Clinical trials: Movement Abnormalities
Parkinson Disease
Merging Yoga and Occupational Therapy for Parkinson Disease: Phase 2
The full program is focused on identifying and reducing risk factors surrounding falls. Based on previous research, we believe that occupational therapy group classes and adaptive yoga are an ideal pairing to reduce fall risk.
- Trial name
- MY-OT for PD (NCT03578653)
- Testing
- Merging Yoga and Occupational Therapy for Parkinson disease
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Idiopathic Parkinson Disease
A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in PD Patients
This is a prospective study in a cohort of about 500 patients with Idiopathic Parkinson's disease, examined routinely in the neurological outpatient clinic.
- Trial name
- NCT05437003
- Testing
- NeuraLight software-based platform
- Where
- Israel
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- NeuraLight
Caregiver Stress, Dementia
A Study of Caregiver Connections Via Technology in Dementia
This research is being done to develop a unique matching process for caregivers of persons living with dementia, such as Alzheimer's disease, Lewy body dementia, frontotemporal degeneration, or other dementia syndromes.
- Conditions
- Caregiver Stress, Dementia, Alzheimer Disease, Lewy Body Dementia
- Trial name
- NCT05779839
- Testing
- Algorithm, Random Match
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease, Accidental Fall
Development and Evaluation of a Guide to Help People With Parkinson's and Their Caregivers to Self-manage Falling
This study will investigate whether it is possible, through the development and evaluation of a self-management guide, to improve health related quality of life and concern of falling in people with Parkinson's disease who fall…
- Trial name
- NCT03111472
- Testing
- Self-management guide for people with Parkinson's who fall and their informal caregivers
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Wilson's Disease, Myocardial Dysfunction
Subclinical Myocardial Dysfunction in Children With Wilson's Disease
Wilson's disease (WD) is one of the most common metabolic liver diseases in older children. The most frequent clinical presentation is liver disease. However, Wilson's disease (WD) is a multisystem disorder.
- Conditions
- Wilson's Disease, Myocardial Dysfunction, Children, Wilson Disease
- Trial name
- NCT07765472
- Testing
- Echocardiography, Electrocardiography, N-terminal pro b- type natriuretic peptide
- Where
- 2 sites in Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hebatullah Fawzy
Movement Disorders, Aging
Effects of Exercise Poles on Older Adults During Exercise Walking
This study uses a patented type of exercise poles, developed to assist runners rehabilitating from lower body injuries. These poles may offer older adults improved stability, reduced fear of falling, and lessened lower body pain…
- Trial name
- NCT00037167
- Testing
- Exercise poles
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Tourette's Syndrome, Chronic Motor Tic Disorder
Brain Activation in Vocal and Motor Tics
This study will investigate the brain areas that are activated by vocal and motor tics in patients with Tourette's syndrome and other tic disorders. Tics are involuntary repetitive movements similar to voluntary movements.
- Conditions
- Tourette's Syndrome, Chronic Motor Tic Disorder, Chronic Motor Vocal Disorder
- Trial name
- NCT00026000
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
ALTROPANE® SPECT Imaging in Patients With Parkinson Disease
After a screening evaluation including baseline clinical laboratory testing, a physical and neurological evaluation, subjects will be asked to undergo an injection of ALTROPANE® followed by up to 60 minutes of serial dynamic…
- Trial name
- NCT00397228
- Testing
- ALTROPANE®
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Molecular NeuroImaging
Huntington Disease
Study of Biomarkers That Predict the Evolution of Huntington's Disease
Huntington's disease (HD) is a rare, autosomal dominant, progressive neurodegenerative disorder typically becoming noticeable in middle age.
- Trial name
- BIOHD (NCT01412125)
- Testing
- Huntington patient evaluation, Healthy subject evaluation
- Where
- France
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson's Disease
Parkinson's Diseases Susceptibility Genes and Pesticides
Parkinson's disease (PD) occurrence is higher in rural than in urban populations of industrialized countries. Epidemiologic and human tissue studies suggest that pesticides may be responsible for causing dopaminergic cell death…
- Trial name
- NCT00044590
- Where
- United States
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Parkinson Disease
The Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
This study is a double-blinded randomized study examining the efficacy of the double-site (M1+SMA) repetitive transcranial magnetic stimulation on Freezing of Gait (FOG) in patients with Parkinson's disease.
- Trial name
- NCT06415682
- Testing
- SMA+M1 Transcranial Magnetic Stimulation, M1 Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
miRNAs Profiling in Parkinson's Disease
microRNAs (miRNAs) regulate fundamental cell processes. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological disorders.
- Trial name
- NCT03466723
- Testing
- biomarker identification in Parkinson disease
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Parkinson Disease
tACS Modulates Speech and Cognitive Impairments in People With PD by Targeting the Medial Frontal Cortex
This clinical trial aims to study whether transcranial alternating current stimulation (tACS) applied to the medial frontal cortex (MFC) can improve speech and cognitive function in people with Parkinson's disease (PD), and to…
- Trial name
- NCT07240272
- Testing
- 6Hz-tACS
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ke Dong, MD
Parkinson Disease, Idiopathic, Freezing of Gait
AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the Home
Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease increases the risk of falling. Despite being a common symptom, it is still difficult to evaluate freezing of gait quickly and accurately.
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Validation, Wearable Sensors
- Trial name
- AID-FOG (NCT07580612)
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Parkinson Disease
Prevention of Medical, Social, and Psychosocial Risks Following a Parkinson's Disease Diagnosis: A Pilot Study
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, with a prevalence expected to double by 2040.
- Trial name
- PRIMS-PARK (NCT07578272)
- Testing
- Patient questionnaires, Caregiver questionnaires
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Fragile X Syndrome, Angelman Syndrome
Parent and Infant Inter(X)Action Intervention (PIXI)
The objective is to develop and test, through an iterative process, an intervention to address and support the development of infants with a confirmed diagnosis of a neurogenetic disorder with associated developmental delays or…
- Conditions
- Fragile X Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Dup15Q Syndrome
- Trial name
- NCT03836300
- Testing
- Parent-Infant Inter(X)action Intervention (PIXI)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RTI International
Parkinson Disease, Dementia
Imaging Studies of Cognitive Impairment in Parkinson s Disease
Background: Parkinson's disease causes slow movements, stiffness, and tremor. It can get worse over time, and in some cases can lead to dementia.
- Trial name
- NCT01862744
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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