Clinical trials: Motility Disorder
Gastroesophageal Reflux
Effect of a Nickel Free Diet and Nickel Sensitization on GERD Patients.
There is little evidence on the effect of a nickel-free diet on gastroesophageal reflux disease (GERD). We hope to determine if a nickel-free diet improves GERD symptoms in patients with a nickel allergy by having patients…
- Trial name
- NCT03720756
- Testing
- Nickel-free diet
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Barrett Esophagus, Esophageal Adenocarcinoma
Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma
This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic…
- Trial name
- NCT03961945
- Testing
- Sponge Capsule
- Where
- 8 sites in United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
GERD
A Study to Investigate the Effect of Food on the PK, PD of CKD-381 in Healthy Volunteers
A study to investigate the effect of food on the Pharmacokinetics and pharmacodynamics of CKD-381 in healthy volunteers
- Trial name
- NCT04830930
- Testing
- CKD-381
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastroesophageal Reflux Disease, Chronic Cough
Cough Reflex Sensitivity and Bronchial Hyper-responsiveness
The aim of this study is to provide pilot data on the possible gastrointestinal predictors of respiratory hyper-responsiveness and how these relate to the clinical sub-types of gastroesophageal reflux disease (GERD) and visceral…
- Conditions
- Gastroesophageal Reflux Disease, Chronic Cough, Broncho-hyperreactivity
- Trial name
- NCT01777867
- Testing
- Cough Reflex Sensitivity, Methacholine Challenge
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux
Inclined Positioning and Infant Gastroesophageal Reflux
The purpose of this voluntary research study is to evaluate the extent to which infants with Gastroesophageal Reflux (GER) exhibit oxygen desaturation (low oxygen levels in their blood) and bradycardia (slow heart rate) in supine…
- Trial name
- Infant GER (NCT04542239)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Emergence Delirium, Strabismus
Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Strabismus surgery for children is a very common procedure, with a high incidence of emergence delirium in the recovery room. Pain is often implicated in delirium.
- Trial name
- NCT03778372
- Testing
- Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Heartburn
A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes
This decentralized, randomized, double-blind, placebo-controlled, two-period crossover study will evaluate whether PepZinGI® (zinc-L-carnosine) reduces food-triggered heartburn compared with placebo.
- Trial name
- NCT07379645
- Testing
- PepZinGI
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NutriScience Innovations, LLC
Aspiration, Gastroesophageal Reflux
Pepsin As A Biomarker For Aspiration
Evaluation of tracheal pepsin as a biomarker for aspiration
- Trial name
- NCT00865995
- Testing
- Tracheal Lavage
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Chronic Progressive External Ophthalmoplegia
MRI Study - Chronic Progressive External Ophthalmoplegia
The purpose of this study is to investigate the fraction of fat on a MRI scan of lower bag muscles, thighs and calves in patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO).
- Trial name
- CPEO (NCT02161848)
- Testing
- Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Colon Disease, Functional Constipation
Non-invasive Assessment of Colonic Motility
The current diagnostic process of colonic motility disorders often takes a long time and involves multiple invasive, painful and/or unnecessary diagnostic procedures.
- Conditions
- Colon Disease, Functional Constipation, Electroenterography, Slow Transit
- Trial name
- non-CoMoti (NCT04624334)
- Testing
- Elektro-Entero-Graphy procedure, EEnG Questionnaire, Gold Standard Questionnaire
- Where
- Netherlands
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Gastroesophageal Reflux
MSG and Gastrointestinal Motility
The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility ( gastric emptying).
- Trial name
- NCT01009658
- Testing
- Monosodium glutamate, Sodium chloride
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gunma University
Gastro Esophageal Reflux
A Study to Compare PK/PD Characteristics and Safety Profiles Between AD-212-A and AD-2121
Primary endpoint of this study is to evaluate the pharmacokinetic and pharmacodynamic characteristics of AD-212-A in healthy subjects.
- Trial name
- NCT06025773
- Testing
- Lansoprazole 15 mg, Lansoprazole 15mg/Calcium carbonate 600mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Stomach Ulcer, Gastroesophageal Reflux
Pharmacodynamics and Safety of CDFR0209
This is a randomized, open-label, two-way crossover study to investigate the pharmacodynamics(24 hour gastric pH) and the safety between repeated doses of CDFR0209 and Losec in Healthy Male Volunteers
- Trial name
- NCT02710994
- Testing
- CDFR0209, Losec
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Progressive Supranuclear Palsy
Test-retest Study With [18F]PI-2620 in PSP-RS and NDC
The overall goal of this protocol is to evaluate the imaging characteristics of [18F]PI-2620 using positron emission tomography (PET) in patients with progressive supranuclear palsy, Richardson's syndrome (PSP-RS)
- Trial name
- NCT05187546
- Testing
- [18F]-PI2620
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Life Molecular Imaging GmbH
Progressive Supranuclear Palsy (PSP), Healthy Participants
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
This clinical study is being conducted to learn more about two new imaging drugs, called [18F]ABBV-964i and [18F]ABBV-965i, which are designed to help doctors see changes in the brain related to a condition called Progressive…
- Trial name
- NCT07348276
- Testing
- [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Invicro
Primary Ciliary Dyskinesia, Cystic Fibrosis
Respiratory Function, Exercise Capacity and Peripheral Muscle Strength Among Patients With CF, PCD and Healthy Children
The aim of this study is to compare pulmonary function, respiratory muscle strength, exercise capacity and peripheral muscle strength of patients with CF, PCD and healthy childrens.
- Trial name
- NCT04161313
- Testing
- Measurement of functional capacity, pulmonary function test, Functional capacity
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Gastroesophageal Reflux Disease, Dyspepsia
Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease
Endoscopic Tri-Modal Imaging which combines Narrow-band Imaging(NBI), Autofluorescence Imaging (AFI) and White-light Imaging (WLI) could be used to identify the indistinct changes in the gut caused by reflux disease,either acid…
- Conditions
- Gastroesophageal Reflux Disease, Dyspepsia, Bile Reflux
- Trial name
- NCT02685150
- Testing
- Endoscopic Tri-Modal Imaging, Omeprazole, Analysis of gastric juice
- Where
- China
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Gastroesophageal Reflux Disease
A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects
A study to compare the safety, pharmacokinetics and pharmacodynamics of YPI 011 to Rabeprazole in healthy adult subjects
- Trial name
- NCT04703868
- Testing
- Rabeprazole Sodium 10mg, Rabeprazole Sodium 20mg
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Sleep Apnea, Hypertension
Tri Staple Technology Stapler Used in Gastric Bypass
The objectives of this clinical trial are to assess in a pilot setting the overall performance and safety of the Endo GIA™ Stapler with Endo GIA™ SULU with Tri-Staple™ Technology when used in a gastric bypass procedure.
- Conditions
- Sleep Apnea, Hypertension, Hyperlipidemia, Coronary Artery Disease
- Trial name
- NCT01026103
- Testing
- Tri Staple Technology stapler
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
- Conditions
- Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome
- Trial name
- NCT03059420
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital