Clinical trials: Movement Abnormalities
Parkinson Disease, Fatigue
Lifestyle and Non-motor Symptom Management in Parkinson's Disease
Parkinson's Disease (PD) has generally been thought of as a movement disorder however other health-related symptoms, known as non-motor symptoms, are also very common.
- Trial name
- NCT04837976
- Testing
- Semi-structured interviews and a consensus workshops using nominal group techniques.
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Essential Tremor, Cervical Dystonia
Neurophysiologic Study of Patient With Essential Tremor and Dystonic Tremor
Background: Essential tremor is when a person has tremor, but no other neurological symptoms. Dystonic tremor is when a person also has dystonia. Dystonia is a condition in which muscle contraction causes changes in posture.
- Conditions
- Essential Tremor, Cervical Dystonia, Focal Dystonia
- Trial name
- NCT03041714
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Parkinsonian Syndrome
A Study of the Sense of Smell in Relatives of Parkinson's Disease Patients
In this study, individuals complete and return a mail survey, specifically a 40 item scratch and sniff smell test.
- Trial name
- NCT00096876
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson Disease
Virtual-reality for Upper Limb Rehabilitation in People With Parkinson's Disease
The aim of this study is to assess the effect of 8-week physiotherapy training using immersive virtual reality (VR-training) compared to a physiotherapy training performed in a real setting (RS-training) on handwriting and touch…
- Trial name
- NCT04876352
- Testing
- Upper limb/handwriting exercises in an immersive virtual reality setting (VR-training), Upper limb/handwriting exercises in a real setting (RS-training), No intervention
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Prof. Massimo Filippi
Parkinson's Disease
Pharmacokinetic-Pharmacodynamic Interaction Between Four Different Single Doses of BIA 3-202 and a Single Dose of Levodopa/Benserazide (100/25 mg)
The purpose of this study is to investigate the tolerability, pharmacokinetic profile of BIA 3-202 and its metabolites, and the pharmacokinetic and pharmacodynamic interaction between 4 different single doses of BIA 3-202 (50 mg…
- Trial name
- NCT02763852
- Testing
- BIA 3-202, Madopar® 125
- Where
- Portugal
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease(PD)
Gait Initiation Difficulty and Anticipatory Postural Adjustment (APA) Impairment in People With PD - Evaluation and Training
Gait initiation (GI) difficulty is common in people with Parkinson's disease (PD). Studies showed that the GI difficulty was related to impaired anticipatory postural adjustments (APA).
- Trial name
- NCT02656355
- Testing
- Weight shift training and APA feedback, Weight shift training without APA feedback
- Where
- Taiwan
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Alzheimer Disease, Parkinson Disease
Memory for Action in Neurological Patients
Memory for action is especially important in everyday life although current literature is not very abundant. The enactment effect (i.e.
- Trial name
- EMBODIMENT (NCT02844855)
- Testing
- Cognitive tests
- Where
- 2 sites in France
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Huntington Disease
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
The goal of this observational study is to learn about the usefulness of a test of social functioning in persons with Huntington disease.
- Trial name
- NCT07253038
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Parkinson Disease
Non-invasive Detection of Volatile Metabolites in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Currently, a diagnostic test for early PD does not exist.
- Trial name
- PANORAMA (NCT06453226)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Parkinson's Disease (PD)
The Effect of BIA 9-1067 at Steady-state on the Levodopa Pharmacokinetics
The purpose of this study is to determine the effect of repeated dosing of once-daily 25, 50 and 75 mg opicapone (OPC, development code BIA 9-1067) on the levodopa pharmacokinetics (PK), in comparison to placebo and 200 mg…
- Trial name
- NCT02170376
- Testing
- BIA 9-1067, Entacapone, Levodopa/carbidopa
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Progressive Supranuclear Palsy
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
This study is designed to learn more about overall tau burden in the brain of patients with Progressive Supranuclear Palsy (PSP).
- Trial name
- NCT02605785
- Testing
- F-18 AV 1451
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease, Gaucher's Disease
Intravenous N-acetylcysteine for the Treatment of Gaucher's Disease and Parkinson's Disease
The investigators are interested in determining if the investigators are able to detect changes in brain chemistry using Magnetic Resonance Spectroscopy (MRS) in individuals with Parkinson's disease (PD), those with Gaucher's…
- Trial name
- NCT01427517
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease, Parkinsonian Disorders
Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease
This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsules（BIFICO） on motor symptoms and constipation and sleep in…
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Basal Ganglia Diseases, Brain Diseases
- Trial name
- NCT04871464
- Testing
- Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules
- Where
- 10 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Traumatic Brain Injury, Stroke
Remote Neuropsychological Assessment of Patients With Neurological Disorders and Injuries
For the last decades, many aspects of human life have been altered by digital technology. For health care, this have opened a possibility for patients who have difficulties travelling a long distance to a hospital to meet with…
- Conditions
- Traumatic Brain Injury, Stroke, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT05819008
- Testing
- Neuropsychological Assessment
- Where
- Sweden
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Umeå University
Parkinson's Disease, Parkinsonism
Parkinson's Families Project
One person in every 500 has Parkinson's and around 127,000 people are living with the condition in the UK. The aim of the study is to identify new genes that predispose or cause Parkinson's Disease or Parkinsonism.
- Trial name
- PFP (NCT02760108)
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease
The Differential Diagnosis and Prognosis of Idiopathic and Atypical Parkinson Disease by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04472325
- Where
- Taiwan
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson Disease
Self-motion Perception in Parkinson's Disease
Parkinson's Disease as well as being a disorder of motor function also causes a wide range of non-motor disturbances many of which are involved in the prodromal stage prior to the onset of motor symptoms.
- Trial name
- SMP_PD (NCT03137238)
- Testing
- Investigation of self-perception in Parkinson's disease
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Huntington Disease, Alzheimer Disease
A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan
This drug-drug interaction study is being conducted to evaluate the potential effect of Dimebon on the pharmacokinetics on dextromethorphan, a probe substrate of the cytochrome P450 2D6 (CYP2D6) enzyme, after multiple dose…
- Trial name
- NCT00788047
- Testing
- Dextromethorphan, Dimebon + Dextromethorphan
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
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