Clinical trials: Movement Abnormalities
Movement Disorders (Incl Parkinsonism), Tremor Familial Essential, 1
MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder.
This proposal is focused on developing a reliable, valid, and reproducible imaging techniques and statistical methodology for segregation of various forms of Parkinsonism from healthy adults without Parkinsonism.
- Conditions
- Movement Disorders (Incl Parkinsonism), Tremor Familial Essential, 1, REM Sleep Behavior Disorder
- Trial name
- NCT01547481
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
The Effects of Augmented and Virtual Reality Gait Training on Patients With Parkinson's Disease
In Parkinson's Disease (PD) rehabilitation, the treadmill is used both in aerobic training and in gait training, as it provides more walking distance and can include body weight supported systems.
- Trial name
- NCT05439967
- Testing
- Augmented and Virtual Reality Gait and balanceTraining, Conventional Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Parkinson Disease, Exercise
Effectiveness of Video-Based Upper Extremity Exercise Program in Parkinson's Disease
Over the past decade, virtual reality (VR) has been widely recognized as a therapeutic tool that enables neurological patients to interact with simulated environments through multiple sensory channels.
- Conditions
- Parkinson Disease, Exercise, Exergame, Therapy
- Trial name
- NCT06807411
- Testing
- Conventional exercise, Video game based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Medipol University Hospital
Parkinson s Disease
Rhythmic Auditory Stimulaton Using Personalized Music Therapy in Parkinson's Disease
Parkinson's disease (PD) is a progressive neurodegenerative disorder commonly associated with gait disturbances, balance impairments, and freezing of gait, which significantly increase the risk of falls and reduce functional…
- Trial name
- RASP-PD (NCT07378722)
- Testing
- conventional physical therapy, Rhythmic Auditory Stimulation (RAS)
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Rumesa Butt
Parkinson Disease
DBS and Respiration
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease.
- Trial name
- NCT04058457
- Testing
- DBS
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Parkinson Disease, Deep Brain Stimulation
Effect of Physical Activity on the Course of Parkinson's Disease in Patients With Bilateral DBS-STN Stimulation.
Parkinson's disease is a common, progressive neurodegenerative disorder. The degeneration of dopaminergic neurons is associated with characteristic clinical symptoms such as tremor, rigidity, slowness of movement (bradykinesia)…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, PD - Parkinson's Disease, PD
- Trial name
- EPA-DBS (NCT07838636)
- Testing
- Physiotherapy, Education about physiotherapy
- Where
- Poland
- Volunteers
- 102 people
- Sponsor
- Medical University of Warsaw
Parkinson's Disease
Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation
Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms.
- Trial name
- NCT00169364
- Testing
- positron emission tomography
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Parkinson's Disease
Non-interventional, Retrospective, Multi-center Study to Evaluate Non-motor Symptoms in Advanced Parkinson Disease (PD) Patients Already Treated With Rotigotine
This is an observational, non-interventional and retrospective study in patients with advanced PD who have been treated with Rotigotine (Neupro®) as prescribed by physicians according to usual clinical practice in Spain.
- Trial name
- RETO-PD (NCT01504529)
- Where
- 59 sites in Spain
- Volunteers
- 391 people
- Sponsor
- UCB Pharma
Parkinson Disease
Pramipexole Conversion to Ropinirole Controlled Release (CR)
A conversion study of Mirapex (pramipexole) to Requip (ropinirole) controlled release (CR) in patients with Parkinson's disease to determine the appropriate conversion ratio and side effects related to the drug.
- Trial name
- NCT00275275
- Testing
- Requip PR, Mirapex
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Rajesh Pahwa, MD
REM Behavior Disorder, Parkinsonism
Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism
Parkinson's disease (PD) is the second most common neurodegenerative disorder of the elderly that affects a million patients in US. Sleep dysfunction impacts up to 90% of PD patients.
- Trial name
- NCT00745030
- Testing
- Rozerem
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Parkinson Disease
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers
The goals of this study are 1. To compare the functional effects of the LRRK2 G2385R variant among carriers with and without Parkinson's disease (PD) and non-carriers with and without PD 2.
- Trial name
- NCT04349865
- Where
- China
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Depression, Parkinson's Disease
Telephone-Based Counseling for Depression in Parkinson's Disease
There is a critical need for treatments that address depression and barriers to mental health care in Parkinson's disease (PD). This randomized-controlled trial will evaluate a 10-session telephone-guided cognitive behavioral…
- Trial name
- TH-CBT (NCT02505737)
- Testing
- TH-CBT, Enhanced Usual Care
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Rutgers, The State University of New Jersey
Parkinson Disease
Quantitative Imaging of Brain Glymphatic Function in Humans
Recent immunological and physiological studies have provided evidence in support of a central nervous system (CNS) lymphatic drainage system in vertebrate animals, and preliminary evidence has suggested that a similar system…
- Trial name
- NCT04768101
- Testing
- [11C]-PIB
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Alzheimer's Disease, Parkinson's Disease
Social Cognition and Personality Changes in Alzheimer's & Parkinson's Disease & Frontotemporal Lobar Degeneration
The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.
- Conditions
- Alzheimer's Disease, Parkinson's Disease, Frontotemporal Lobar Degeneration
- Trial name
- NCT02964611
- Testing
- Observational Study
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Parkinson's Disease
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD).
- Trial name
- NCT05557864
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Parkinson's Disease
Pharmacokinetics,Pharmacodynamics,Efficacy and Safety of HRG2010 in Parkinson's Disease Patients With Motor Fluctuations
The study is a multicenter, randomized, open-label, active-controlled, Phase II clinical study. The aim of this trial is to evaluated the pharmacokinetics, pharmacodynamics,efficacy and assessed the safety of HRG2010 compared…
- Trial name
- NCT06614153
- Testing
- HRG2010(I), HRG2010(II), Sustained-release Carbidopa/Levodopa
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Parkinson's Disease
Rasagiline in Advanced Parkinson's Disease Patients With Motor Fluctuations Treated With Levodopa/Carbidopa Therapy.
Study to look at the effectiveness, tolerability and safety of two doses of Rasagiline (0.5 mg and 1mg) in advanced Parkinson's Disease (PD) Patients who have been treated with Levodopa/Carbidopa therapy.
- Trial name
- NCT00203177
- Testing
- rasagiline mesylate, rasagiline mesylate 1.0 mg
- Where
- 8 sites in United States, Canada
- Volunteers
- 254 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Parkinson's Disease
Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients
Use lay language. Many decisions involve the possibility of gaining or losing relative to the status quo. The loss aversion behaviour is a cognitive concept explaining that people are more sensitive to the possibility of losing…
- Trial name
- NCT01780467
- Testing
- Role of dopamine
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson's Disease, Multiple System Atrophy
Increased Gut Permeability to Lipopolysaccharides (LPS) in Parkinson's Disease
The gut may be a portal of entry for agents that cause or contribute to the causes of Parkinson's disease (PD). The investigators are studying changes in the normal population of gut flora and in intestinal permeability and their…
- Trial name
- NCT01155492
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Parkinson's Disease
Exercise for People With Parkinson's Disease
This randomized, controlled exercise intervention with three groups compares two exercise approaches to standard of care. Supervised interventions are administered for four months, with emphasis on patients adopting exercise…
- Trial name
- NCT01257945
- Testing
- Aerobic Exercise, Flexibility and Function exercise program, Home exercise program
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Colorado, Denver
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