Clinical trials: Mouthwashes
Plaque, Dental, Antimicrobial
Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash
Moringa oleifera (MO) is an extraordinary nutritious vegetable tree with high medicinal value for its antibacterial properties. Formulation of various natural dental remedies from this plant and their testing for their…
- Conditions
- Plaque, Dental, Antimicrobial, Mouthwash, Cytotoxicity
- Trial name
- NCT04575948
- Testing
- Moringa Oleifera, Chlorhexidine mouthwash, Base formula
- Volunteers
- 90 people
- Sponsor
- Misr International University
Periodontal Index, Pain
Efficacy of Zinc L-Carnosine Mouth Rinse
A clinical trial to assess the effect of a Zinc-L-Carnosine-based mouth rinse on periodontal tissues and pain after scaling and root planing
- Trial name
- NCT04430998
- Testing
- Zinc L-Carnosine, Chlorhexidine, Water
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Milan
Nitric Oxide, Oral Microbiome
Nitrate Mouth Rinse and the Oral Microbiome
The study is aimed to determine if changes to the oral microbiome occur after the use of a nitrate rich mouth rinse. Participants with be asked to use either a controlled (water) mouthrinse once daily for 2 weeks while…
- Trial name
- NCT06588049
- Testing
- Beet Root, Water
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Dalhousie University
Head and Neck Neoplasms, Oral Mucositis (Ulcerative) Due to Radiation
Evaluating Chinese Medicine Oral Rinse for Irradiated Oral Mucositis in Head & Neck Cancer Patients
Approximately 60% and 90% of patients with head and neck (H\&N) cancers receiving standard radiotherapy (RT) and chemoradiotherapy (chemo-RT) will develop oral mucositis respectively.
- Conditions
- Head and Neck Neoplasms, Oral Mucositis (Ulcerative) Due to Radiation, Chinese Medicine Oral Rinse
- Trial name
- NCT05664906
- Testing
- Chinese Medicine Oral Rinse Formula-I (CMORF-I), Standard Care
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Oral Ulcer, Orthodontic Appliances, Fixed
Effectiveness of a Curcumin Mouthwash in Preventing Traumatic Ulcers in Patients With Fixed Orthodontic Appliances
The study is a randomized controlled trial. The participants will be equally allocated into 2 groups to compare clinical effectiveness of curcumin mouthwash in fixed orthodontic patients during the first month of treatment.
- Trial name
- NCT05147376
- Testing
- Curcumin mouthwash
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Postoperative Pain, Tonsillectomy
Ketamine Gargle for Pain After Pediatric Tonsillectomy
Post-tonsillectomy pain in children is a common and clinically significant problem that may lead to poor oral intake, dehydration, and delayed recovery.
- Conditions
- Postoperative Pain, Tonsillectomy, Adenotonsillectomy
- Trial name
- KET-TONSIL (NCT07558044)
- Testing
- Ketamine Hydrochloride in saline, Normal Saline (0.9% NaCl)
- Where
- Venezuela
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Caracas
Medication Associated Metallic Taste , Dysgeusia
Determination of the Safety and Effectiveness of an Oral Rinse in the Reduction of Medication Associated Metallic Taste
Patients taking chemotherapeutic agents often do not comply well with their dosing regiment since many of these medications cause a metallic taste in the mouth.
- Trial name
- NCT02992314
- Testing
- Metaqil™ Oral Rinse
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- You First Services
Dentin Hypersensitivity
Efficacy of a Potassium Nitrate Containing Herbal Mouthwash to a Potassium Oxalate Mouthwash in Dentinal Hypersensitivity
The goal of this clinical trial is to compare the efficacy of potassium nitrate containing herbal mouthwash to potassium oxalate mouthwash in management of dentinal hypersensitivity.
- Trial name
- NCT06627790
- Testing
- Mouthwash preparation
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Dentin Sensitivity
Clinical Study Investigating the Efficacy of a Mouthwash in Providing Long Term Relief From Dentinal Hypersensitivity
The aim of this study is to investigate the longitudinal efficacy of a potassium nitrate mouthwash formulation when used as an adjunct to brushing with a standard fluoride dentifrice for the relief of dentinal hypersensitivity…
- Trial name
- NCT02226562
- Testing
- Potassium nitrate and sodium fluoride, Standard fluoride dentifrice
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingivitis, Investigation of Biological Markers of Inflammation
Efficacy of Iocide Oral Rinse Against Gingival Inflammation
The purpose of this study is to explore the efficacy of Iocide oral rinse in a human clinical trial of gingivitis. Iocide oral rinse will be evaluated against a placebo rinse.
- Trial name
- NCT01782170
- Testing
- Iocide Oral Rinse
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Biomedical Development Corporation
Plaque, Gingivitis
Determination of the Safety and Efficacy of a Novel Oral Rinse on Oral Health
Since over 50% of the US population have gingivitis, mouthrinses serve as a valuable adjunct to brushing and flossing. The primary objective is to determine the effectiveness of the oral rinse in reducing plaque and gingivitis…
- Trial name
- NCT04197427
- Testing
- Experimental Oral Rinse
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- You First Services
hsCRP
Association Between Grade(B/C)of Stage III and IV Periodontitis and High Sensitivity C Reactive Protein Level in Serum and Oral Rinse Sample
According to 2017 World Workshop of Periodontology , the level of high sensitivity C reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at…
- Trial name
- NCT06997770
- Where
- India
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Periodontal Disease
Efficacy of Chlorhexidine and Morus Nigra Mouthwashes After Periodontal Treatment
This study aims to evaluate and compare the clinical, biochemical, and microbiological effects of chlorhexidine and Morus nigra (blackberry) mouthwashes used as an adjunct to non-surgical periodontal treatment (scaling and root…
- Trial name
- NCT07540624
- Testing
- 0.12% Chlorhexidine Gluconate Mouthwash, 5% Morus Nigra Mouthwash, Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Inonu University
Oral Malodor
Four-Week Oral Malodor and Clinical Safety for a Concentrated Cosmetic Mouthwash
The objective of this study is to evaluate the safety of the concentrated mouthwash prototypes, and to evaluate the efficacy of the concentrated mouthwash prototypes in the control of oral malodor compared to a comparator…
- Trial name
- NCT06479096
- Testing
- Brush / Espresso Mild Prototype, Brush / Espresso Intense Prototype, Brush / Fresh Breath Oral Rinse
- Where
- United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Wound Heal, Oral Microbiome
Effect of Mouthwashes on Oral Wound Healing and Microbiome
The purpose of this clinical research study is to investigate if mouthwashes to be tested can affect oral mucosal wound healing and change the oral microbiome (bacteria colonization) or expression of selected biomarkers.
- Trial name
- NCT05270382
- Testing
- cetylpyridinium chloride
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Chlorhexidine, Ventilator Associated Pneumonia
Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher…
- Trial name
- NCT03442023
- Testing
- Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12%
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Universidad de Guanajuato
Oral Mucositis
Gelclair at Conditioning or After Oral Mucositis Diagnosed vs. Magic Mouth Wash in Stem Cell Transplant Recipients
Patients receiving high-dose chemotherapy/conditioning prior to stem cell transplantation (SCT) are at high risk for developing painful lesions in the oral cavity, known as oral mucositis (OM).
- Trial name
- NCT03490396
- Testing
- Gelclair, First® Mouthwash BLM
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- Midatech Pharma US Inc.
Covid19
[COVID-19] Reduction of Sars-CoV-2 Oral Viral Load With Prophylactic Mouth Rinse
The purpose of this study is to test the effectiveness of prophylactic mouth rinses in reducing the amount of viruses, specifically SARS-CoV-2 in the oral cavity.
- Trial name
- NCT04719208
- Testing
- Water (E) Mouth rinse with the solution provided, Chlorhexidine gluconate (A) Mouth rinse with the solution provided, Hydrogen peroxide (B) Mouth rinse with the solution provided
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Oral Mucositis
A Study to Evaluate the Efficacy of MuGard for the Amelioration of Oral Mucositis in Head and Neck Cancer Patients
This study is a randomized, double-blind, sham-controlled, two-arm study conducted in subjects receiving chemoradiation therapy for the treatment of head and neck cancer to assess the efficacy of MuGard.
- Trial name
- MuGard (NCT01283906)
- Testing
- MuGard, Control Rinse
- Where
- 18 sites in United States
- Volunteers
- 120 people
- Sponsor
- Access Pharmaceuticals, Inc.
Oral Chronic Graft-versus-host Disease
Topical Dexamethasone and Tacrolimus for the Treatment of Oral Chronic Graft-Versus-Host Disease
The purpose of this research study is to determine the effectiveness of topical steroid therapy (with a drug called dexamethasone) and topical tacrolimus therapy for the treatment of oral chronic Graft-Versus-Host Disease (cGVHD)
- Trial name
- NCT00686855
- Testing
- Tacrolimus, Dexamethasone
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Brigham and Women's Hospital