Clinical trials: Movement Abnormalities
Parkinson Disease
Effect of BIA 9-1067 on Cardiac Repolarization in Healthy Adult Men and Women
The purpose of this study is to evaluate the effect of BIA 9-1067 on the cardiac repolarization in adult healthy men and women volunteers.
- Trial name
- NCT01532115
- Testing
- BIA 9-1067, moxifloxacin
- Where
- France
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Huntington Disease
IMarkHD: in Vivo Longitudinal Imaging of HD Pathology
iMarkHD is an adaptive, longitudinal positron emission tomography (PET) and magnetic resonance (MR) imaging study in Huntington's disease (HD) that aims to assess abnormal molecular, functional, and structural changes in…
- Trial name
- NCT03434548
- Testing
- PET imaging, Multi-modal MRI imaging
- Where
- United Kingdom
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- King's College London
Tourette Syndrome
Washed Microbiota Transplantation for Tourette's Syndrome
This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).
- Trial name
- WMT (NCT03764748)
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Parkinson Disease
FoxBioNet: ECV (Extracellular Vesicle) 004
The goal of this study is to identify reliable markers of LRRK2 activity in human CSF.
- Trial name
- NCT04603326
- Testing
- Lumbar Puncture
- Where
- 4 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson's Disease
Study to Investigate the Ability of [11C]Donepezil PET to Image the Parasympathetic Nervous System
AIM: To validate the tracer [11C]donepezil for use in the parasympathetic nervous system. MATERIALS AND METHODS: The Investigators will include 7 healthy males aged 45-75 in our study.
- Trial name
- NCT01877538
- Testing
- [11C]donepezil PET
- Where
- Denmark
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Per Borghammer
Parkinson's Disease, Depression
Barriers to Mental Healthcare Utilization in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly. In most people, the illness is complicated by co-occurring psychiatric problems such as depression and anxiety.
- Conditions
- Parkinson's Disease, Depression, Anxiety
- Trial name
- NCT01167608
- Testing
- No Intervention. This is a cross-sectional survey study.
- Where
- United States
- Volunteers
- 883 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Follow up, Parkinson Disease
Two-year Follow-up to High-intensity Multi-component Agility Intervention That Improves Clinical and Motor Symptoms of Parkinson's Disease
Individualization of exercise is recommended but rarely performed in patients with Parkinson's disease (PD). Unusually High Intensity and Individual Sensor Motor with Visuomotor Mobility Trainer The clinical symptoms, mobility…
- Conditions
- Follow up, Parkinson Disease, Rehabilitation
- Trial name
- NCT03193489
- Testing
- Follow-up, Post-treatment control, Control Parkinson group
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Parkinson Disease
Self-controlled Practice on Motor Learning and Motivation in Parkinson's Disease
People with Parkinson's disease have been known to have low motivation and motor learning impairment, which might limit the effectiveness of neurorehabilitation, exacerbate motor performance and quality of life, and increase the…
- Trial name
- NCT07028515
- Where
- Taiwan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease
A Randomized, Double-blind, Placebo-controlled Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetics of JX2105 in Healthy Chinese Subjects
The purpose of the study is to evaluate the safety, tolerability after administration of single dose or multiple doses, and the pharmacokinetics (PK) of single and multiple doses of JX2105 in healthy study participants.
- Trial name
- NCT06537050
- Testing
- JX2105
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Zhejiang Jingxin Pharmaceutical Co., Ltd.
Parkinson's Disease, Parkinsonism
Parkinson's Families Project
One person in every 500 has Parkinson's and around 127,000 people are living with the condition in the UK. The aim of the study is to identify new genes that predispose or cause Parkinson's Disease or Parkinsonism.
- Trial name
- PFP (NCT02760108)
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Parkinson Disease, Multiple System Atrophy
Diagnostic and Prognostic Biomarkers in Parkinson Disease
The overall goal of PROBE is to evaluate the feasibility and potential utility of three markers (alpha-synuclein, transcriptomic profiles and olfactory function) to determine the risk or prognosis of PD.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- PROBE (NCT00653783)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Parkinson Study Group
Autonomic Failure, Pure Autonomic Failure
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia.
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Parkinson Disease, Multiple System Atrophy
- Trial name
- NCT04246437
- Testing
- [18F]FDOPA, Carbidopa 200mg oral dose, Entacapone 400mg oral dose
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Daniel Claassen
Healthy, Parkinson Disease
PET Study of the Nicotinic Receptors in Human
The purpose of this study is to quantify the brain distribution of the nicotinic receptors in human volunteers and their alterations in patients suffering from neurological diseases such as Parkinson and Alzheimer diseases and…
- Conditions
- Healthy, Parkinson Disease, Alzheimer Disease, Epilepsy
- Trial name
- NCT00543322
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Commissariat A L'energie Atomique
Parkinson Disease
Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes
Connect.Parkinson is a randomized comparative effectiveness study, comparing usual care enhanced with educational materials to usual care, educational materials, and the delivery of specialty care via telemedicine into patient's…
- Trial name
- NCT02038959
- Testing
- Virtual Visits
- Where
- 20 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Parkinson's Disease
An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease
This study is being conducted to assess the impact of folate and L-methylfolate on the progression of Parkinson's. The investigators are specifically looking for the effect of these nutritional supplements in Parkinson's patients…
- Trial name
- NCT00853879
- Testing
- Folic Acid, Vitamin B6, Vitamin B12, B6, B12, L-methylfolate
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Parkinson's Disease
Study on Bioequivalence of Pramipexole Dihydrochloride Sustained Release Tablets
The main purpose of In two kinds of fasting and postprandial Chinese healthy subjects with Boehringer represent Ingelheim company production of hydrochloric acid Pramipexole zyban (specification: 0.26 mg/piece, in Pramipexole…
- Trial name
- PLKS-BE (NCT04275492)
- Testing
- Praxol hydrochloride sustained release tablet Specification: 0.375mg/ tablet (in pramipexole hydrochloride), Pramipexole hydrochloride sustained-release tablet (Siforl®) Specification: 0.26mg/ tablet (in pramipexole)
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Hyposmia, Parkinson Disease
The Vietnamese Smell Identification Test in the Diagnosis of Parkinson's Disease
The goal of this observational study is to assess the value of the Vietnamese smell identification test (VSIT) in the diagnosis of Parkinson's disease, and compare it with the commonly used test in the world, Brisk smell…
- Trial name
- NCT05837637
- Testing
- The Vietnamese Smell Identification test (VSIT), the Brief Smell Identification test (BSIT)
- Where
- Vietnam
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Parkinson Disease
Non-drug Treatment Study in Parkinson's Disease Patients and Healthy Volunteers to Collect Biological Samples in Order to Assess ex Vivo the Activity of Candidate Therapies and Develop Novel Analytical Methods for Biomarkers
This is a non-drug study in patients with Parkinson's Disease (PD) and healthy volunteers to process and analyze their blood and optional cerebrospinal fluid (CSF) samples ex vivo, or outside of their body, to further develop…
- Trial name
- IRIS-CLE-LRRK2 (NCT05837130)
- Testing
- Blood sample collection and an optional cerebrospinal fluid (CSF) collection, Blood sample collection
- Where
- 4 sites in France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Servier
Alzheimer's Disease, Cortical Basal Syndrome
18F-PM-PBB3 PET Study in Tauopathy Including Alzheimer's Disease, Other Dementias and Normal Controls
This is an open-label study to evaluate the performance of a novel tau imaging ligand in up to 36 subjects (12 AD, 3 FTD, 3 PSP, 3 CBS, 3 VCI and 12 HV).
- Conditions
- Alzheimer's Disease, Cortical Basal Syndrome, Frontotemporal Dementia, Progressive Supranuclear Palsy
- Trial name
- NCT03625128
- Testing
- F-18
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
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