Clinical trials: Motor Speech
Dementia, Motor Neuron Disease
Digital App for Speech & Health Monitoring
Many people living with neurodegenerative conditions like dementia, motor neuron disease (MND), multiple sclerosis (MS), and Parkinson's disease (PD), suffer from speech problems.
- Conditions
- Dementia, Motor Neuron Disease, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT06450418
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stuttering, Developmental
Investigating Non-invasive Brain Stimulation to Enhance Fluency in People Who Stutter
This study aims to test whether the application of transcranial direct current stimulation (tDCS) concurrent with fluency training results in improvements in speech fluency in adults with developmental stuttering, measured up to…
- Trial name
- INSTEP (NCT03335722)
- Testing
- Metronome-timed speech, Active tDCS
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Amyotrophic Lateral Sclerosis
DESIPHER_Speech Degradation as an Indicator of Physiological Degeneration in ALS
A disease called Amyotrophic lateral sclerosis (or ALS), which leads to difficulty swallowing, breathing, and movement, has been found to be higher for those serving in the military than in the general population.
- Trial name
- NCT02675075
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Speech, Motor Activity
Somesthesic Role of the Ventro-lateral Prefrontal Cortex in Speech Motor Learning
These studies test the hypothesis that frontal areas of the brain participate in the cortical networks involved in the somotosensory processing that happens during speech motor learning.
- Trial name
- BRAVA² (NCT04547569)
- Testing
- Speech adaptation, Vibrotactile Discrimination, fMRI
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
Digital Speech Markers for Monitoring ALS in Spanish Speakers
The goal of this observational study is to learn how speech and breathing change over time in Spanish-speaking individuals with amyotrophic lateral sclerosis (ALS) compared to age- and gender-matched individuals without ALS.
- Conditions
- Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease, ALS
- Trial name
- NCT07341334
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task
Correlations Between Fine Manual Motor Skills and Speech Articulation
The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35.
- Trial name
- MOFiA (NCT06908863)
- Testing
- Tasks learning and MRI scan
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Depression, Anxiety, Physical Activity
Promoting Active Therapy: Path to Wellness
This project will examine changes in depression and anxiety following a 10-week intervention promoting nature-based physical activity in mental health settings.
- Conditions
- Depression, Anxiety, Physical Activity, Time in Nature, Self-Efficacy
- Trial name
- NCT06858189
- Testing
- Walk-and-talk therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kansas State University
Speech
Behavioral and Neural Characteristics of Adaptive Speech Motor Control
This study meets the NIH definition of a clinical trial, but is not a treatment study. Instead, the goal of this study is to investigate how hearing ourselves speak affects the planning and execution of speech movements.
- Trial name
- NCT06164717
- Testing
- Auditory feedback perturbation during speech, Visual feedback perturbation during reaching, DBS stimulation ON/OFF
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- University of Washington
Parkinson Disease
Supplementary Motor Area is a Potential Target for Speech Disturbance in Parkinson Disease
Speech disturbance is common in patients with Parkinson disease. Pharmacotherapy improves motor symptoms but has inconsistent effects on speech disturbance in PD patients.
- Trial name
- NCT05478057
- Testing
- "MAGSTIM" Repetitive transcranial magnetic stimulator (rTMS) system
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Child Development, Child Development Disorder
The Indonesian Version of Ages and Stages Questionnaire III Accuracy Compared to Bayley Scales of Infant Development III
This study aimed to evaluate the concurrent validity information of the 24-, 30-, and 36-month Indonesian ASQ-3 with the Bayley Scales of Infant and Toddler Development 3rd Edition (BSID-III) in Indonesian children.
- Conditions
- Child Development, Child Development Disorder, Development Delay, Developmental Delay
- Trial name
- NCT05408351
- Where
- Indonesia
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Aphasia, Acquired, Aphasia
Aphasia Physical EXercise Study: Randomized Trial
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia.
- Conditions
- Aphasia, Acquired, Aphasia, Aphasia, Fluent, Aphasia, Non-fluent
- Trial name
- APEX (NCT07281313)
- Testing
- High-intensity physical exercise, Low-intensity physical exercise
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of California, Berkeley
Speech
Modulation of Sensory Acuity With Transcranial Magnetic Stimulation (TMS)
The purpose of this research study is to understand how the brain processes and controls speech in healthy people. The investigators are doing this research because it will help identify the mechanisms that allow people to…
- Trial name
- NCT05723575
- Testing
- TMS, somatosensory acuity measurement
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson's Disease
Measures of Motor Impairment in Early Parkinson's Disease
This study will test the accuracy of a new home-use electronic device that measures and records small changes in Parkinson's disease symptoms, such as tremor and impaired movement and speech.
- Trial name
- NCT00291265
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Randomized Controlled Trial for Speech Disorders in Children
Treatment Efficacy for Developmental Motor Speech Disorders
The purpose of this study is to carry out a high-level treatment efficacy study on children with speech sound disorders with motor speech involvement (SSD-MSI) using a well-controlled Randomized Controlled Trial design.
- Trial name
- NCT02105402
- Testing
- PROMPT
- Where
- 3 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- The Prompt Institute
ALS, SCI - Spinal Cord Injury
ECoG BMI for Motor and Speech Control
Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.
- Conditions
- ALS, SCI - Spinal Cord Injury, Stroke, Multiple Sclerosis
- Trial name
- BRAVO (NCT03698149)
- Testing
- PMT/Blackrock Combination Device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Karunesh Ganguly
Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant
Nabilone for Agitation in Frontotemporal Dementia
The primary goal of this study is to test the hypothesis that oral nabilone treatment will reduce agitation compared with placebo in patients with Frontotemporal Dementia (both behavioural variant frontotemporal dementia and…
- Conditions
- Frontotemporal Dementia, Frontotemporal Dementia, Behavioral Variant, Primary Progressive Aphasia, bvFTD
- Trial name
- Nabilone-FTD (NCT05742698)
- Testing
- Nabilone
- Where
- 7 sites in Canada
- Volunteers
- 3 people
- Sponsor
- Simon Ducharme, MD
Childhood Apraxia of Speech, Genetic Condition
Speech Therapy for Children With Rare Genetic Conditions and Childhood Apraxia of Speech
The goal of this trial is to learn if speech therapy can improve speech accuracy in children with rare genetic conditions and childhood apraxia of speech (CAS). This study will look at each child individually.
- Trial name
- NCT07815249
- Testing
- Rapid Syllable Transition Treatment, Dynamic Temporal and Tactile Cueing
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Murdoch Childrens Research Institute
Cerebral Palsy, Dysarthria
Speech Motor Treatment in Cerebral Palsy
Cerebral palsy (CP) is the most frequent cause of motor disability worldwide, with a prevalence of 2-2.5 per 1000 live births. Children with CP may experience a variety of difficulties with communication including speech.
- Trial name
- NCT04189159
- Testing
- PROMPT
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Fondazione Stella Maris
Speech, Consolidation
Sensory Memory in Speech Motor Learning
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal…
- Trial name
- NCT04818268
- Testing
- Adaptation, cTBS
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University