Clinical trials: Mountain Sickness Acute
Acute Mountain Sickness
HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men
Millions of people travel to high altitude for work or leisure activities and are exposed to reduced inspiratory oxygen partial pressure and hypoxemia that may lead to altitude illness, among which the most common form is acute…
- Trial name
- NCT06499727
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness, High Altitude Headache
Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness
The objective of this study is to determine the efficacy of metoclopramide in relieving the symptoms of Acute Mountain Sickness (AMS).
- Trial name
- NCT01522326
- Testing
- Ibuprofen, Metoclopramide
- Where
- Nepal
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Mountain Sickness
Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness
Acute mountain sickness (AMS), high altitude pulmonary edema (HAPE), and high altitude cerebral edema (HACE) are complications of rapid ascent to high altitude.
- Trial name
- NCT00664001
- Testing
- Anti-oxidant supplementation
- Where
- United Kingdom
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Altitude Physiology Expeditions
Acute Mountain Sickness
Inhaled Budesonide and Acute Mountain Sickness
The primary objective of the study is to investigate the effect of inhaled budesonide on the incidence of AMS. The primary study question to ask is: 1.
- Trial name
- NCT02811016
- Testing
- Budesonide 200, Budesonide 800
- Where
- Austria
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Salzburger Landeskliniken
Acute Mountain Sickness
Altitude Sickness Prevention and Efficacy of Comparative Treatments
This study is designed to be the first to examine the novel drug budesonide for prevention of acute mountain sickness in comparison to acetazolamide and in the context of rapid ascent to high altitude.
- Trial name
- ASPECT (NCT02604173)
- Testing
- Budesonide, Acetazolamide
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Stanford University
High-altitude Sleep Disturbance
Comparison of Temazepam and Acetazolamide to Treat Difficulty Sleeping at High Altitude
More than 70% of visitors to high altitude suffer poor sleep. The present study seeks to answer the question: Which medication is associated with better sleep at high altitude: temazepam or acetazolamide? The investigators…
- Trial name
- NCT01519544
- Testing
- Temazepam, Acetazolamide
- Where
- Nepal
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastrointestinal Injury, Acute Mountain Sickness
Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude
The aim of this randomized, crossover clinical trial is to determine the efficacy of a gut microbiota-targeted nutritional intervention containing a blend of fermentable fibers and polyphenols (FP) for mitigating increases in GI…
- Trial name
- NCT04111263
- Testing
- FP, High altitude, Sea level
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Acute Mountain Sickness
Voluntary Isocapnic Hyperpnea in Hypoxia to Mitigate Acute Mountain Sickness
This study investigates the effects of a brief Voluntary Isocapnic Hyperpnoea (VIH) on Acute Mountain Sickness (AMS) symptoms, SpO₂, blood pressure, and blood gas homeostasis in normobaric hypoxia, to evaluate whether such…
- Trial name
- NCT07126834
- Testing
- VIH
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institute of Sport - National Research Institute, Poland
Glucose Metabolism, High Altitude
High Altitude and Exogenous Carbohydrate Oxidation
Recent studies have reported that oxidation of exogenous carbohydrate is reduced under acute hypobaric hypoxic (high altitude; HA) conditions compared to normoxia (sea level; SL) in native lowlanders.
- Trial name
- NCT03851744
- Testing
- Sea Level, High Altitude
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Acute Mountain Sickness
HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase
Prospective cohort study investigating the menstrual cycle phase (MCP)-dependent incidence of acute mountain sickness (AMS) in women travelling to 3600 m.
- Trial name
- NCT06499714
- Testing
- Exposure to 3600 m
- Where
- Kyrgyzstan
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Acute Mountain Sickness
Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages
This double blind randomized trial will compare acetazolamide taken the morning of ascent to acetazolamide taken the evening prior to ascent for the prevention of acute mountain sickness (AMS).
- Trial name
- SEAWARD (NCT03424226)
- Testing
- Acetazolamide
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hypoxia, Altitude, Blood Flow Restriction
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
One approach to significantly reducing resistance training intensity while maintaining effectiveness in muscle mass and strength development involves conducting training sessions under hypoxic conditions.
- Conditions
- Hypoxia, Altitude, Blood Flow Restriction, Resistance Training
- Trial name
- NCT06171841
- Testing
- low-intensity resistance training, high-intensity resistance training, low-intensity resistance training combined with blood flow restriction
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Jerzy Kukuczka Academy of Physical Education in Katowice
Acute Mountain Sickness
Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy
This double blind randomized trial will compare ibuprofen to acetazolamide for the prevention of acute mountain sickness. These drugs have never been directly compared for efficacy.
- Trial name
- ASPIRATE (NCT03154645)
- Testing
- Ibuprofen, Acetazolamide
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Grant S Lipman
Severe High Altitude Pulmonary Edema, Severe High Altitude Cerebral Edema
Key Diagnostic & Therapeutic Technologies for Severe Acute High Altitude Disease (SAHAD): Integration and Application
This study aims to establish a key technical system for the diagnosis and treatment of severe acute mountain sickness based on real-world clinical data in Xizang, develop standardized diagnosis and treatment protocols and an…
- Trial name
- SAHAD (NCT07639931)
- Testing
- Multicenter study of HAPE：CPAP or BiPAP Group, Multicenter study of HAPE group：NO Group, Protocol for Proteomics and Peptidomics Study of HAPE：Case Group
- Where
- China
- Volunteers
- 3,035 people, healthy volunteers welcome
- Sponsor
- Tibet Autonomous Region People's Hospital
Acute Mountain Sickness, Blood Oxygen Saturation, Headache
Ibuprofen vs Acetaminophen for AMS Prevention
AMS (acute mountain sickness) affects those who ascend too high (>2000m) too fast. Acetazolamide is an effective drug for the prevention of AMS where proper acclimatization with gradual ascent may not be an option.
- Trial name
- NCT02244437
- Testing
- Ibuprofen, Acetaminophen
- Where
- Nepal
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Mountain Medicine Society of Nepal
High Altitude Effects, High Altitude Hypoxia
HighCycle Study: Acetazolamide, High Altitude and Plasma Volume
Each year, millions of people living at low altitude (< 1,000 m) travel to high altitude (≥ 2,500 m) for work, tourism, or sports activities.
- Conditions
- High Altitude Effects, High Altitude Hypoxia, Acute Mountain Sickness (AMS), Plasma Volume
- Trial name
- NCT07118462
- Testing
- Acetazolamide
- Where
- Kyrgyzstan
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Centre d'Expertise sur l'Altitude EXALT
Acute Mountain Sickness
Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort
Commercial aircraft passengers are exposed to atmospheric pressures ranging from the pressure found at ground level to that encountered in the external environment at 8,000 feet.
- Trial name
- NCT00326703
- Testing
- Hypobaric hypoxia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Boeing Company
Acute Mountain Sickness
Prevention of Acute Mountain Sickness by Intermittent Hypoxia
Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective in prevention of acute mountain sickness (AMS).
- Trial name
- NCT00559832
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Environmental Sleep Disorder, Cheyne-Stokes Respiration
Monitoring of the Cerebral Tissue Oxygenation and Perfusion in the Adapting Climber During Sleep in High Altitude
One of the major challenges in adapting to high altitudes is that with increasing altitude sleeping quality declines rapidly. Thus, the night sleep can only provide limited to none regeneration.
- Conditions
- Environmental Sleep Disorder, Cheyne-Stokes Respiration, Altitude Sickness
- Trial name
- PerOxySleep (NCT01465971)
- Where
- Germany
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Goethe University
Acute Mountain Sickness, High Altitude Pulmonary Edema
Hemodynamic Changes in Altitude Adaptation
We use a new technology (Nexfin from BMEYE-Inventive Hemodynamics) to monitor Cardiac Output, Blood Pressure, Fluid Responsiveness, Pulse Oximetry, Hemoglobin Concentration, Oxygen Delivery in Climbers during their process of…
- Conditions
- Acute Mountain Sickness, High Altitude Pulmonary Edema, High Altitude Cerebral Edema
- Trial name
- NCT01698619
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Goethe University