Clinical trials: Movement Abnormalities
Parkinson's Disease, Parkinsonism
Study of UB-312 in Healthy Participants and Parkinson's Disease Patients
This is a 44-week, randomized, placebo-controlled, double-blind, single-center, phase 1 clinical trial consisting of a dose-escalation Part A study in healthy participants, followed by a Part B in participants with Parkinson's…
- Trial name
- NCT04075318
- Testing
- UB-312
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- United Neuroscience Ltd.
Parkinson Disease
Single Ascending Doses of HER-096 in Healthy Subjects
This study evaluates the safety and tolerability of HER-096 in healthy volunteer subjects by comparing the effects of active study treatment HER-096 to placebo (0.9% physiological saline).
- Trial name
- NCT05915247
- Testing
- HER-096
- Where
- Finland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Herantis Pharma Plc.
Parkinson Disease
Vestibular and Cortical Contributions to Transitions in Freezing of Gait in Parkinson's Disease
Currently, there is a lack of comprehensive knowledge about the role of vestibulospinal drive and cortical activity during self-initiated movement transitions in older adults and people with PD (both with and without FOG).
- Trial name
- NCT06506058
- Testing
- EVS and EEG
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease, Parkinsonian Disorders
Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease
This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsules（BIFICO） on motor symptoms and constipation and sleep in…
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Basal Ganglia Diseases, Brain Diseases
- Trial name
- NCT04871464
- Testing
- Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules
- Where
- 10 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
SCI - Spinal Cord Injury, PD - Parkinson's Disease
Differential Assessment of Hypertonia
Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements.
- Trial name
- NCT06596187
- Testing
- Continuous passive motion device (CPM) of ankle - fast, Continuous passive motion device (CPM) of ankle - slow
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Parkinson's Disease
Single Ascending Dose Study of PRX002 in Healthy Subjects
This single ascending dose study is to determine safety, tolerability, pharmacokinetics and immunogenicity of PRX002 in approximately 40 healthy subjects.
- Trial name
- NCT02095171
- Testing
- PRX002
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Prothena Biosciences Limited
Parkinson Disease
Parkinson Disease Telerehabilitation Program (PDTR): a Home-motor Program. A Pilot Study.
Parkinson's disease (PD) leads to multifactorial disabilities with consequent social restrictions, especially in the COVID-19 era.
- Trial name
- NCT05762562
- Testing
- Telerehabilitation with open source platforms
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Parkinson's Disease With LRRK2 Mutation, Healthy Controls
Measure of Microglial Activation in the Brain of Parkinson Disease Patients With PET
There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in the neurodegenerative process of Parkinson's disease (PD).
- Conditions
- Parkinson's Disease With LRRK2 Mutation, Healthy Controls, Parkinson's Disease Without LRRK2 Mutation
- Trial name
- INFLAPARK (NCT02319382)
- Testing
- PET with the tracer 18F-DPA-714, PET with the tracer 11C-PE2I, MRI
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Movement Disorders
Compare the Effects of Agility and Cycling Exercise Training on Mobility and Balance in PD and Healthy Old Adults
The purpose of the study is to compare the effectiveness and specificity of agility and cycling exercise training on balance and mobility outcomes in PD and age and gender matched healthy controls.
- Conditions
- Healthy, Movement Disorders, Parkinson Disease, Condition
- Trial name
- NCT03427762
- Testing
- Rehabilitation
- Where
- Hungary
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Movement Disorders
Retrospective Study on MR Imaging of ET and PD Patients Subjected With MRgFUS Thalamotomy
The technological advance of magnetic resonance-guided focused ultrasound (MRgFUS) has once again brought lesion therapy back to the clinical frontline for the treatment of movement disorder.
- Trial name
- NCT04570046
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Tourette Syndrome
Atomoxetine in Patients With Tourette's Syndrome
The purpose of this pilot study is to evaluate the effects of Atomoxetine, a selective noradrenaline reuptake inhibitor, on impulsivity in patients with Tourette's syndrome.
- Trial name
- ATO-TS (NCT04354103)
- Testing
- Atomoxetine
- Where
- 3 sites in France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Dystonia, Focal Dystonia
Brain Changes in Blepharospasm
This study will examine the role of certain areas of the brain in blepharospasm, a type of dystonia (abnormality of movement and muscle tone) that causes unwanted or uncontrollable blinking or closing of the eyelids.
- Conditions
- Dystonia, Focal Dystonia, Cerebellar Disease
- Trial name
- NCT00487383
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tardive Dyskinesia
Repetitive Transcranial Magnetic Stimulation for the Treatment of the Tardive Dyskinesia.
The purpose of this study is to explore the therapeutic effect and mechanism of transcranial magnetic stimulation (rTMS) in the treatment of the tardive dyskinesia.
- Trial name
- NCT02840760
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Akathisia
Akathisia (Restless Legs Syndrome) in People With Schizophrenia and Mental Retardation
Akathisia is a movement disorder that is often a side effect of certain psychiatric drugs. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace.
- Trial name
- NCT00065286
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Tourette Syndrome, Habit Reversal Training
Extinction Learning in Adults With Tourette Syndrome
Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still…
- Conditions
- Tourette Syndrome, Habit Reversal Training, Tic Disorders, Tics
- Trial name
- NCT04498364
- Testing
- Habit Reversal Training
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Parkinson Disease
The Parkinson's Disease Case-Control Study
The Parkinson's Disease Case-Control Study is a study of healthy volunteers and patients with Parkinson's disease aged 50-75 years living in Hangzhou, China.
- Trial name
- NCT06848192
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Parkinson Disease, Multiple System Atrophy
A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With Synucleinopathies
This will be an observational study looking at clinical and biomarker characteristics in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Rapid Eye Movement Sleep Behavior Disorder (RBD), Normal Pressure…
- Conditions
- Parkinson Disease, Multiple System Atrophy, Rapid Eye Movement Sleep Behavior Disorder, Normal Pressure Hydrocephalus
- Trial name
- NCT04020198
- Testing
- Biomarker assay
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Alzheimer Disease, Parkinson Disease
The Assessment of the Diagnosis and Prognosis of Patients With Alzheimer Disease or Parkinson Disease With Cognitive Impairment by Using Diffusion MRI
The hypothesis is that the differential extent of microstructural damages in the affected brain regions can be specific to the disease of interest and could reflect the clinical severity.
- Trial name
- NCT04434898
- Where
- Taiwan
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson's Disease, Multiple System Atrophy
Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy
In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a…
- Trial name
- NCT03721887
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Parkinson Disease
Intelligibility Assessment for Parkinson's Disease
The investigators aim at testing the efficacy of an app to measure sentence intelligibility in noise in speakers with Parkinson's disease and in healthy controls.
- Trial name
- NCT04829006
- Testing
- Understand Me For Life
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Long Island University
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