Clinical trials: Motility Disorder
Gastroesophageal Reflux Disease (GERD)
Study to Assess Management Strategies for the Use of Esomeprazole (Nexium) in Helicobacter Pylori Infected Patients
The primary objective of this study is to investigate whether eradication treatment of Helicobacter pylori followed by therapy with esomeprazole for a total of 8 weeks extends the time to relapse in patients with gastroesophageal…
- Trial name
- NCT00574925
- Testing
- Esomeprazole
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Magnetic Resonance Imaging of Motility in Crohn's 1
Crohn's disease (CD) is becoming more common. One of the main features of this disease is weight loss and malnutrition with symptoms such as tummy aches and bloating.
- Trial name
- MIC1 (NCT02717117)
- Testing
- Soup meal
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
GERD
A Study to Monitor Intragastric pH in Patients Taking Rabeprazole vs. Patients Taking Pantoprazole
The purpose of the study is to demonstrate in patients that oral rabeprazole produces equivalent acid suppression to intravenous pantoprazole on Day 1 of drug administration.
- Trial name
- NCT00378287
- Testing
- rabeprazole sodium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Janssen-Ortho Inc., Canada
Gastroparesis
Determination of the Characteristics of Isometric Gastric Motility Measurement in Healthy Volunteers
There is a clear need for a novel method that can readily assess gastric motility in daily clinical practice. Isometric determination of the stomach motility would avoid the use of a large flaccid balloon while still being…
- Trial name
- ANTERO-AC-2 (NCT03441230)
- Testing
- Balloon characteristics
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Prof Dr Jan Tack
GERD
Understanding the Pathophysiology and Effects of Diaphragmatic Breathing in Upright Gastroesophageal Reflux
This study aims to understand why patients have predominantly upright gastroesophageal reflux disease by comparing such patients to healthy persons AND whether a behavioral intervention (diaphragmatic breathing) will impact this…
- Trial name
- NCT02972047
- Testing
- Diaphragmatic Breathing
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Minor Digestive Disorders
Prevention of the Minor Digestive Disorders by Lactobacillus Reuteri Supplementation
Aim of the study. To evaluate if L. reuteri DSM 17938 supplementation since the first days of life can reduce the onset of gaseous colic in neonates and the onset of minor digestive disorders such as regurgitation and…
- Trial name
- NCT01235884
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Italy
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- University of Bari
Vestibular Function Tests, Nystagmus Vestibular
Post- Rotatory Nystagmus Test: Normative Data for Spanish Adolescents and Adults
The vestibulo-ocular reflex is the motor response of our eyes in the opposite direction to a translational or rotational movement of our head.
- Trial name
- NCT04788134
- Testing
- Post-rotatory nystagmus test
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Quesada, Rocío Vico
Gastro Esophageal Reflux
Bitter Tastants and Reflux
Recently the relationship between intragastric pressure (IGP) and reflux events after a meal was investigated, both in gastro-esophageal reflux disease (GERD) patients and in healthy volunteers.
- Trial name
- NCT03777787
- Testing
- Denatonium Benzoate, Water
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Barretts Esophagus With Dysplasia
The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus
This study evaluates the addition of an alginate based solution to twice daily proton pump inhibitor therapy (PPI) in patients undergoing ablative therapy for dysplastic Barrett's esophagus.
- Trial name
- NCT03193216
- Testing
- Alginates
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Gastroesophageal Reflux Disease
The Effect of High PCO2 Solution on Esophageal Acid Sensation
To determine the effect of intraesophageal high PCO2 solution as compared to acidic and saline solutions on subjects' heartburn sensation using stiumlus-response functions.
- Trial name
- PC02 (NCT01128608)
- Testing
- 24-Hr Esohpageal pH Monitoring, PCO2 Acid Perfusion and 0.1N HCI Perfusion
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Southern Arizona VA Health Care System
Gastrointestinal Motility Disorder
A Phase 1, Multiple Intravenous Dose Study to Examine Safety, Tolerability, and PK of Intravenous TD-8954, a 5-HT4 Receptor Agonist, in Healthy Subjects
This is a single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics (PK) of repeated IV doses of TD-8954 in healthy adults 18 to 45 years of age and healthy…
- Trial name
- NCT01644240
- Testing
- TD-8954
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Theravance Biopharma
Pulmonary Aspiration of Gastric Contents, Adverse Effects in the Therapeutic Use of Other and Unspecified General Anaesthetics
Safety of Gastric Volume Emptying After the Intake of Maltodextrin and Glutamine
Carbohydrates (CHO)-based drinks 2h before the induction of anesthesia are recommended to decrease insulin resistance. The addition of glutamine (GLN) in these beverages may enhance the benefits of CHO alone.
- Conditions
- Pulmonary Aspiration of Gastric Contents, Adverse Effects in the Therapeutic Use of Other and Unspecified General Anaesthetics, Pulmonary Aspiration During Anaesthetic Induction
- Trial name
- NCT01798342
- Testing
- Maltodextrin, Glutamine
- Where
- Brazil
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federal University of Mato Grosso
Amblyopia, Strabismus
Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner
The purpose of this project is to compare the performance of the Pediatric Vision Scanner (PVS) with the Gold Standard Examination to determine the effectiveness of the PVS at detecting amblyopia and strabismus.
- Trial name
- NCT01726842
- Testing
- Pediatric Vision Scanner
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Gastroesophageal Reflux, Apnea
Study of Erythromycin in GER-Associated Apnea of the Newborn
To evaluate the relationship of reflux and apnea and to determine whether the administration of erythromycin improves the incidence of GER and GER-associated apnea, bradycardic and/or desaturation events in a prospective…
- Conditions
- Gastroesophageal Reflux, Apnea, Bradycardia
- Trial name
- SEGAN (NCT01825473)
- Testing
- Erythromycin, Multi-channel intra-luminal impedance (MII) pH monitoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Laryngopharyngeal Reflux
Comparison of Voice Therapy and Antireflex Therapy in LPR
This study will be a prospective, randomized, unblinded but controlled trial. Patients presenting to the Otolaryngology clinic who are diagnosed with laryngopharyngeal reflux disorder related dysphonia and meet inclusion criteria…
- Trial name
- NCT02530879
- Testing
- Omeprazole, Lansoprazole, Esomeprazole, Rantidine, Voice therapy, Combination of anti-reflux medication and voice therapy
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Temple University
Gastroesophageal Reflux Disease, Acid Reflux
Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants
A randomized, open-label study with antacid-control will be performed over 48 hours period by continuous pH impedance and bravo capsule monitoring.
- Conditions
- Gastroesophageal Reflux Disease, Acid Reflux, Obesity
- Trial name
- NCT03516188
- Testing
- Alginate-antacid group, Non antacid alginate group
- Where
- Malaysia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Abdominoplasty, Diaphragm
Gastroesophageal Reflux and Respiratory Function in Patients Undergoing Abdominoplasty
The objective of this observational study is to compare parameters of diaphragmatic mechanics, respiratory muscle function, and thoracoabdominal kinematics among women with gastroesophageal reflux disease (GERD) and a history of…
- Conditions
- Abdominoplasty, Diaphragm, Respiratory Mechanics, Gastroesophageal Reflux Disease
- Trial name
- NCT07868562
- Testing
- Assessment of anthropometric and sociodemographic data and clinical history, Assessment of Symptoms, Quality of Life, and Physical Activity, Spirometric assessment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Heartburn
Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn
Remote un-controlled trial to evaluate the tolerability of MHS-1031 and separately the tolerability of the formulated placebo in subjects with heartburn.
- Trial name
- NCT05363618
- Testing
- Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml)
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Sciences
Valvular Heart Disease Stenosis and Regurgitation, Valvular Heart Disease
Screening of Valvular Heart Disease Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 1000 patients over 18 years old in the training sample and 200 patients over 18 years old in the test…
- Trial name
- NCT07099417
- Testing
- No intervention (observational study)
- Where
- Russia
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
ADHD, Convergence Insufficiency
Study of Eyes and Attention Deficit (SEAD)
Attention-Deficit Hyperactivity Disorder (ADHD) is considered to be one of the most prevalent chronic health conditions in children. It affects between 4% and 12% of young children.
- Conditions
- ADHD, Convergence Insufficiency, Accommodative Insufficiency
- Trial name
- NCT00472511
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University