Clinical trials: Movement Abnormalities
Dementia With Lewy Bodies
RewinD-LB - Clinical Study of Neflamapimod in Patients With Dementia With Lewy Bodies
The purpose of this study is to determine whether neflamapimod can improve learning skills, problem solving skills, and memory loss in people diagnosed with DLB.
- Trial name
- NCT05869669
- Testing
- Neflamapimod
- Where
- 40 sites in United States, Netherlands and 1 more
- Volunteers
- 159 people
- Sponsor
- EIP Pharma Inc
Huntington Disease
Characterization and Quantification of Motor Speech Disorders in Huntington's Disease: Identification of Acoustic Markers
The study proposes to identify deviant speech dimensions in patients with HD at presymptomatic and declared stages of the disease, compared to healthy subjects, using the computerized MonPaGe speech protocol.
- Trial name
- TPMH (NCT04630574)
- Testing
- Speech evaluation with the clinical evaluation of dysarthria, complete assessment of the MonPaGe computerized protocol
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Parkinson Disease
i-BiSSkApp for Swallowing Rehabilitation in Parkinson's Disease
Aspiration pneumonia due to dysphagia is a leading cause of death in Parkinson's disease (PD). Dysphagia intervention in the United States involves evaluation at onset of dysphagia symptoms followed by short-term therapy.
- Trial name
- NCT05837520
- Testing
- i-BiSSkApp (tablet application) with swallowing therapy, Traditional behavioral swallowing therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Florida
Parkinson Disease, Epilepsy
Neurofeedback Using Implanted Deep Brain Stimulation Electrodes
Deep brain stimulation (DBS) has become a gold-standard symptomatic treatment option for Parkinson's disease (PD) and is also explored for a variety of other neurological disorders.
- Conditions
- Parkinson Disease, Epilepsy, Essential Tremor
- Trial name
- NCT05101161
- Testing
- Neurofeedback
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- ETH Zurich
Parkinson Disease
Integration of Auditory, and Deep Brain Stimulation to Enhance Deep Sleep in Parkinson's Disease
The study is an open-label trial to validate the local field potential (LFP) activity in the subthalamic nucleus (STN) for slow-wave detection during acoustic stimulation during nighttime sleep in Parkinson's disease patients…
- Trial name
- NCT05184270
- Testing
- Acoustic stimulation
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- Christian Baumann
Parkinson Disease
Evaluation of [18F]MPPF as a Brain Tracer of Serotonin Receptor 5HT1a
The underlying goal of this study is to assess [18F]MPPF PET imaging as a tool to evaluate the activity of the serotonin 5HT1a receptor in the brain of Parkinson Disease (PD) research participants.
- Trial name
- MPPF (NCT01461083)
- Testing
- [18F]MPPF
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson Disease, Constipation
Probiotics-prebiotic Fiber Therapy in Parkinson's Disease Patients With Constipation
A double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics on constipation symptoms and whole gut transit time in patients with Parkinson's disease.PD patients with constipation were randomized to…
- Trial name
- NCT04451096
- Testing
- Probiotics with prebiotic
- Where
- Malaysia
- Volunteers
- 48 people
- Sponsor
- National University of Malaysia
Parkinson Disease, Parkinson
Evaluation of a Computer Game Based Rehabilitation System for Assessment and Treatment of Balance and Gait Impairments in Individuals With Parkinson's Disease.
Examining the feasibility and acceptability of the computer game based rehabilitation system for improving balance, gait and executive function in individuals with PD.
- Trial name
- NCT03232996
- Testing
- Computer game based balance and walking rehabilitation for individuals with Parkinson's Disease
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Idiopathic Parkinson's Disease
Safety and Efficacy Study of Tozadenant to Treat End of Dose Wearing Off in Parkinson's Patients
Phase 3, international, multicenter, randomized, double-blind, placebo-controlled, parallel-group, 3-arm safety and efficacy study (Part A) with an open-label phase (Part B).
- Trial name
- TOZ-PD (NCT02453386)
- Testing
- tozadenant
- Where
- 71 sites in United States, Austria and 5 more
- Volunteers
- 449 people
- Sponsor
- Biotie Therapies Inc.
Parkinson Disease, Deep Brain Stimulation
Validation of HaGuide Software Module Accuracy in Mapping STN Boundaries in Parkinson's Disease Patients Who Underwent DBS Procedure
HaGuide version 1.0 (Neuro-Omega Ltd.) is a software module add-on to the FDA cleared Neuro-Omega System (K123796). It was designed to facilitate the use of Neuro-Omega's system by automatically mapping visually the depth of STN…
- Trial name
- NCT03363724
- Testing
- HaGuide version 1.0 software module
- Volunteers
- 103 people
- Sponsor
- Alpha Omega Engineering Ltd.
Parkinson's Disease (PD), Anxiety
Blood Flow Restriction Aerobic Exercise for Balance and Anxiety in Parkinson's Disease
Reducing balance problems and anxiety severity are the top two research uncertainties for people with Parkinson's disease (PD). Besides having a mutually aggravating relationship between postural impairment and anxiety severity…
- Conditions
- Parkinson's Disease (PD), Anxiety, Postural Balance
- Trial name
- NCT07831980
- Testing
- Aerobic Exercise with Blood Flow Restriction, Aerobic Exercise without Blood Flow Restriction
- Volunteers
- 54 people
- Sponsor
- National Cheng-Kung University Hospital
Parkinson's Disease (PD), Essential Tremor
LIFUS For Neurological Disorders
Low intensity focused ultrasound (LIFUS) has the potential to be used as a means of non-invasive neuro-modulation. To this day, the use of LIFUS is under investigation.
- Conditions
- Parkinson's Disease (PD), Essential Tremor, Orthostatic Tremor, Dystonia
- Trial name
- NCT07417280
- Testing
- LIFUS
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Parkinson Disease, Articular Cartilage Disorder
Femoral Cartilage Thickness in Parkinson's Disease
Parkinson's Disease (PD) is a chronic, progressive, degenerative movement disorder characterized by motor and non-motor findings, and the incidence increases with age.There are different methods for the evaluation of articular…
- Conditions
- Parkinson Disease, Articular Cartilage Disorder, Ultrasonography
- Trial name
- NCT05424848
- Testing
- Ultasonographic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Parkinson's Disease
Pharmacokinetics and Safety Study of LY03003 in Patients With Early-stage Parkinson's Disease
The purpose of this study is to characterize the pharmacokinetics (PK) of LY03003 following multiple escalating intramuscular injections, as compared to Neupro patch and to evaluate the safety and tolerability and preliminary…
- Trial name
- 03003MAD (NCT02055274)
- Testing
- LY03003, Neupro
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Luye Pharma Group Ltd.
Focal Dystonia
Neurophysiology of Task-Specificity of Focal Hand Dystonia
This study will examine how the brain coordinates movement in patients with focal hand dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or abnormal postures.
- Trial name
- NCT00309010
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
A Study to Evaluate Feasibility, Safety, and Clinical Responses of Implanting Autologous Peripheral Nerve Tissue Into the Brain for Non-motor or Motor Symptoms in Patients With Parkinson's Disease Undergoing DBS Surgery
The investigators propose a Phase I single surgical-center, double-blinded randomized parallel clinical trial involving bilateral autologous peripheral nerve tissue (PNT) delivery into the NBM or the alternate target also…
- Trial name
- STAR (NCT06683378)
- Testing
- Reparative Autologous peripheral nerve tissue
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Craig van Horne, MD, PhD
Parkinson Disease
Counterfactual Thinking and Decision-making in Parkinson's Disease
The aim of this research is to verify the ability of counterfactual thinking about medical decisions in individuals affected by Parkinson's Disease when compared to healthy individuals.
- Trial name
- CT_PD (NCT05756543)
- Testing
- Counterfactual Inference Test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Parkinson Disease, Depression
Study of Antidepressants in Parkinson's Disease
The purpose of this study is to find out if two antidepressant medications, paroxetine and venlafaxine, can help control depression in Parkinson's disease, and if these medications affect the motor symptoms of Parkinson's disease…
- Trial name
- SAD-PD (NCT00086190)
- Testing
- paroxetine, venlafaxine
- Where
- 18 sites in United States, Canada and 1 more
- Volunteers
- 115 people
- Sponsor
- University of Rochester
Parkinson's Disease
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease.
Parkinson's disease involves many motor difficulties as well as non-motor ones. Recent research has strongly suggested that exercise is very important for Parkinson's disease.
- Trial name
- NCT01573260
- Testing
- Argentinean Tango classes, Simple pamphlet about the exercise in PD
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Progressive Supranuclear Palsy, Corticobasal Degeneration
Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (APOPARKA)
Treatment of tauopathies such as Progressive Supranuclear Palsy (PSP) and Cortico Basal Degeneration (CBD) remains a major challenge.
- Trial name
- APOPARKA (NCT04786158)
- Testing
- Apomorphine
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.