Clinical trials: Motor Recovery
Stroke, Upper Extremity Paresis
Deep Brain Stimulation of the Dentate Nucleus for Motor Rehabilitation After Stroke
The goal of this clinical trial is to learn if deep brain stimulation of the dentate nucleus (DN-DBS) works to promote chronic post-stroke upper limb motor function in adults. It will also learn about the safety of DN-DBS.
- Trial name
- NCT06498934
- Testing
- deep brain stimulation, Rehabilitation
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Beijing Municipal Administration of Hospitals
Stroke, Hemiparesis
Translating Intensive Arm Rehabilitation in Stroke to a Telerehabilitation Format
Loss of arm use and strength are common problems after stroke that greatly affects independence in activities of daily living. Arm rehabilitation using robot-assisted repetitive task training has shown to improve motor recovery.
- Trial name
- TeleBATRAC (NCT02665052)
- Testing
- Home-Based BATRAC plus TTT, Lab-based BATRAC plus TTT, Delayed Entry Usual Care
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Stroke, Hemiplegia
Effects of Intermitted Theta Burst Stimulation (iTBS) on Motor Recovery of Upper Extremity in Chronic Stroke Patients
This study aims to evaluate the effects and clinical feasibility of non-invasive brain stimulation protocols, specifically intermittent Theta Burst Stimulation, as part of rehabilitation interventions for motor recovery of upper…
- Conditions
- Stroke, Hemiplegia, Hemiparesis After Stroke, Hand Functionality
- Trial name
- NIMBLE (NCT07073248)
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Danderyd Hospital
Spinal Cord Injury
The Effect of rTMS in Patients With Spinal Cord Injury (rTMS:Repetetive Transcranial Magnetic Stimulation)
It is postulated that high frequency repetitive transcranial magnetic stimulation (rTMS) can decrease the corticospinal inhibition and enhance the motor recovery.
- Trial name
- rTMS: (NCT04372134)
- Testing
- repetitive transcranial magnetic stimulation therapy
- Volunteers
- 28 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Ischemic Stroke
Individual Alpha Frequency-Based rTMS for Post-Stroke Motor Recovery: Efficacy and Neurophysiological Mechanisms
The goal of this clinical trial is to evaluate the efficacy of a personalized brain stimulation technique, Individual Alpha Frequency (IAF)-based rTMS, for motor function recovery in adult patients with a first-ever ischemic…
- Trial name
- NCT07498777
- Testing
- Active Individual Alpha Frequency-based Repetitive Transcranial Magnetic Stimulation (IAF-rTMS)
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- National Taiwan University Hospital
Aging, Acute Care Unit
Evaluation of the Impact of Non-slip Socks on Motor Recovery in the Elderly
Some authors suggest a possible clinical interest of anti-slip socks. The scientific literature presents studies with methodological limitations.
- Conditions
- Aging, Acute Care Unit, Fall Injury
- Trial name
- CHARM (NCT04882696)
- Testing
- Non-slip socks
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Post-partum, Women
Creatine for Recovery and Thinking in Mothers
The purpose of this randomized, double-blind, parallel-group trial is to compare the effects of two doses of creatine monohydrate (5 g/day versus 10 g/day) administered for four weeks in postpartum women.
- Trial name
- CREATE-MOM (NCT07795853)
- Testing
- Creatine Monohdyrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of North Carolina, Chapel Hill
Stroke, Post-stroke Depression
Physical Capacity Building for Chronic Stroke
Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery.
- Trial name
- NCT07039305
- Testing
- Physical capacity training for chronic stroke - building aerobic capacity and muscle strength
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injury, Spinal Cord Injury Subacute
Spinal Stimulation With Gait Training to Improve Lower Limbs Motor Recovery in Spinal Cord Injury
Spinal cord injury (SCI) often results in partial or complete loss of movement. In the subacute phase (< 6 months), the central nervous system shows increased potential for neuroplasticity, making it more responsive to…
- Conditions
- Spinal Cord Injury, Spinal Cord Injury Subacute, Locomotion, Gait Disorder, Sensorimotor
- Trial name
- CIMELocomotion (NCT07375745)
- Testing
- Protocol 2: Gait training combined with an effective tSCS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal
Acute Stroke
Interdisciplinary Home Rehabilitation of Patients With Stroke. A Randomised Controlled Intervention Trial.
Objective: To evaluate the effect of interdisciplinary home rehabilitation of patients with acute stroke. The trial seeks to evaluate: 1.
- Trial name
- NCT00626353
- Testing
- Home-based rehabilitation, Standard care
- Where
- Denmark
- Volunteers
- 71 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Major Depressive Disorder, Depression Moderate
Exercise Recovery From Persistent Depression: A Thematic Analysis
Depression is a leading cause of disability worldwide and poses a large economic burden in the UK. There is evidence that exercise is beneficial in the management of depression and NICE now recommends group exercise programs as a…
- Conditions
- Major Depressive Disorder, Depression Moderate, Depression Severe
- Trial name
- NCT05539495
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Stroke
Interference During Motor Learning of Different Degrees of Freedom in the Paretic Upper Extremity of People With Stroke
Post-stroke rehabilitation of the upper extremity is a challenge in neurorehabilitation. Selective training of different degrees of freedom (training of specific monoarticular movements and in one plane of movement of the upper…
- Trial name
- NCT06249737
- Testing
- Training
- Where
- 2 sites in Spain
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Stroke
Cranial Nerve Neuromodulation to Improve Arm Function and Brain Plasticity in Stroke
Following a stroke, persistent residual muscle weakness in the upper limb (UL) drastically impacts the individuals' quality of life and level of independence.
- Trial name
- CN-NINM (NCT06386510)
- Testing
- Strength training, Cranial nerve non-invasive neuromodulation
- Where
- 3 sites in Canada
- Volunteers
- 74 people
- Sponsor
- Université de Sherbrooke
Stroke, Ischemic, Stroke
Comparison of the Effectiveness of Mirror Therapy and Mirror Mode of Hand Robot in Stroke
The goal of this clinical trial is to compare the effectiveness of conventional mirror therapy and robotic mirror mode training in promoting upper extremity motor recovery in adult patients with ischemic stroke during the early…
- Conditions
- Stroke, Ischemic, Stroke, CVA (Cerebrovascular Accident)
- Trial name
- mirror_robot (NCT07435688)
- Testing
- Hand Robot Mirror Mode, Therapy Mirror
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zeynep Lide Uz
Stroke, Stroke Hemorrhagic
Hand MOtor Rehabilitation Using a EMG-biofeedback: a Cross-sectional Study
Recovery of upper limb and hand gestures is fundamental for autonomy restoration after stroke. Innovative technologies are a valid support for the delivery of rehabilitation treatments.
- Conditions
- Stroke, Stroke Hemorrhagic, Stroke, Ischemic, Hemiparesis
- Trial name
- MORE (NCT04889586)
- Testing
- EMG-biofeedback armband (REMO)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Stroke
Impact of Gait Training on Lower Extremity Motor Function and Balance Performance in Stroke Survivors.
This randomized clinical trial evaluates and compares the effectiveness of three physiotherapy-based rehabilitation strategies in improving gait, motor function, balance, and independence in individuals recovering from stroke.
- Trial name
- NCT07066319
- Testing
- Gait Training with Proprioceptive Neuromuscular Facilitation (PNF), Gait Training with Conventional Physiotherapy, Combined PNF and Conventional Physiotherapy (without direct gait training)
- Where
- Pakistan
- Volunteers
- 99 people
- Sponsor
- University of Lahore
Dental Sedation, Passive Smoking
The Effects of Passive Smoking on Vital Signs, Anxiety, and Recovery Times in Children Undergoing Primary Tooth Extraction Treatment Under Sedation
The aim of this clinical study is to evaluate the effects of passive smoking on the vital parameters of children undergoing primary tooth extraction under sedation and to assess their anxiety levels throughout the process until…
- Trial name
- NCT06780189
- Testing
- Tooth Extraction and Post-Procedure Monitoring Under Sedation in Children Exposed to Passive Smoking, Tooth Extraction and Post-Procedure Monitoring Under Sedation in Children Not Exposed to Passive Smoking
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Rheumatic Diseases, Rheumatoid Arthritis (RA)
Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis
In the context of this randomized controlled study, patients who are diagnosed with Rheumatoid arthritis in Cerrahpaşa Faculty of Medicine Hospital, will be taken into a rehabilitation program by a qualified physiotherapist to…
- Trial name
- NCT07274124
- Testing
- Pain Neuroscience Education, Vagal Nerve Stimulation, Structured Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Medipol University
Hemiparesis, Stroke
A Brain Centered Neuroengineering Approach for Motor Recovery After Stroke: Combined rTMS and BCI Training
The purpose of this study is to determine whether the combination of low frequency repetitive transcranial magnetic stimulation (rTMS) and motor-imagery-based brain computer interface (BCI) training is effective for enhancing…
- Trial name
- NCT02132520
- Testing
- rTMS, BCI Training
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Minnesota
Concussion, Brain
Salivary Biomarkers for Concussion Recovery
The overarching purpose of this proposed research is to determine whether BDNF and/or specific miRNAs can serve as biomarkers for recovery from a concussion during prescribed exercise.
- Trial name
- NCT05379920
- Testing
- High Volume Aerobic Exercise, Low Volume Aerobic Exercise
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo