Clinical trials: Motor Function of Healthy Physiology
Mild Cognitive Impairment, Alzheimer Disease
Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson Disease, Healthy Volunteers
- Trial name
- Brain-Muscle (NCT02253732)
- Testing
- 3 months exercise intervention program
- Where
- 2 sites in Slovakia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Healthy
Nervous System Function in Normal Volunteers During Cycling Training
This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task.
- Trial name
- NCT00055588
- Testing
- Locomotor training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Exercise, Square Step Exercises
Square Step Exercises in Healthy Young Adults
This study aims to compare the effectiveness of Square Stepping Exercise and aerobic exercise on cognitive function and physical fitness in young adults.
- Conditions
- Exercise, Square Step Exercises, Aerobic Exercise, Cognitive Function
- Trial name
- NCT06331078
- Testing
- Square Stepping Exercise training, Aerobic Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fenerbahce University
Cardiovascular Risk Markers, Postprandial Metabolism
Exercise Intensity and Postprandial Effects of Breaking Sedentary Behavior in Overweight Adults
The purpose of this study is twofold: (1) to determine whether breaking up prolonged sitting with aerobic or sprint cycling breaks reduces postprandial blood glucose, insulin, CRP, and blood pressure, which are established risk…
- Conditions
- Cardiovascular Risk Markers, Postprandial Metabolism, Exercise Physiology, Substrate Oxidation
- Trial name
- NCT07229963
- Testing
- Aerobic Exercise Intervention, Sprint Exercise Intervention, Sedentary Behaviour Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Moyamoya Disease, Healthy
Cognitive-Motor Incorporated Training and Its Relations in Cerebrovascular Diseases With Cognitive and Motor Impairments
The following three-part proposal will explore the impact of applying motor-cognitive incorporated training (MCIT) in individuals with post-stroke cognitive impairment (PSCI) or Moyamoya disease (MMD), and examine the…
- Conditions
- Moyamoya Disease, Healthy, Stroke
- Trial name
- NCT07144930
- Testing
- MCIT program, Motor training program
- Where
- Taiwan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Physical Exertion
Acute Exercise and Microvascular Function
It is well recognized that chronic exercise protects against the development of cardiovascular diseases. However, the responses of vasculature to acute exercise (AE) are not well known and not consistent in literature.
- Trial name
- NCT02727439
- Testing
- Acute Exhausting Exercise (AE)
- Where
- Croatia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Stroke, Healthy Adults
Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function in Patients With Stroke
This study aims to compare the effects of mirror therapy combined with either neuromuscular electrical stimulation or binaural beat stimulation on post-stroke lower limb motor function recovery.
- Trial name
- NCT06011018
- Testing
- Mirror Therapy, Mirror Therapy + Electrical Stimulation, Mirror Therapy + Binaural Beat
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Motor Activity
The Influence of Laterality on the Performance of Healthy Women in Selected Standardized Tests
The aim of the research study is to find out how the results of healthy women aged 20-24 years (inclusive) differ in the Nine Peg Test, the Purdue Pegboard Test and the Box and Block Test, depending on the laterality of the…
- Trial name
- NCT05661617
- Testing
- Nine Hole Peg Test, Purdue Pegboard Test, Box and Block Test
- Where
- Czechia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment
"Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients"
"This study aims to investigate ultrasonographic parameters of the median nerve in healthy individuals and patients with mild and moderate carpal tunnel syndrome (CTS).
- Conditions
- Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment, Electrophysiologic Study, Ultrasound
- Trial name
- NCT07408596
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Multiple Sclerosis, Healthy Controls Group - Age and Sex-matched
Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in Multiple Sclerosis
Walking and motor control impairments are among the most common manifestations experienced by people with multiple sclerosis (pwMS) and may already be present in individuals with mild disability.
- Trial name
- NCT07505355
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Athletic Performance, Exercise
Endurance Trial: Ketone and Carbohydrate Supplementation
This randomized, double-blind, crossover study investigates the effects of exogenous ketone supplementation on physical and cognitive performance in amateur endurance athletes during exhaustive exercise.
- Conditions
- Athletic Performance, Exercise, Ketosis, Cognition
- Trial name
- NCT07792876
- Testing
- Carbohydrate beverage, (R)-1,3-butanediol, Standardized evening meal
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy Volunteers
Physiological Effects of High-flow Nasal Cannula During Exercise
The high-flow nasal cannula (HFNC) has increased its evidence in patients during pulmonary rehabilitation. These studies hypothesize that the physiological effects of HFNC (positive expiratory pressure, anatomical dead space…
- Trial name
- NCT05550935
- Testing
- High-flow Nasal Cannula
- Where
- Chile
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Transcranial Direct Current Stimulation
Effects of Transcranial Direct Current Stimulation After Short-term Immobilization on Motor Learning and Hand Function in Healthy Young Adults
The purpose of the study is to investigate the effects of short-term braking on the motor learning and fine motor skills of healthy adults, and to analyze whether transcranial direct current stimulation can alleviate the effects…
- Trial name
- NCT07089056
- Testing
- transcranial direct current stimulation, immobilization
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Brain Tumor, Brain Cancer
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients With Brain Tumors
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much…
- Conditions
- Brain Tumor, Brain Cancer, Motor Cortex; Lesion
- Trial name
- NCT05023434
- Testing
- Intraoperative Brain Simulation - Alternate Stimulation Parameters
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Neuromuscular Diseases
Muscle Oxygenation in Effort in Neuromuscular Diseases
Previous studies showed modifications of muscle oxygenation parameters in muscular dystrophies du to an impairment or an absence of dystrophin.
- Trial name
- OXYNEMU (NCT02789059)
- Testing
- muscle oxygenation
- Where
- 3 sites in France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Healthy Night Shift Workers
Light and Exercise in Night-shift Workers
EuRhythDia is a multicenter, controlled and randomized study. The aim of the study is to investigate the effects of 12 weeks of randomized timed light therapy or timed physical exercise as a chronotherapeutic lifestyle…
- Trial name
- NCT01767181
- Testing
- Intensive light therapy, Exercise
- Where
- Germany
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Oxidative Stress, Inflammation
Effects of Magnesium and Spinning Training on Echocardiographic, Inflammatory, and Aerobic Outcomes
Regular aerobic exercise may improve cardiorespiratory fitness while modulating systemic inflammation and oxidative stress. Spinning, as a structured indoor cycling modality, provides a practical aerobic exercise model with…
- Conditions
- Oxidative Stress, Inflammation, Physical Fitness, Echocardiography
- Trial name
- NCT07662954
- Testing
- Spinning Training, Magnesium Supplementation
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Karamanoğlu Mehmetbey University
Healthy
Use of Real-Time Functional Magnetic Resonance Imaging Neurofeedback to Improve Motor Function in Cerebellar Ataxia
This project will study the feasibility of motor rehabilitation in people with cerebellar ataxia using real-time functional magnetic resonance imaging neurofeedback (rt-fMRI NF) in conjunction with motor imagery.
- Trial name
- fMRI (NCT05436249)
- Testing
- Neurofeedback treatment, At-home therapy
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Normal Physiology on Healthy Subjects
Effects of Glucose-fructose Drinks During Training on Lactate Transport
The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.
- Trial name
- LactEx (NCT01610986)
- Testing
- Glucose-fructose, Water
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Lausanne