Clinical trials: Motor Recovery
Stroke
A Study to Evaluate the Safety and Efficacy of Basmisanil in Adults With Severe Motor Impairment Following an Ischemic Stroke
This Phase IIa, randomized, double-blind, placebo-controlled, parallel group study will evaluate the safety, efficacy and pharmacodynamics of basmisanil in adult participants with severe motor impairment following an ischemic…
- Trial name
- NCT02928393
- Testing
- Basmisanil
- Where
- 13 sites in France, Spain
- Volunteers
- 5 people
- Sponsor
- Hoffmann-La Roche
Stroke, Cerebrovascular Accident
Enhancing Plasticity in Stroke Patients With Severe Motor Deficit
This study will evaluate the effectiveness of sustained peripheral nerve stimulation coupled with functional motor training, to improve hand motor function in poorly recovered stroke patients.
- Trial name
- NCT02633215
- Testing
- S88 Dual Output Stimulator by Grass Technologies
- Volunteers
- 36 people
- Sponsor
- Lumy Sawaki
Peripheral Nerve Injuries
Registry of Avance® Nerve Graft's Utilization and Recovery Outcomes Post Peripheral Nerve Reconstruction
This study is a registry of general use of Avance Nerve Graft and is intended to evaluate the uses, response rates, and safety of Avance Nerve Graft in the real-life clinical setting.
- Trial name
- RANGER® (NCT01526681)
- Testing
- Processed Human Nerve Graft, Standard Treatment, Autogenous Nerve Graft, Direct Suture, etc., Autogenous Nerve Graft
- Where
- 49 sites in United States, Austria and 2 more
- Volunteers
- 3,126 people
- Sponsor
- Axogen Corporation
Stroke
Multisite Transcranial Direct Current Stimulation to Promote Hand Function Recovery After Stroke
A novel multisite high definition tDCS (HD-tDCS) in healthy people showed that such network-targeted stimulation could enhance motor excitability beyond traditional stimulation which targeting only one region.
- Trial name
- NCT05638464
- Testing
- multisite HD-tDCS EMG-driven robot hand
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stroke
Comparative Effects of Mirror Therapy, Proprioceptive Neuromuscular Facilitation, and Constraint-Induced Movement Therapy on Upper Limb Motor Recovery in Stroke Survivors: A Three-Arm Randomized Controlled Trial
This study aimed to compare the effects of these three interventions on upper limb motor recovery in stroke survivors. A three-arm randomized controlled trial was conducted in which eligible participants (N=90) with post-stroke…
- Trial name
- NCT07683130
- Testing
- mirror therapy, PNF, Constraint-induced movement therapy
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Foundation of Medical Research and Laboratories, Pakistan
Gestational Diabetes, Mobile Application
eHealth in Treatment of Gestational Diabetes (eMOMGDM)
The overall aim of the eMOM GDM-project is to develop and evaluate a novel system to clinical decision making and patient behavior change in treatment of GDM, combining diet, physical activity, sleep, heart rate (e.g.
- Trial name
- eMOMGDM (NCT04714762)
- Testing
- eMOM GDM application
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Stroke
Cortical Ischemic Stroke and Serotonin
In this study the investigators want to test the hypotheses that, serotonergic neuromodulation increases perilesional neuroplasticity, leading to improved behavioural outcomes through a more efficient allocation of functional…
- Trial name
- CISS (NCT02865642)
- Testing
- Serotonin Uptake Inhibitors
- Where
- 2 sites in Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Physical Exercise
Penyagolosa Trail Saludable 2025
The research team leading this project frames it within the objective of advancing knowledge about what happens to this group of athletes who participate in Ultratrail events, with the particularity of studying them during the…
- Trial name
- PTS2025 (NCT06969898)
- Testing
- Single Ultramarathon runners
- Where
- Spain
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Colon Cancer, Rectal Cancer
Promoting Physical Activity After Colorectal Cancer
Colorectal cancer is the third most common cancer in the U.S. and if detected early, has a favorable prognosis. Colorectal cancer survivors report increased fatigue, low vigor, impaired physical functioning and disturbances in…
- Trial name
- NCT00230646
- Testing
- Exercise counseling
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The Miriam Hospital
Stroke
The Effect of Scapular Stabilization Exercises on the Upper Extremity in Patients With Chronic Stroke
There is still no approved exact treatment for stroke, one of the leading causes of disability. Neurorehabilitation is an important treatment option for stroke patients with anatomical and functional impairments in their…
- Trial name
- NCT05609136
- Testing
- Bobath+Scapular Stabilization Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Suleyman Demirel University
Parkinson's Disease, Drug-induced Parkinsonism
Effect of Exercise in Parkinsonism
Parkinson's disease (PD) is a common neurodegenerative disorder affecting approximately 80,000 Veterans, representing a priority area for VA research.
- Trial name
- NCT02598973
- Testing
- Exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Severe Mental Disorder
Development and Evaluation of an Intervention (AiMH) for People With Severe Mental Illness Living in Supported Housing
People with severe mental illness (SMI) spend a great amount of time in their homes. The home is thus of vital importance for an everyday life with meaningful activities.
- Trial name
- NCT05157854
- Testing
- Active in My Home (AiMH)
- Volunteers
- 72 people
- Sponsor
- Lund University
Stroke
Transcranial Direct Current Stimulation to Improve Hand Movement in Stroke Patients
This study will examine whether hand movement in stroke patients can be improved by applying electrical stimulation to the side of the brain affected by the stroke.
- Trial name
- NCT00307385
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy
The Impact of Protein Intake on Protein Metabolism During Intensified Training
Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).
- Trial name
- NCT02801344
- Testing
- Normal, Moderate, High
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Ischaemic Stroke
Combined tDCS+PNS After Acute Stroke
Recent work showed that application of peripheral nerve and cortical stimulation independently can induce 10-15 % improvement in motor performance in patients with chronic stroke.
- Trial name
- NCT01207336
- Testing
- combined transcranial direct current stimulation and electrical peripheral nerve stimulation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Surgery--Complications, Abdomen
A Real-world Study to Examine the Relationship Between Simple Physical Functioning Tests, Complications and Recovery Following Abdominal Surgery.
Background: Complications impact physical and psychological recovery and are associated with financial cost. General physical function has not been studied in relation to the development of surgical complications in this cohort.
- Conditions
- Surgery--Complications, Abdomen, Physical Activity
- Trial name
- NCT03930784
- Testing
- Nil intervention
- Volunteers
- 49 people
- Sponsor
- University Hospital of Limerick
Long COVID, Long Covid19
RECOVER-ENERGIZE Platform Protocol_Appendix B (Structured Pacing (PEM))
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06404073
- Testing
- Structured Pacing, Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Acute Stroke
Mirror Therapy for Hand Function Recovery in Acute Stroke
Randomized controlled trial to determine whether mirror therapy (MT), added to conventional physiotherapy, improves upper-limb motor recovery, hand function, spasticity, and range of motion (ROM) in acute stroke compared with…
- Trial name
- Stroke (NCT07204067)
- Testing
- Mirror Therapy Conventional Physiotherapy
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Riphah International University
Stroke, Ischemic, Upper Limb Injury
MOdularity for SEnsory Motor Control
For this project the investigators ask, how the activation and organization of muscle synergies may be disrupted by brain lesions, and whether it is possible to modify synergy activations by means of specific therapies.
- Conditions
- Stroke, Ischemic, Upper Limb Injury, Rehabilitation
- Trial name
- MOSE (NCT03530358)
- Testing
- Technology-aided rehabilitation, Conventional rehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 132 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy