Clinical trials: Movement Abnormalities
PARKINSON DISEASE (Disorder)
Effect of Hand Rehabilitation on Cognitive Function in Patients With PD
Evidence suggests the association between fine motor skills of the hand and cognitive function, as well as the positive effects of hand rehabilitation on hand function and the effectiveness of cognitive rehabilitation on…
- Trial name
- NCT07702929
- Testing
- Hand Sensorimotor Rehabilitation, Cognitive Remediation
- Where
- Iran
- Volunteers
- 48 people
- Sponsor
- Isfahan University of Medical Sciences
Parkinson's Disease, Essential Tremor
Deep Brain Stimulation (DBS) Data Base Study
The primary goal of this study is to evaluate and compare outcomes, trends, and effectiveness of both awake and asleep Deep Brain Stimulation (DBS) surgical treatments, target selection, targeting accuracy and outcomes in…
- Trial name
- NCT01909531
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Wilson Disease
A Controlled Study of Potential Therapeutic Effect of Oral Zinc in Manifesting Carriers of Wilson Disease
The assumption is that in some of the carriers, the increase in enzymes reflects tissue damage due to excess copper. The reduction of the amount of copper absorbed will decrease excess copper in the liver, which will result in a…
- Trial name
- NCT03659331
- Testing
- Zinc
- Volunteers
- 50 people
- Sponsor
- Prof. Elon Pras
Neurological Diseases or Conditions, Dementia of Alzheimer Type
An Observational Study of Patients Living With Chronic Neurological Diseases
TARGET-NEURO is an observational research study to conduct a comprehensive review of outcomes for patients living with chronic neurological diseases: Alzheimer's disease and related dementia (ADRD), mild cognitive impairment…
- Conditions
- Neurological Diseases or Conditions, Dementia of Alzheimer Type, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NCT05796037
- Volunteers
- 1,500,000 people
- Sponsor
- Target PharmaSolutions, Inc.
Parkinson's Disease
The Effects of Dual Task Training in Individuals With Parkinson's Disease
The primary aim of the proposed project is to characterize dual tasking (DT) deficits to improve motor, cognitive, and quality of life outcomes in individuals with Parkinson's disease (PD).
- Trial name
- NCT02538029
- Testing
- Dual Task Group, Single Task Group
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The Cleveland Clinic
Essential Tremor
Safety and Effectiveness of Unilateral MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor
Essential tremor (ET) is one of the most common movement disorders, significantly impacting patients' quality of life. Many patients do not respond well to medication or cannot tolerate side effects, leaving limited treatment…
- Trial name
- BJGB-ET (NCT07006740)
- Testing
- MR-guided Focused Ultrasound Thalamotomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- meishanshan
Focal Dystonia
Electrophysiological and Neuroimaging Correlates of the Effect of Zolpidem in Patients With Focal Dystonia
To study electrophysiological and imaging correlations of the clinical effectiveness of zolpidem in task-specific dystonia and to elucidate mechanisms underlying its therapeutic effects, patients with focal dystonia will be…
- Trial name
- NCT04692285
- Testing
- Zolpidem
- Where
- 2 sites in Serbia, Slovenia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Parkinson's Disease, Mild Cognitive Impairment
Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive Training
People with Parkinson's disease are at higher risk of cognitive decline, and current treatments cannot fully prevent this. This study explores non-drug ways to support brain function.
- Trial name
- PDCogTSleep (NCT07441915)
- Testing
- Phase-Targeted Auditory Stimulation (PTAS), Digital Cognitive Training (CogT)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Addiction
Prognosis of Behavioral Addiction in Parkinson's Disease
Our hypothesis is that the conventional treatment of Behavioral Addiction in Parkinson's disease is often not effective, and that affects the motor aspects (worsening akinéto-rigid syndrome and / or worsening of dyskinesia due to…
- Trial name
- PROBA-PD (NCT02671240)
- Where
- France
- Volunteers
- 164 people
- Sponsor
- University Hospital, Strasbourg, France
Essential Tremor, Parkinson Disease
Environmental Epidemiology of Essential Tremor
This study's research is devoted to studying the causes of tremor, and especially essential tremor (ET), which is the most common type of tremor.
- Trial name
- RULET (NCT04576676)
- Where
- United States
- Volunteers
- 1,497 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Tourette Syndrome
Thalamic Deep Brain Stimulation for the Treatment of Refractory Tourette Syndrome
This research is being performed to try to understand if the use of deep brain stimulation or DBS can treat the symptoms of Tourette syndrome that do not respond well to current medications.
- Trial name
- NCT01817517
- Testing
- Medtronic Activa Deep Brain Stimulation System
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Psychological Adaptation, Parkinson's Disease
Stress-Busting Program for Caregivers of Patients With Neruological Diseases
Although family caregivers perform an incredibly valuable service for their relatives and the formal health care system, they do so at a considerable cost to themselves both emotionally and physically.
- Conditions
- Psychological Adaptation, Parkinson's Disease, Neurological Disorders
- Trial name
- NCT00122174
- Testing
- Stress Busting Program for family caregivers
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Spasticity, Muscle, Stroke Sequelae
Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin(Dysport®)
Assessing the objective measurement of passive joint mobility (ROM) in the spastic upper limb with Jost's pattern III in patients with post-stroke spasticity after infiltration with BoNT-A allows to objectify the increase in…
- Conditions
- Spasticity, Muscle, Stroke Sequelae, Movement Disorders
- Trial name
- ROM-ICTUS (NCT05151874)
- Testing
- Abobotulinum toxin A
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Parkinson Disease
Reducing Falls With Varenicline in Hypocholinergic Parkinson Disease
This trial aims to test whether one year of Varenicline, when compared to placebo, can reduce fall risk and show improvement in the ability to multitask while walking.
- Trial name
- CRANE (NCT06679374)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Vikas Kotagal
Parkinson Disease
Autocorrelated Rhythmic Auditory Stimulations for Parkinson's Disease Patients
Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)).
- Trial name
- NCT03716674
- Testing
- Metronome
- Volunteers
- 9 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson Disease
Effect of Desmopressin on the Nocturnal Micturition Frequency in Patients With Parkinson Disease
This study will be conducted to study the effect of Desmopressin on the nocturnal micturition frequency in patients with idiopathic Parkinson syndrome.
- Trial name
- DEPOPA (NCT00806468)
- Testing
- Desmotabs
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Johannes Gutenberg University Mainz
Supranuclear Palsy, Progressive
Study of BIIB092 in Participants With Progressive Supranuclear Palsy
The Primary objective of the study is to evaluate the efficacy of BIIB092, compared to placebo, as measured by a change from baseline in the PSP Rating Scale (PSPRS) at Week 52 and to assess the safety and tolerability of…
- Trial name
- PASSPORT (NCT03068468)
- Testing
- BIIB092
- Where
- 86 sites in United States, Australia and 11 more
- Volunteers
- 490 people
- Sponsor
- Biogen
Parkinson Disease, Huntington Disease
A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions
Measurement of metabotropic glutamate receptor type 5 (mGluR5) binding capacity in the brain, may be a valuable tool in the early detection, understanding, or evaluation of Parkinson disease (PD), Huntington disease (HD), Fragile…
- Conditions
- Parkinson Disease, Huntington Disease, Autistic Spectrum Disorders, Fragile X Syndrome
- Trial name
- FPEB (NCT00870974)
- Testing
- [18F]FPEB
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson Disease
Stress Management and Resiliency Training Program for Parkinson's Disease
SMART-PD is an 8-session program designed to decrease the physiological, emotional, cognitive and behavioral effects of stress in participants with Parkinson's disease and their caregivers by teaching cognitive-behavioral…
- Trial name
- SMART-PD (NCT04903769)
- Testing
- Stress Management and Resiliency Training Program for Parkinson's Disease (SMART-PD)
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Stony Brook University
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