Clinical trials: Motility Disorder
Gastroesophageal Reflux Disease, Severity
Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries
This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.
- Conditions
- Gastroesophageal Reflux Disease, Severity, Dental Caries
- Trial name
- NCT07108751
- Testing
- Endoscopy
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tanta University
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease
Morphological Markers of Gastroesophageal Reflux Disease (GERD)
The purpose of this project is to learn more about a new and promising way to diagnose acid reflux disease using a very high-powered microscope.
- Trial name
- NCT01921686
- Testing
- Sample collection and Questionnaire
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Pharmacokinetics, Cardiodynamic ECG
A Study to Investigate the Pharmacokinetics and ECG Effects of Linaprazan Glurate
This is a Phase I, single-center, double blind, placebo-controlled, parallel-group, randomized trial designed to evaluate the PK, cardiodynamic ECG effects, safety, and tolerability of single oral doses of linaprazan glurate.
- Conditions
- Pharmacokinetics, Cardiodynamic ECG, Safety, and Tolerability, GERD
- Trial name
- NCT05469854
- Testing
- Linaprazan glurate
- Where
- Sweden
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Aspiration, Gastroesophageal Reflux
Pepsin As A Biomarker For Aspiration
Evaluation of tracheal pepsin as a biomarker for aspiration
- Trial name
- NCT00865995
- Testing
- Tracheal Lavage
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Paresis
Bupivacaine Versus Ropivacaine on Diaphragmatic Motility and Ventilatory Function
Background: Outpatient continuous interscalene brachial plexus blocks are used to control pain after shoulder surgery, with infusions of 0.125% bupivacaine or 0.2% ropivacaine.
- Trial name
- NCT02059070
- Testing
- Ropivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Anesthesiology WSU/DMC-NorthStar
Valvular Heart Disease Stenosis and Regurgitation, Valvular Heart Disease
Screening of Valvular Heart Disease Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 1000 patients over 18 years old in the training sample and 200 patients over 18 years old in the test…
- Trial name
- NCT07099417
- Testing
- No intervention (observational study)
- Where
- Russia
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome
Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies
The purpose of this study is to identify genes associated with impaired development and function of the cranial nerves and brainstem, which may result in misalignment of the eyes (strabismus) and related conditions.
- Conditions
- Congenital Fibrosis of Extraocular Muscles, Duane Retraction Syndrome, Duane Radial Ray Syndrome, Mobius Syndrome
- Trial name
- NCT03059420
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
GERD
Investigate Linaprazan Glurate/Linaprazan in Healthy Subjects
This is a Phase I, single-center, open label parallel-group, randomized study designed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD, by continuous intragastric pH measurment), safety and tolerability of single and…
- Trial name
- NCT05742984
- Testing
- linaprazan glurate 25 mg QD, linaprazan glurate 50 mg QD, linaprazan glurate 75 mg QD
- Where
- Slovenia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Gastric Motility Disorder
Effect of Methylnaltrexone on GI Transit in Healthy Volunteers
This is a single-center, randomized, double blind, placebo-controlled study evaluating the effects of placebo, codeine, methylnaltrexone and codeine with methylnaltrexone on gastrointestinal motility and colonic transit of solids…
- Trial name
- NCT01055704
- Testing
- Methylnaltrexone only, Codeine only, Methylnaltrexone + codeine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Barretts Esophagus With Dysplasia
The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett's Esophagus
This study evaluates the addition of an alginate based solution to twice daily proton pump inhibitor therapy (PPI) in patients undergoing ablative therapy for dysplastic Barrett's esophagus.
- Trial name
- NCT03193216
- Testing
- Alginates
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alzheimer's Disease (AD), Parkinson's Disease (PD)
Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects
The goal of this study is to assess [18F]MNI-777 PET imaging as a tool to detect tau pathology in the brain of individuals who carry a clinical diagnosis of a tauopathy, including: Alzheimer's Disease (AD),Parkinson's disease…
- Conditions
- Alzheimer's Disease (AD), Parkinson's Disease (PD), Chronic Traumatic Encephalopathy (CTE), Progressive Supranuclear Palsy (PSP)
- Trial name
- NCT02103894
- Testing
- [18F]T807 ([18F]MNI-777)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
GERD, Obesity
Impact of Weight Loss on Gastroesophageal Reflux Disease in Overweight and Obese Subjects: a Prospective Study
By affecting the gastroesophageal pressure gradient, obesity predisposes to reflux of gastric contents. The investigators hypothesized that the loss of weight will decrease this gradient and as a result decrease the severity and…
- Trial name
- NCT01574573
- Testing
- Self support, group sessions
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Midwest Biomedical Research
Gastroesophageal Reflux, Heartburn
Esomeprazole and Gastric Emptying of Beer
To investigate the effect of 20 mg esomeprazole daily for one week on gastric emptying of 500 ml beer, the consecutive blood alcohol levels, the gastroesophageal reflux and plasma levels of gastrin and CCK in a randomized…
- Trial name
- NCT00472550
- Testing
- esomeprazole 20 mg
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
MTBI - Mild Traumatic Brain Injury
Validation of Clinical Outcome Measures Specific to mTBI-Related Oculomotor Disorders
The specific aim of this project is to validate clinical tests to be used as outcome measures in studies of mTBI-related vision problems.
- Trial name
- NCT07282691
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Salus University
Gastroesophageal Reflux
Gastroesophageal Reflux Disease Among College Students
Background: Gastroesophageal reflux disease (GERD) is a worldwide prevalent gastrointestinal disorder which has negative impacts on quality of life, health and economy.
- Trial name
- NCT04034017
- Testing
- no intervention
- Where
- Saudi Arabia
- Volunteers
- 2,878 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Gastroparesis
Effect of Vibrant Capsule on Gastric Emptying and Antropyloroduodenal Motility in Healthy Volunteers
The Vibrant capsule is a novel vibrating device for the treatment of gastrointestinal disorders. The effect of different vibrations on the motor functions of the gastrointestinal tract are unclear.
- Trial name
- NCT02736799
- Testing
- Vibrant Capsule (1 vibration), Vibrant Capsule (3 vibration), Vibrant Capsule (5 vibration)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Vibrant Ltd.
Paraesophageal Hernia
Fundoplication in Laparoscopic PEH Repair Based on FLIP
Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.
- Trial name
- PEHFLIP (NCT05807763)
- Testing
- Laparoscopic paraesophageal hernia repair without fundoplication
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Foundation for Surgical Innovation and Education
Functional Colonic Disease, Fecal Incontinence
Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility
The purpose of this study is to evaluate the effect of sacral nerve magnetic stimulation on the colonic motility in healthy subjects, in incontinent and constipated patients.
- Trial name
- NCT00213317
- Testing
- lombo-sacral magnetic stimulation
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
GERD
A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects
A Study to compare Pharmacokinetics, Pharmacodynamics and safety of CKD-381 and D027 in healty subjects
- Trial name
- NCT03211143
- Testing
- CKD-381, Nexium
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Healthy, Obesity
The Effect of Bitter Taste Receptor Agonists on The Gastrointestinal Tract, Hunger and Food Intake
In this study, the investigators aimed at evaluating the role of bitter taste receptors in the gastrointestinal tract (GIT). Intragastric or intraduodenal administration of denatonium benzoate (DB) or quinine hydrochloride were…
- Trial name
- NCT02759926
- Testing
- Denatonium benzoate, Quinine hydrochloride, Tap water
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven