GROUP A : 0 mg MORPHINE-0.1% LEVOBUPIVACAINE, GROUP B : 1 mg MORPHINE- 0.1% LEVOBUPIVACAINE, GROUP C : 2 mg MORPHINE-0.1% LEVOBUPIVACAINE
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- University of Patras
Obesity Difficult Airway Airway Management
Videolaryngoscopes in the Morbidly Obese
This study will evaluate four videolaryngoscopes used for intubation of extremely obese (class 3 obesity) patients scheduled for bariatric surgery.
- Trial name
- NCT07787468
- Testing
- Airway management
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Uniwersytet Radomski im. Kazimierza Pułaskiego
Morbid Obesity
Correlation of Neck Circumference With Difficult Mask Ventilation and Difficult Laryngoscopy in Morbidly Obese Patients
The aim of this study is to determine the correlation of neck circumference with difficult mask ventilation and laryngoscopy in morbidly obese patients.
- Trial name
- NCT02589015
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University
ARDS, Human, Obesity, Morbid
Transpulmonary Pressure - Guided Mechanical Ventilation in Morbidly Obese ARDS Patients: a Feasibility Study.
The goal of this clinical trial is to test a personalized intervention aiming to optimize the mechanical ventilator settings in morbidly obese patients suffering from moderate to severe Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- TGV-MOA (NCT06119516)
- Testing
- Esophageal pressure-guided strategy,
- Where
- 5 sites in France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity
Effects of Different PEEP Levels on Work of Breathing in Morbidly Obese Patients Prior to and After Extubation
The main purpose of this study is to define at the bedside the "Titrated-PEEP" level for obese patients that increases the likelihood of extubation and ventilator liberation.
- Trial name
- NCT02492113
- Testing
- Positive end-expiratory pressure (PEEP), ZEEP
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Morbid Obesity, Non Alcoholic Steatohepatitis
Non Invasive Measurements of Fibrosis, Inflammation and Steatohepatitis in Morbidly Obese Patients
Abstract: Fatty liver most frequently corresponds to a fat overload of the liver. It is usually classified as alcoholic steatosis or non-alcoholic steatosis.
- Trial name
- FIRM (NCT01695083)
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Morbid Obesity, Pregnancy
Induction of Labor in Morbidly Obese Patients
The goal of this randomized control trial is to compare different doses of Misoprostol (25 mcg vs 50 mcg) in induction of labor (IOL) in morbidly obese patients with BMI >40.
- Trial name
- NCT06199154
- Testing
- Misoprostol
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Maryland, Baltimore
Obesity, Anaesthesia
CPAP/PSV Preoxygenation in Obese Patients
The purpose of this study is to determine whether continuouse positive airway pressure (CPAP), during induction of anaesthesia in morbidly obese patients, result in higher levels of oxygen in the blood.
- Trial name
- NCT01780571
- Testing
- CPAP 5 cm H2O + PSV 5 cm H2O
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity
Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers
OCAPUSH (EudraCT 2014-002313-33) is a double-blind placebo-controlled parallel-arms study of the effects of obeticholic acid on farnesoid X receptor expression in jejunum and on gut microbiota in morbidly obese patients and…
- Trial name
- OCAPUSH (NCT02532335)
- Testing
- Obeticholic acid
- Where
- 2 sites in Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Morbid Obesity, Thromboembolism
Prophylaxis of Venous Thromboembolism After Bariatric Surgery
This study is a prospective evaluation of the relationship between lean body weight and anti-Xa activity and 5700 International Units (IU) nadroparin 4 hours after subcutaneous administration in morbidly obese patients after…
- Conditions
- Morbid Obesity, Thromboembolism, Bypass Complications
- Trial name
- NCT02295150
- Testing
- Nadroparin
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Rijnstate Hospital
Morbid Obesity
Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass
Prospective randomized clinical trial aiming to compare laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) with primary outcome on excess weight loss, and secondary outcomes on nutritional status, glycolipid…
- Trial name
- NCT02475590
- Testing
- Laparoscopic sleeve gastrectomy, Laparoscopic Roux-en-Y gastric bypass
- Where
- France
- Volunteers
- 100 people
- Sponsor
- IHU Strasbourg
Type 2 Diabetes Mellitus
The Surgical Treatment of Type 2 Diabetes Mellitus in Non-Morbidly Obese Patients: A Community Hospital Study
Type 2 diabetes mellitus is a chronic disease with severe long-term health consequences. In patients with type 2 diabetes mellitus who are also morbidly obese, an abundance of clinical evidence exists showing that significant…
- Trial name
- NCT01323114
- Testing
- Laparoscopic duodenal exclusion, Conventional Medical Treatment
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- McKenzie Health System
Bariatric Surgery Candidate, Dysbiosis
The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric Surgery
This study explores the effects of probiotic administration on the outcomes of surgical treatment, and also on the state of the intestinal microbiota and the intestinal barrier.
- Trial name
- NCT05407090
- Testing
- probiotic supplementation
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Pain, Postoperative
Comparison of QLB Block and TAP Block in Morbid Obese Patients
Quadratus lumborum block (QLB) and Transversus abdominis plane (TAP) blocks are regional anesthesia techniques that are frequently used to reduce postoperative pain and are an important part of the current analgesic regimen for…
- Trial name
- NCT05820620
- Testing
- TAP block, QLB block, Control Group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Biruni University
Obesity, Morbid, Liver Fibrosis
Performances Evaluation of New FibroScan Probes Dedicated to Morbidly Obese Patients
Non-Alcoholic Fatty Liver is a common clinical and histological condition associated with metabolic syndrome in patients with and without excess body weight.
- Trial name
- NCT03872024
- Testing
- For the first 60 patients: 3 XXL probe prototypes of the FibroScan 630 Research Model, From patient 61 to patient 120: 1 XXL probe prototype of the FibroScan 630 Research Model
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Echosens
Obesity, Morbidly Obese
Novel SaCoVLM™ Video Laryngeal Mask Airway as an Intubation Conduit in Morbidly Obese Bariatric Surgery
Background: The SaCoVLM™ video laryngeal mask is a novel video-assisted device that integrates the functions of both a dual-channel laryngeal mask airway (LMA) and an intubating laryngeal mask airway (ILMA).
- Trial name
- NCT07573813
- Testing
- SaCoVLM™ in Difficult Airways
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Yongtao Sun
Sleep Apnea, Gastroesophageal Reflux Disease
Effect of Continuous Positive Airway Pressure (CPAP) on Lower Esophageal Sphincter Pressure in Morbidly Obese Patients
This trial is enrolling patients who are already being seen at OHSU weight loss clinic or have been referred for clinical reasons by their physician to the OHSU weight loss clinic and are going to have a esophageal manometry that…
- Trial name
- NCT01099735
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oregon Health and Science University
Morbid Obesity, Hiatal Hernia
Laparoscopic Sleeve Gastrectomy With or Without Hiatal Hernia Repair in Morbidly Obese Patients
Background: Obesity and hiatal hernia are both risk factors of gastroesophageal reflux disease (GERD), and the incidence of hiatal hernia is much higher in morbidly obese patients.
- Conditions
- Morbid Obesity, Hiatal Hernia, Gastroesophageal Reflux Disease, Sleeve Gastrectomy
- Trial name
- NCT03776669
- Testing
- Laparoscopic sleeve gastrectomy + Hiatal hernia repair, Laparoscopic sleeve gastrectomy alone
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Obesity, Morbid
Pharmacokinetics of Propofol in Morbidly Obese Patients
The objectives of this study are To determine PK of propofol in bariatric patients To identify the physiological variables that induce propofol PK changes in bariatric patients, when compared to a normal-weight population.
- Trial name
- NCT01536002
- Testing
- Propofol
- Where
- Norway
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Spinal Anesthesia, Ultrasound Assistance
Spinal Anesthesia Using Ultrasound Assistance Versus Conventional Palpation in Morbidly Obese Patients
The aim of this study is to compare the paramedian approach for spinal anesthesia using ultrasound assistance (USAS) versus conventional palpation in morbidly obese patients undergoing elective surgeries.
- Conditions
- Spinal Anesthesia, Ultrasound Assistance, Obesity, Morbid
- Trial name
- NCT05240846
- Testing
- Paramedian conventional palpation group, Ultrasound assistance paramedian spinal group
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Kafrelsheikh University