Clinical trials: Motor Deficit
Cerebral Palsy
Evaluating Wearable Robotic Assistance on Gait
The overarching goal of this study is to improve mobility in individuals with movement disorders through advances in wearable assistance (i.e. powered orthoses).
- Trial name
- NCT04119063
- Testing
- powered orthosis
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Attention Deficit Hyperactivity Disorder
Motor Performance in Children With Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children. Children with ADHD have difficulties with co-contraction, producing muscle force, and regulating movement…
- Trial name
- NCT05897437
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Healthy, Neuromuscular Disease
Electromyography to Diagnose Neuromuscular Disorders
This study will investigate problems with muscle weakness and control using electromyography-a test of nerve-muscle cell communication.
- Conditions
- Healthy, Neuromuscular Disease, Postpoliomyelitis Syndrome
- Trial name
- NCT00004553
- Testing
- Electromyography
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Memory Deficits, Aging
The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.
The aim of this project is to estimate the effects of therapy with dance and movement and Tai Chi on irisin plasma levels, a myokine with proven neuroprotective effects, in the context of baseline levels of cognitive function and…
- Conditions
- Memory Deficits, Aging, Cognitive Impairment, Physical Activity
- Trial name
- NCT05363228
- Testing
- Therapy by Dance and Movement, Tai Chi
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Neurologic Deficits, Neurologic Disorder
NeuroSeq: A Prospective Trial to Evaluate the Diagnostic Yield of Whole Genome Sequencing (WGS) in Adult Neurology
Prospective, multi-site, single-arm study to evaluate the diagnostic yield of cWGS in adults with neurological disorders. A single cohort naive of genetic testing will receive standard of care testing for 180 days followed by…
- Conditions
- Neurologic Deficits, Neurologic Disorder, Neurologic Abnormalities
- Trial name
- NeuroSEQ (NCT04170985)
- Testing
- clinical Whole Genome Sequencing
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Illumina, Inc.
Endocarditis
Retrospective Review of Management of Infective Endocarditis
This is an analysis of the outcomes of patients having undergone surgical intervention for infective endocarditis.
- Trial name
- NCT00579761
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Attention Deficit Hyperactivity Disorder (ADHD)
Brain Activity in Adults With ADHD During Neuropsychological Tasks
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.
- Trial name
- NCT02578342
- Testing
- MRI
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Aarau
Iron Absorption
The Effects of Acute Erythropoietin on Hepcidin and Dietary Iron Absorption Following Military-relevant Exercise in Energy Deficit: Pilot Study
Military personnel frequently experience declines in iron status during training and when in the field, which may compromise performance.
- Trial name
- IRON BOOST (NCT07517562)
- Testing
- Exercise test
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Pediatric Obesity
Appetite Response to Exercise- Versus Mixed (Exercise + Dietary Restriction)-Induced Energy Deficit in Adolescents With Obesity
The aim of the present study is to compare the effect of iso-energetic energy deficits induced by energy restriction alone or exercise + dietary restriction (Mixed deficit) on energy intake and appetite feelings in adolescents…
- Trial name
- IDEX2 (NCT04734639)
- Testing
- CON . control condition without exercise / rest condition, Def-Mixed. Condition with a mixed energy deficit induced by exercise + dietary restriction., Def-EI. Condition with an energy-restriction energy deficit
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Aggression, Conduct Disorder
Real-time fMRI for the Treatment of Aggressive Behavior in Adolescents
The purpose of this study is to determine whether real-time fMRI feedback is effective in the treatment of aggressive behavior problems in adolescents with high callous unemotional traits when compared to treatment as usual.
- Trial name
- NCT02563145
- Testing
- Real-time fMRI feedback, Treatment as usual
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Exercise, Gait
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
Researchers at the University of North Carolina at Greensboro conduct a single-arm intervention trial to investigate the efficacy of a music-based group exercise program for community-dwelling older adults.
- Conditions
- Exercise, Gait, Cognitive Decline, Caregiver Burden
- Trial name
- REECO (NCT05462977)
- Testing
- Group exercise program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Child Development
KeySteps@JC Phase One Follow-up Study
This proposed study is a 5-year follow-up study of "KeySteps Phase One Study", which focused on bridging the gap between students from privileged and underprivileged families.
- Trial name
- NCT05778669
- Testing
- Monitoring of medical, health and psychosocial conditions
- Where
- Hong Kong
- Volunteers
- 1,486 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Caloric Restriction, Exercise
Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
The objective of this study is to determine whether maintaining a eugonadal state, during severe, sustained energy deficit, attenuates physiological decrements, particularly the loss of lean body mass.
- Trial name
- OPS (NCT02734238)
- Testing
- Sesame Oil, testosterone enanthate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
ADHD
The Effects of a Single Dose of Methylphenidate on Motor Performance
Aim: To evaluate the effects of MPH on young adults diagnosed with ADHD on different exercise performance tests. Hypothesis: MPH will have positive effects on motor tests requiring concentration.
- Trial name
- NCT04283604
- Testing
- MPH
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Loewenstein Hospital
Amyotrophic Lateral Sclerosis
Brain Excitability and Connectivity in Sensory-motor Pathways in ALS
The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology.
- Trial name
- SOM_ALS (NCT03694132)
- Testing
- functional MRI, structural MRI, EEG/MEG
- Where
- France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aggression, Conduct Disorder
Arousal-Biofeedback for the Treatment of Aggressive Behavior in Children and Adolescents
The purpose of this study is to determine whether individualized biofeedback of arousal (skin conductance) is effective in the treatment of aggressive behavior problems in children and adolescents with either predominantly…
- Conditions
- Aggression, Conduct Disorder, Oppositional Defiant Disorder
- Trial name
- NCT02485587
- Testing
- Individualized Arousal-Biofeedback, Treatment as usual
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Central Institute of Mental Health, Mannheim
Stroke, Acute, Stroke (Subacute)
Inter-Limb Transfer in Acute Stroke
This study aims to investigate whether the improvements achieved through motor skill learning (MSkL) with the ipsilesional upper limb (UL) are transferred to the contralesional UL during the (sub)acute stroke phase, and to…
- Conditions
- Stroke, Acute, Stroke (Subacute), Healthy Individuals (Controls), Chronic Stroke Patients
- Trial name
- MLAS5 (NCT07822633)
- Testing
- REAplan®, Dextrain Manipulandum®
- Where
- 2 sites in Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Alzheimer Disease, Traumatic Brain Injury
Olfactory Deficits in Neurologic Disease
The goal of this study is to examine olfactory function in preclinical subjects or individuals with neurological diseases such as Probable Alzheimer's Disease (PRAD), Frontotemporal Dementias (FTD), Dementia with Lewy Bodies…
- Conditions
- Alzheimer Disease, Traumatic Brain Injury, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
- Trial name
- NCT05019014
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Functional Recovery, Motor Rehabilitation
Cervical TsDCS on Stroke Patients
The present project aims to evaluate the facilitatory modulation of motor responses of the limb upper limb by tsDCS in patients with arm/hand hyposthenia after cerebral ischemia to verify the possible therapeutic benefits that…
- Trial name
- AMPLI-MOV (NCT06826274)
- Testing
- tDCS
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma