Clinical trials: Motility Disorder
Nasal Polyps, Gastroesophageal Reflux
Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease
Although nasal polyposis has been recognized as an inflammatory process for many years, the true etiology of nasal polyposis mainly unknown.
- Trial name
- NCT00215787
- Testing
- lansoprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Head and Neck Surgery Associates
Gastroesophageal Reflux
Comparison of Antisecretory Effect of a Single Dose of Rabeprazole 20 mg and Omeprazole 20 mg in Obese Subjects
This study aims to determine, in obese subjects, the antisecretory effect of a single dose of placebo, rabeprazole 20 mg and omeprazole 20 mg using 24h gastric pH monitoring, in a prospective, monocentre, randomized manner.
- Trial name
- Oberab (NCT01136317)
- Testing
- Omeprazole, Rabeprazole, Lactose
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Gastroesophageal Reflux
Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours
First introduced over 40 years ago, the 24-hour catheter-based pH studies have previously been found to be the gold standard in the diagnosis of gastro-oesophageal reflux disease (GORD).
- Trial name
- NCT03417817
- Testing
- Bravo
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Non-Cardiac Chest Pain
The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients
Noncardiac chest pain (NCCP) is a common clinical problem worldwide. In Hong Kong, it has been estimated that about 20% of patients with chest pain are misdiagnosed to have coronary heart disease.
- Trial name
- NCT00164814
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Bronchiectasis, Cystic Fibrosis
Evaluating Bronchodilator Response in Patients With Bronchiectasis
Although patients with bronchiectasis tend to have non reversible obstructive patterns on pulmonary function tests (PFTs), reversible obstruction is not uncommon.
- Conditions
- Bronchiectasis, Cystic Fibrosis, Primary Ciliary Dyskinesia, Primary Immune Deficiency
- Trial name
- NCT05932316
- Testing
- spirometry, Salbutamol
- Where
- Israel
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Convergence Insufficiency
Home Vision Therapy and Prism Prescription in Presbyopic Persons With Convergence Insufficiency
convergence insufficiency is one of the most common binocular vision problems in which the eyes tend to have more exophoria in near than distance activities.
- Trial name
- NCT05311917
- Testing
- home vision therapy, base in prism prescription
- Where
- Iran
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
GERD (Gastroesophageal Reflux Disease)
Study to Evaluate the Effect of Food on the Pharmacokinetics and Pharmacodynamics Characteristics in Healthy Adult Volunteers
A Randomized, Open-label, Oral in healthy volunteers
- Trial name
- NCT07364838
- Testing
- DW4421
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Constipation, Childhood Acute Lymphoblastic Leukemia
Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation
To gain a better understanding of the underlying dysmotility in constipation in children, we will use a novel minimal invasive method called 3D Transit.
- Conditions
- Constipation, Childhood Acute Lymphoblastic Leukemia, Neurofibromatosis 1, Chronic Constipation With Overflow
- Trial name
- NCT03981510
- Testing
- 3D-Transit
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Multiple Sclerosis, Clinically Isolated Syndrome
Visual Processing Speed and Objective Analysis of Ocular Movements in Multiple Sclerosis
This project aims to analyze ocular motility problems, visual processing speed and microperimetry, and their relationship with consolidated retinal structural biomarkers (optical coherence tomography, OCT) in patients with…
- Conditions
- Multiple Sclerosis, Clinically Isolated Syndrome, Relapsing Remitting Multiple Sclerosis, Progressive Multiple Sclerosis
- Trial name
- NCT05706220
- Testing
- Eye tracking, Microperimetry, Optical coherence tomography (OCT)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Esophageal Motility Disorders
Codeine on Pharyngeal and Esophageal Motility
Opioids act on opioid receptors located in the brain as well as in the gastrointestinal (GI) tract to induce changes in motility.
- Trial name
- NCT03784105
- Testing
- Codeine Phosphate, Siripus simplex
- Where
- 2 sites in Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthma, COPD
Acoustic Waveform Respiratory Evaluation
The study will evaluate the feasibility of using smartphone speakers and microphones to evaluate the caliber of the airways, detect airway obstruction, aid in airway disease diagnosis, and identify disease exacerbations.
- Conditions
- Asthma, COPD, Cystic Fibrosis, Ciliary Motility Disorders
- Trial name
- AWARE (NCT06512064)
- Testing
- AWARE
- Where
- 2 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Achalasia
Achalasia: Mechanisms Underlying Treatment Failure
In patients with achalasia, the relationship between the perception of dysphagia, oesophageal emptying, lower oesophageal sphincter (LOS) distensibility and oesophageal circular and longitudinal muscle contraction is not clear.
- Trial name
- NCT02055469
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Gastroesophageal Reflux Disease (GERD), Eosinophilic Esophagitis (EoE)
Mucosal Impedance in Pediatric Population
Our hypothesis is that patients with GERD and/or Eosinophilic Esophagitis (EE) have lower esophageal impedance measurements when compared to patients who do not have GERD or EE.
- Conditions
- Gastroesophageal Reflux Disease (GERD), Eosinophilic Esophagitis (EoE), Functional Dyspepsia
- Trial name
- NCT02320981
- Testing
- Standard of Care esophagogastroduodenoscopy (EGD) with measurement of mucosal impedance
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Gastroparesis
Antro-pyloro-duodenal Motility in Idiopathic Gastroparesis
Impaired gastric emptying may cause dyspeptic symptoms including nausea, vomiting and even nutritionnal impairment. Delay in gastric emptying may result from antro-pyloro-duodenal motility impairement.
- Trial name
- NCT01519180
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Gastrointestinal Diseases, Stomach Diseases
A Comparison of SmartPill Capsule With Scintigraphy for Determining Gastric Residence Time
The purpose of this study is to determine the correlation between gastric residence time of the SmartPill Capsule and the time required for partial emptying of a standard radiolabeled meal as measured by gastric emptying…
- Conditions
- Gastrointestinal Diseases, Stomach Diseases, Gastroparesis
- Trial name
- NCT00128284
- Where
- 7 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- The SmartPill Corporation
Strabismus, Exotropia
Validation of a Smartphone-based Intelligent Diagnosis and Measurement for Strabismus
The current measurement methods of strabismus include the corneal light reflection method, prism alternate covering, etc., which especially rely on the subjective experience of doctors, and there is a large error between…
- Conditions
- Strabismus, Exotropia, Esotropia, Vertical Strabismus
- Trial name
- NCT05615519
- Testing
- A new technology based on 3D reconstruction and deep learning algorithm to achieve an automatic diagnosis of strabismus based on patient-sourced videos of programmatic cover tests.
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Functional Colonic Disease, Fecal Incontinence
Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility
The purpose of this study is to evaluate the effect of sacral nerve magnetic stimulation on the colonic motility in healthy subjects, in incontinent and constipated patients.
- Trial name
- NCT00213317
- Testing
- lombo-sacral magnetic stimulation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Gastroesophageal Reflux, GERD
Influence of Central Obesity on the Esophageal Epithelial Barrier
This study is being done to help understand why some people with an increased amount of central obesity, without gastroesophageal reflux, develop changes to the lining of their esophagus that can potentially lead to esophageal…
- Trial name
- NCT02776982
- Testing
- Confocal endomicroscopy, Mucosal impedance, Research biopsies
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Primary Ciliary Dyskinesia
Functional Studies of Novel Genes Mutated in Primary Ciliary Dyskinesia II: Genotype to Phenotype
The purpose of this study is to measure mucociliary clearance (MCC) in groups of subjects with the disease Primary Ciliary Dyskinesia (PCD) caused by mutations in different genes, and compare to healthy subjects.
- Trial name
- NCT04901715
- Testing
- Albuterol, Technetium99m - Sulfur Colloid (Tc99m-SC)
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gastro Esophageal Reflux
Effect of Citalopram on Reflux Episodes in Healthy Volunteers
Citalopram is sometimes used in the treatment for gastro-esophageal reflux disease, however, there are no empirical data to support this.
- Trial name
- NCT03746691
- Testing
- Citalopram HCl
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven