Clinical trials: Motility Disorder
Temporomandibular Disorder, Temporomandibular Joint Disorders
Effect of Exercises on Convergence Insufficiency in Individuals With Temporomandibular Disorders
Temporomandibular Disorder is a disorder that involves the muscles of mastication, the temporomandibular joint (TMJ), and associated structures.
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome, Convergence Insufficiency
- Trial name
- NCT05761106
- Testing
- Oculomotor Therapy, Therapy for Temporomandibular Disorder
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Nove de Julho
Strabismus, Comitant
Single Minimal Conjunctival Incision for Strabismus
The purpose of this investigation is to study the feasibility and inflammatory response of surgery for rectus muscles using a small single bulbar conjunctival incision posterior and parallel to the muscle insertion.
- Trial name
- NCT05987878
- Testing
- single minimal conjunctival incision
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Universidad Autonoma de Madrid
Insomnia, GERD
Sleep Disorders and Gastroesophageal Reflux Disease (GERD)
This study will investigate Gastroesophageal Reflux Disease (GERD)as a cause of sleep disturbance. Patients with GERD may experience all or some of the following symptoms: stomach acid or partially digested food re-entering the…
- Trial name
- NCT00287391
- Testing
- Rabeprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Barrett's Esophagus
Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett's Esophagus Compared With Standard Endoscopy
The purpose of this study was to evaluate whether a disposable nasal endoscope called "E.G. Scan II" will visualize the esophagus as well as the standard test, sedated endoscopy.
- Trial name
- NCT02066233
- Testing
- EG Scan II (transnasal endoscopy), Standard Endoscopy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux
A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD
LNF is an effective intervention in the management of patients with chronic GERD requiring maintenance therapy. LNF is cost-effective compared with long-term medical therapy.
- Trial name
- NCT00182260
- Testing
- Proton Pump Inhibitors, Laparoscopic Nissen Fundoplication
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- McMaster University
Progressive Supranuclear Palsy, Dementia With Lewy Bodies
In-Home Care for Patients With PSP and Related Disorders
Progressive Supranuclear Palsy and related disorders (PRD) are debilitating, costly, and understudied conditions. Improving access to comprehensive, specialized, in-home patient care offers the potential to minimize the downward…
- Conditions
- Progressive Supranuclear Palsy, Dementia With Lewy Bodies, Multiple System Atrophy, Corticobasal Syndrome
- Trial name
- NCT03552484
- Testing
- Home Visit Program, Usual Care/Online Survey
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Obesity
MOTIVATE Weight Loss Study
The purpose of this study is to evaluate the impact of minor variations in Incisionless Operating Platform (IOP)procedural techniques on gastric emptying, hormone levels, satiety, and weight loss in the treatment of primary…
- Trial name
- MOTIVATE (NCT01679158)
- Testing
- Using The IOP system from USGI to place suture anchors
- Where
- Spain
- Volunteers
- 18 people
- Sponsor
- USGI Medical
Constipation, Childhood Acute Lymphoblastic Leukemia
Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation
To gain a better understanding of the underlying dysmotility in constipation in children, we will use a novel minimal invasive method called 3D Transit.
- Conditions
- Constipation, Childhood Acute Lymphoblastic Leukemia, Neurofibromatosis 1, Chronic Constipation With Overflow
- Trial name
- NCT03981510
- Testing
- 3D-Transit
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Gastro-esophageal Reflux Disease
Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy
Gastro-esophageal reflux disease (GERD) is defined as the reflux of gastric content into the esophagus that causes troublesome symptoms or complications.
- Trial name
- PRIMER (NCT03596476)
- Testing
- Upper gastrointestinal (GI) endoscopy, Wireless pH monitoring, Post prandial esophageal High Resolution Impedance Manometry
- Where
- 7 sites in France
- Volunteers
- 330 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Morbid, Bariatric Surgery Candidate
Trends and Safety in Revisional Bariatric Surgery in Italy
Background: Revisional bariatric surgery (RBS) represents a further solution for patients who experience an inadequate response following initial bariatric surgery or significant weight regain following an initial satisfactory…
- Conditions
- Obesity, Morbid, Bariatric Surgery Candidate, Remission, Complication,Postoperative
- Trial name
- NCT05194943
- Testing
- revisional bariatric surgical procedures
- Where
- 11 sites in Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Anesthesia
Electrical Acupoint Stimulation on Gastric Reflux During I-gel Ventilation
This study will compare the effects of transcutaneous acupoint electrical stimulation versus no stimulation on intraoperative gastric reflux in patients undergoing general anesthesia with i-gel airway device ventilation.
- Trial name
- ASGARD-igel (NCT07338448)
- Testing
- transcutaneous electrical acupoint stimulation, electrodes attachment
- Volunteers
- 116 people
- Sponsor
- Air Force Military Medical University, China
GERD, Morbid Obesity
Management of Reflux After Sleeve Using Stretta
Gastroesophageal reflux disease (GERD) is a frequently seen entity after sleeve gastrectomy. Management of GERD after sleeve is difficult given limited treatment modalities.
- Trial name
- MaRSS (NCT02637713)
- Testing
- Stretta, Radiofrequency (RF) Energy to the LES (Stretta Procedure)
- Where
- 13 sites in United States
- Volunteers
- 5 people
- Sponsor
- Montefiore Medical Center
Supranuclear Palsy, Progressive
Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder with…
- Trial name
- NCT00139373
- Testing
- donepezil
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Pharmacokinetics, Cardiodynamic ECG
A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate
This is a Phase I, single-center, double blind, placebo-controlled, parallel-group, randomized trial designed to evaluate the PK, cardiodynamic ECG effects, safety, and tolerability of single oral doses of linaprazan glurate.
- Conditions
- Pharmacokinetics, Cardiodynamic ECG, Safety, and Tolerability, GERD
- Trial name
- NCT05469854
- Testing
- Linaprazan glurate
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Non-erosive Reflux Disease
A Study to Investigate the Pharmacodynamic Effect After Four-week Omeprazole Treatment of Non-erosive Reflux Disease in a Japanese Population
The purpose of this study is to investigate the pharmacodynamic effect of omeprazole n a Japanese non-erosive reflux disease population
- Trial name
- NCT00259051
- Testing
- Omeprazole
- Where
- 13 sites in Japan
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
GERD, Barrett's Esophagus
A Feasibility Study of Confocal Microendoscopy in the Evaluation of Gastrointestinal Neoplasia -Project 1
The overall objective of this study is to obtain data to evaluate whether high-resolution imaging of the gastrointestinal mucosain vivo can assist clinicians in detecting dysplastic (precancerous) areas.
- Trial name
- NCT01384695
- Testing
- Fluorescein, Proflavine hemisulfate
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Gastroesophageal Reflux
Study to Evaluate the Pharmacokinetics and Safety of Dexlansoprazole in Pediatric Subjects With Symptomatic Gastroesophageal Reflux Disease
The purpose of this study is to assess the pharmacokinetics and safety of dexlansoprazole, once daily (QD), in pediatric subjects with symptomatic Gastroesophageal Reflux Disease.
- Trial name
- NCT01045096
- Testing
- Dexlansoprazole
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- Takeda
Esophageal Motility Disorders
Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital
to determine the prevalence and distribution of esophageal motility disorders in NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring
- Trial name
- NCT05402462
- Testing
- upper endoscopy
- Volunteers
- 90 people
- Sponsor
- Assiut University
GERD
Canadian, Multi-Centre Study of Symptom Burden and Clinical Management in Subjects With GERD
This is a cross-sectional study of symptom burden and clinical management. A subset of patients who have attended the Primary Care (PC) office with reflux symptoms during a retrospective period of 4 months (Index Visit) are…
- Trial name
- RANGE (NCT00634023)
- Where
- 15 sites in Canada
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal
Evaluation of the Efficacy and Safety of Eolo in Patients With NERD
Background: Non-erosive reflux disease (NERD) is a prevalent subtype of gastroesophageal reflux disease (GERD), often inadequately managed with proton pump inhibitors (PPIs) alone.
- Conditions
- Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal, Nutraceutical
- Trial name
- NCT07041060
- Testing
- EOLO, PPI (proton pump inhibitor), Group C: Eolo
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bologna
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