Clinical trials: Motility Disorder
Refractive Error, Visual Impairment
The Baltimore Reading and Eye Disease Study
The Baltimore Reading and Eye Disease Study (BREDS) is a two year study to determine the prevalence of vision problems in an early school age population with reading difficulty.
- Conditions
- Refractive Error, Visual Impairment, Convergence Insufficiency, Reading Disabilities
- Trial name
- BREDS (NCT02607384)
- Testing
- Eyeglass wearing, Orthoptic exercises, Specialist referral
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bone Turnover Rate Disorder, Calcium Metabolism Disorders
Effects of Lansoprazole on Bone Turnover Markers
Use of proton pump inhibitors (PPI) has increased in recent years. There are concerns that PPIs have possible negative effects on bone metabolism.
- Trial name
- NCT04814316
- Testing
- Blood and urine specimens
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Bradycardia, Strabismus
The Alaska Oculocardiac Reflex Study
Observation study monitoring vital signs and anesthetic variables particularly heart rate during prospective, ocular manipulation and specifically uniform tension on extra ocular muscles during strabismus surgery.
- Trial name
- AK-OCR (NCT04353960)
- Testing
- electrocardiograph
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Alaska Blind Child Discovery
Functional Gastrointestinal Disorders, Infant Conditions
Prevalence of FGIDs and Probiotics Study
This is a study to evaluate the prevalence of FGIDs in infants using the Thai version of Rome IV diagnostic questionnaire for functional gastrointestinal disorders in infants and evaluate the efficacy of Limosilactobacillus…
- Trial name
- PROOF (NCT06309199)
- Testing
- Biogaia
- Where
- Thailand
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Gastroesophageal Reflux Disease
Narrow-band Imaging, Autofluorescence Imaging and Gastroesophageal Reflux Disease
Aim of this study is to compare the efficacy of narrow band imaging (NBI) and autofluorescence imaging (AFI) to distinguish subtle mucosal change related to acid reflux that is not visible in standard white light imaging (WLI)…
- Trial name
- NCT01504971
- Testing
- symptom questionaire, pH monitoring, Tri-modal imaging endoscopy
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Emergence Delirium, Strabismus
Methadone for Emergence Delirium in Children Undergoing Outpatient Strabismus Surgery
Strabismus surgery for children is a very common procedure, with a high incidence of emergence delirium in the recovery room. Pain is often implicated in delirium.
- Trial name
- NCT03778372
- Testing
- Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Convergence Insufficiency
Screening for Convergence Insufficiency in School-age Children
The purpose of this study was to assess the ability of common tests of eye alignment, convergence, and accommodation to identify children with convergence insufficiency in a school screening setting.
- Trial name
- NCT00472407
- Where
- United States
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Glaucoma, Retinal Disease
The EASE Study - Human Factor and Usability Testing of a Binocular OCT System
Ophthalmology is among the most technology driven of all medical specialties, with advanced medical imaging devices - and specialised computer software - increasingly adopted for routine clinical use.
- Conditions
- Glaucoma, Retinal Disease, Strabismus, Healthy Volunteers
- Trial name
- EASE (NCT02822612)
- Testing
- Binocular OCT prototype
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University College, London
Amblyopia, Strabismus
Improving Quality Vision Outcomes in Managed Care Setting While Reducing Cost by Use of Accurate, Automated Screening
Amblyopia ("lazy eye") and strabismus (misaligned eyes) are medical eye conditions that combine as the leading causes of preventable vision loss in children.
- Trial name
- NCT02536963
- Testing
- Pediatric Vision Scanning device, Reference examination
- Where
- United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Rebiscan, Inc.
Gastroesophageal Reflux
Which Supraesophageal Reflux Symptoms Reliably Respond to Proton-Pump-Inhibitor (PPI) Therapy
The investigators hypothesize that persons with the particular cluster of symptoms that are due to supraesophageal reflux (SER) will have complete resolution of those symptoms with adequate acid suppression when a PPI is…
- Trial name
- NCT00170001
- Testing
- Nexium, Sugar Pill
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
GERD
A Study to Compare PK and Safety of CKD-381 and D026 in Healthy Male Subjects
A Study to compare pharmacokinetics and safety of CKD-381 and D026 in healthy male subjects
- Trial name
- NCT03444402
- Testing
- CKD-381(formulation I), CKD-381(formulation II), D026(Nexium 40mg)
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT01048840
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heartburn
Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn
Remote un-controlled trial to evaluate the tolerability of MHS-1031 and separately the tolerability of the formulated placebo in subjects with heartburn.
- Trial name
- NCT05363618
- Testing
- Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml)
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Sciences
Oesophageal Reflux
Determination of the Left Paratrachéal Force Required to Occlude the Esophageal Entrance
Determine the force required to occlude the esophagus with a left paratracheal pressure
- Trial name
- NCT05214079
- Testing
- Left paratracheal pressure
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Liege
Barrett's Esophagus, Gastroesophageal Reflux Disease
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry
The purpose of this study is to determine or evaluate the risk factors such as smoking, family history etc. that cause esophageal cancer and to determine the genetic changes that lead to esophageal cancer.
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease, Esophageal Adenocarcinoma
- Trial name
- NCT00574327
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Morbid Obesity, GERD
GERD After Sleeve Gastrectomy
The main adverse effect is gastroesophageal reflux disease (GERD), with concern on the development of Barrett's esophagus and esophageal adenocarcinoma in the long term. However, the relationship between SG and GERD is complex.
- Trial name
- NCT05178446
- Where
- Italy
- Volunteers
- 14,362 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Asthenopia, Contact Lenses
Connecting Contact Lenses and Digital Technology
This study seeks to address whether or not different types of daily disposable soft contact lenses may be a beneficial option for patients complaining of eye strain and visual discomfort while using digital devices.
- Conditions
- Asthenopia, Contact Lenses, Ocular Accommodation, Convergence, Excess
- Trial name
- NCT02921087
- Testing
- Test Daily Disposable Soft Contact Lenses, Control Daily Disposable Soft Contact Lenses
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- State University of New York College of Optometry
Gastroparesis
Effect of Vibrant Capsule on Gastric Emptying and Antropyloroduodenal Motility in Healthy Volunteers
The Vibrant capsule is a novel vibrating device for the treatment of gastrointestinal disorders. The effect of different vibrations on the motor functions of the gastrointestinal tract are unclear.
- Trial name
- NCT02736799
- Testing
- Vibrant Capsule (1 vibration), Vibrant Capsule (3 vibration), Vibrant Capsule (5 vibration)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vibrant Ltd.
Cholecystolithiasis, Cholecystectomy
Does Cholecystectomy Increase the Esophageal Alkaline Reflux? Evaluation by Impedance-pH Technique
Publications with different conclusions are available with regard to the correlations between the cholecystolithiasis, cholecystectomy and gastroesophageal reflux disease (GERD).
- Conditions
- Cholecystolithiasis, Cholecystectomy, Gastroesophageal Reflux
- Trial name
- NCT01047085
- Testing
- impedance pH measurement
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Non-erosive Reflux Disease, Gastroesophageal Reflux
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection
Primary Objective: Evaluate response to NERD treatment between patients with normal endomicroscopy findings compared with patients with abnormal endomicroscopy findings.
- Trial name
- CENERDD (NCT02788591)
- Testing
- Proton Pump Inhibitor (PPI) Therapy, Sucralfate
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- LCMC Health