Clinical trials: Movement Abnormalities
Parkinson's Disease
Varenicline Treatment for Excessive Daytime Sleepiness in Parkinson's Disease
The effect of varenicline, an alpha4beta2 nicotinic receptor partial agonist on excessive daytime sleepiness in Parkinson's disease will be studied in a randomized, double blind, placebo-controlled clinical trial with a…
- Trial name
- VESPA (NCT02473562)
- Testing
- Varenicline
- Where
- 2 sites in Netherlands
- Volunteers
- 22 people
- Sponsor
- Amsterdam UMC, location VUmc
TMS Protocols in the Treatment of PD
Standardization and Optimization of TMS Protocols for the Treatment of PD With Depression or Cognitive Impairment
The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in Parkinson's disease patients with depression or cognitive impairment.
- Trial name
- NCT03552861
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- 10 sites in China
- Volunteers
- 252 people
- Sponsor
- Guangdong Provincial People's Hospital
Parkinson's Disease
Interleaving Stimulation Improves Dyskinesia in Parkinson's Disease
This study is designed as a prospective, randomized, double-blind, controlled study to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to post-operation dyskinesia…
- Trial name
- NCT06239454
- Testing
- interleaving stimulation, empirical stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Parkinson's Disease, Multiple System Atrophy
Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy
Patients with Parkinson's Disease or Multiple System Atrophy (MSA), and symptoms of orthostatic hypotension, are eligible for the study.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Orthostatic Hypotension
- Trial name
- NCT00103597
- Testing
- Fludrocortisone, Domperidone, Conservative Measures for Orthostatic Hypotension
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Royal Brisbane and Women's Hospital
Stroke, Parkinson Disease
Exploratory Study About the Implementation of Technology in the Rehabilitation
This qualitative study aims to identify the needs and recommendations of both patients and healthcare professionals in terms of rehabilitation technology, more specific three pre-defined user scenarios.
- Conditions
- Stroke, Parkinson Disease, Covid19, Neglect, Hemispatial
- Trial name
- NCT04833088
- Testing
- Focus group discussions
- Where
- Belgium
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Tourette Syndrome
Dopaminergic Effects on Cortical Function in Tourette's (Levodopa Protocol)
Dr. Kevin J. Black at Washington University is conducting a study to learn whether we can use MRI scans to test dopamine function in the brain and to determine whether the brain performs memory tasks differently in Tourette…
- Trial name
- TSfMRI (NCT00634556)
- Testing
- levodopa solution 2mg/ml for i.v. use
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Tremor, Action Tremor
Deep Brain Stimulation (DBS) for the Suppression of Tremor
The purpose of the proposed study is to demonstrate the safety and efficacy of the ANS Totally Implantable Deep Brain Stimulation System in the VIM nucleus of the thalamus implanted for the treatment of tremor due to essential…
- Conditions
- Tremor, Action Tremor, Essential Tremor, Tremor, Limb
- Trial name
- NCT02087046
- Testing
- ANS Totally Implantable Deep Brain Stimulation System
- Where
- 12 sites in United States
- Volunteers
- 127 people
- Sponsor
- Abbott Medical Devices
Parkinson Disease
Assessment of Methods Used in Evaluating Balance Rehabilitation in Parkinson's Patients
Balance rehabilitation holds an important place in the treatment of Parkinson's patients. Before and after treatment, patients are evaluated using various measurement methods.
- Trial name
- NCT06562686
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Multiple System Atrophy (MSA)
MSA-01 in Multiple System Atrophy
The purpose of this study is to evaluate whether MSA-01 slows the progression of multiple system atrophy (MSA) and to assess its safety.
- Trial name
- MSA-01_P3 (NCT07446894)
- Testing
- MSA-01
- Where
- 12 sites in Japan
- Volunteers
- 140 people
- Sponsor
- Tokyo University
Parkinson Disease (PD)
Enhancing Nursing Students' Empathy and Learning in Parkinson's Disease Through High-Fidelity Simulation and Blended Learning
The goal of this randomized controlled trial is to evaluate the effectiveness of a multimodal Parkinson's disease-focused intervention on empathy levels and perceived theoretical-practical learning in third-year undergraduate…
- Trial name
- NCT07503418
- Testing
- Blended-learning capsules, High-Fidelity Physical Simulation, Simulated Home Environment
- Where
- Spain
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cadiz
Sleep Disturbances, Parkinsons's Disease
Effects of Rasagiline on Sleep Disturbances in Parkinson's Disease
As the MAO-B inhibitor rasagiline is able to improve motor skills it might have positive effects on sleep disruption by reducing nocturnal akinesia.
- Trial name
- RaSPar (NCT01442610)
- Testing
- Rasagiline
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technische Universität Dresden
Mal de Debarquement Syndrome (MdDS)
Treatments of Mal de Debarquement Syndrome (MdDS) by Habituation of Velocity Storage
Mal de Debarquement Syndrome (MdDS) is an under-recognized but nevertheless common balance disorder, which in most cases occurs after exposure to prolonged passive motion.
- Trial name
- NCT04213079
- Testing
- re-adaptation of the vestibulo-ocular reflex, Habituation of velocity storage of the vestibulo-ocular reflex
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Parkinson's Disease
Apomorphine Nasal Powder in the Treatment of Parkinson's Disease "Off" Periods.
To determine the safety and tolerability of repeated dosing with Apomorphine Nasal Powder in subjects with Parkinson's Disease.
- Trial name
- NCT00346827
- Testing
- Apomorphine Nasal Powder
- Volunteers
- 36 people
- Sponsor
- Britannia Pharmaceuticals Ltd.
Parkinson Disease (PD), Idiopathic Parkinson's Disease
Assessment of the Safety, Immunogenicity, and Pharmacodynamics of TRB-001 in Patients With Early Idiopathic Parkinson's Disease
This is a randomized, placebo-controlled, double-blind, dose-finding phase 1b study with the purpose to assess the safety, immunogenicity and pharmacodynamics of TRB-001 in early idiopathic Parkinson's Disease patients.
- Trial name
- NCT07840027
- Testing
- TRB-001
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Tridem Bioscience FlexCo
Wilson Disease, Liver Failure
Plasma Exchange and Continuous Hemodiafiltration in Treatment of Wilson's Disease-related Liver Failure
This study is to investigate the clinical efficacy of artificial liver support system using combination of plasma exchange and continuous hemodiafiltration in treatment of Wilson's Disease - related liver failure.
- Trial name
- NCT03589820
- Testing
- artificial liver support system
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Parkinson Disease, Idiopathic Parkinson Disease
PA Behavior and HRQoL in Parkinson's Disease Patients Patients: Role of Social Cognitive Variables
The primary aim of the study will be to examine Social Cognitive Theory (SCT) correlates, of physical activity (PA) participation and health-related quality of life (HRQoL) in Parkinson's disease participants.
- Conditions
- Parkinson Disease, Idiopathic Parkinson Disease, Idiopathic Parkinson's Disease, Parkinson Disease, Idiopathic
- Trial name
- PDQ (NCT05575479)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Tourette Syndrome, Tourette Syndrome in Adolescence
A Study to Explore the Effect of Sepranolone in Tourette Syndrome
The study was an open-label, randomized, multicenter, parallel, Phase 2a study in adolescents and adult patients with Tourette syndrome that aimed to explore the efficacy of Sepranolone as a treatment for Tourette syndrome, by…
- Trial name
- NCT05434546
- Testing
- Sepranolone
- Where
- 2 sites in Denmark
- Volunteers
- 26 people
- Sponsor
- Asarina Pharma
Parkinson Disease, Physical Activity
Physical Training Induced Plasticity of Motor Control Mechanisms in Parkinson's Disease Patients
There are experimental evidences of the important role of exercise in the PD, that induces similar effects to pharmacotherapy. So far, the mechanisms of the impact of these changes on the brain subcortical and cortical regions…
- Trial name
- NCT03753503
- Testing
- exercise, conventional physical therapy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Pulmonary Functions, Down Syndrome
Motorized Movement Therapy & Pulmonary Functions in Down Syndrome
To investigate the effects of the addition of motorized movement therapy versus conventional chest physiotherapy alone on pulmonary functions, exercise capacity, and endurance in children with Down Syndrome
- Trial name
- NCT04787861
- Testing
- motorized movement therapy
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Taibah University
Dystonia, Healthy
Brain Anatomy in Dystonia
This study will use high-resolution magnetic resonance imaging (MRI) to look for subtle differences in brain anatomy between patients with focal hand dystonia (also called writer s cramp) and healthy normal volunteers.
- Trial name
- NCT00031369
- Where
- United States
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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