Clinical trials: Movement; Disorder, Treatment-Induced
Pediatric Hemiparesis
Brain Stimulation and Hand Training in Children With Hemiparesis
Hemiparetic cerebral palsy influences motor function in children during development and throughout their lifetime. The deficits one sees are the result both of the congenitally induced brain lesion and the subsequent plasticity…
- Trial name
- NCT02250092
- Testing
- Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Minnesota
Hemiplegia, Cerebral Palsy
Infant Modified Constraint Induced Movement Therapy Paired With Neuromuscular Electrical Stimulation: a Case Series
This study will compare the motor outcomes for five infants with asymmetrical hand function (AHF) who will receive two, three week episodes of standard care separated by a three week episode of mCIMT paired with Neuromuscular…
- Conditions
- Hemiplegia, Cerebral Palsy, Unilateral Cerebral Palsy
- Trial name
- NCT05134272
- Testing
- Neuromuscular electrical stimulation, Modified constraint induced movement therapy, Standard care for infant with asymmetrical hand function
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kathy Grinde
Cerebral Palsy, Hemiplegic Cerebral Palsy
Implementation of Therapy Together
The goal of this clinical trial is to learn about the implementation of Therapy Together, a pediatric constraint-induced movement therapy program in young children with unilateral cerebral palsy.
- Trial name
- NCT06040619
- Testing
- Therapy Together, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Texas Scottish Rite Hospital for Children
Cerebral Palsy
Integrated Management Enhances Functional Gains in Children With Cerebral Palsy Treated by BoNT-A
Evidence from literature support the use of Botulinum toxin A (BoNT-A) for upper limb spasticity management in children with cerebral palsy (CP).
- Trial name
- NCT03302871
- Testing
- Botulinum toxin type A, transcranial direct current stimulation, hybrid training model of CIMT and BIT
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kocaeli University
Stroke
Encouragement-induced Movement Therapy in Daily Life
Stroke places a major burden on health care and society. It often leads to a hemiparesis. Intensive stroke rehabilitation speeds up recovery.
- Trial name
- ISEAR (NCT03294187)
- Testing
- Wrist-worn wearables
- Where
- 3 sites in Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Zurich
Psychotherapy, Substance Use Disorders
Eye Movement Desensitization and Reprocessing (EMDR) as a Treatment of Substance Use Disorders
The purpose of this clinical study is to examine the established, therapeutic EMDR intervention for patients with substance use disorders (SUD).
- Trial name
- NCT03114423
- Testing
- EMDR-Therapy
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Center of Integrative Addiction Research, Austria
Parkinson's Disease, Levodopa Induced Dyskinesias (LID)
Efficacy and Safety of Amantadine Hydrochloride (HCl) ER Tablets to Treat Parkinson's Disease Patients With LID.
This study was terminated early due to slow enrollment with 87 of 162 planned subjects enrolled. The purpose of this multi-center, randomized, double-blind, parallel-group, 16 week study is to compare the efficacy and safety of…
- Trial name
- ALLAY-LID-I (NCT02153645)
- Testing
- 240mg Amantadine HCl ER tablets, 320mg Amantadine HCl ER tablets
- Where
- 56 sites in United States, Canada and 3 more
- Volunteers
- 87 people
- Sponsor
- Adamas Pharmaceuticals, Inc.
Cerebral Palsy, Hemiplegia
Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy
A randomized control trial of bimanual training. The protocols have been developed at Columbia University to be child friendly and draws upon our experience since 1997 with constraint-induced movement therapy in children with…
- Conditions
- Cerebral Palsy, Hemiplegia, Children, Pediatric
- Trial name
- NCT00305006
- Testing
- Constraint-Induced Movement Therapy (CIMT), Hand-Arm Bimanual Intensive Therapy (HABIT)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Teachers College, Columbia University
Stroke
tDCS Combined With Constraint Induced Movement Therapy and Role of GABA Activity in Stroke Recovery
The aim of this study is to determine whether noninvasive brain stimulation in form of active transcranial direct current stimulation (tDCS) combined with constraint induced movement therapy (CIMT) offers an additional benefit as…
- Trial name
- NCT01983319
- Testing
- active anodal transcranial Direct Current Stimulation (tDCS), Constraint Induced Movement Therapy (CIMT)
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Parkinson Disease
Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)
Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine.
- Trial name
- NCT05509842
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
Stroke
Comparing Two Therapies to Improve Arm Function After Stroke
This clinical trial aims to compare the effects of coupling rehabilitation and constraint-induced movement therapy (CIMT) on improving arm function, hand skills, and daily activity performance in people who have upper limb…
- Trial name
- CR vs CIMT (NCT07093983)
- Testing
- Constraint-Induced Movement Therapy (CIMT), Coupling Rehabilitation
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- University of Lahore
Parkinson Disease
Lenrispodun as Adjunctive Therapy in the Treatment of Patients With Motor Fluctuations Due to Parkinson's Disease
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a diagnosis of Parkinson's Disease consistent with the UK Parkinson's Disease Society (UKPDS) Brain Bank…
- Trial name
- NCT05766813
- Testing
- Lenrispodun
- Where
- 35 sites in United States
- Volunteers
- 79 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Isquemic Stroke, Upper Limb Weakness Due to Central Neurologic Injury
Effectiveness of m-CIMT of the Upper Limb in Acute Post-stroke Patients. (m-CIMT, Modified Constraint-induced Movement Therapy)
m-CIMT therapy is the restriction of the unaffected upper extremity in conjunction with an upper extremity specific exercise protocol to improve the functionality and use of the affected upper extremity.
- Trial name
- m-CIMT (NCT07233161)
- Testing
- m-CIMT
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Clinic of Barcelona
Tardive Dyskinesia
Melatonin Treatment for Tardive Dyskinesia in Schizophrenia
This is a double-blind, randomized, placebo-controlled trial of melatonin as an add-on therapy to antipsychotics will be performed to examine the effects of melatonin on tardive dyskinesia symptoms and cognitive deficits in 120…
- Trial name
- NCT01391390
- Testing
- Melatonin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Beijing HuiLongGuan Hospital
Hemiplegia, Brain Tumor
Constraint-Induced Movement Therapy in a Pediatric Oncology Population
Hemiplegia (weakness or poor muscle function on one side of the body) is a neurological impairment which can occur in children as a result of a brain tumor or related treatment.
- Trial name
- SJCIT (NCT01447810)
- Testing
- Focused rigidity bi-valve long arm cast
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- St. Jude Children's Research Hospital
Tardive Dyskinesia
Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.
The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
- Trial name
- NCT02840760
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Dyskinesia, Drug-Induced, Parkinson Disease
Safinamide for Levodopa-induced Dyskinesia (PD-LID)
This will be a prospective, multi-center, randomized, double-blind, parallel group, placebo-controlled study, in participants with PD who are on a stable regimen of dopaminergic medication and have at least mild levodopa-induced…
- Trial name
- NCT03987750
- Testing
- Safinamide Methanesulfonate 150mg, Safinamide Methanesulfonate 100mg
- Sponsor
- Zambon SpA
Stroke
Comparison of Mirror Therapy and Modified Constrain Induced Movement Therapy on Risk of Fall, Balance and Gait in Stroke
There will be a difference between modified constraint induced movement therapy and Mirror Therapy on lower limb for risk of fall, balance and gait in stroke patients.
- Trial name
- NCT05985603
- Testing
- CIMT Group, Mirror Therapy group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Parkinson's Disease
Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease
A phase II double blind trial to evaluate the effects of the AMPA, glutamte antagonist, topiramate on levodopa-induced dyskinesia in Parkinson's disease
- Trial name
- NCT00296959
- Testing
- topiramate (drug)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Stroke
Modified Constrained - Induced Movement Therapy Compared to Intensive Bimanual Training
The purpose of the study is to evaluate the benefit of two different treatment approaches for the hemiplegic arm, modified Constraint-Induced Movement Therapy and task-related bimanual training.
- Trial name
- NCT00851123
- Testing
- Modified Constraint-Induced Movement therapy, Task-specific bimanual training
- Volunteers
- 30 people
- Sponsor
- University of Bergen