Clinical trials: Movement Abnormalities
Parkinson Disease
Feasibility of a Behavioural Activation Protocol to Support People With Parkinson's Enhanced by VR
The proposed research project will involve developing and testing the feasibility of a 6 week Behavioural Activation (BA) programme for people with Parkinson's Disease, which will be enhanced by Virtual Reality exercise…
- Trial name
- BAPP-VR (NCT07038603)
- Testing
- BAPP-VR
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Parkinson's Disease
Outcomes Data of Adipose Stem Cells to Treat Parkinson's Disease
The purpose of this study is to determine the impact that treatment with a cellular concentrate derived from an individual's own fat, known as the stromal vascular fraction (SVF), has on the quality of life of people with…
- Trial name
- NCT02184546
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- StemGenex
Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance
The STAND-UP Study
Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue.
- Trial name
- NCT07195903
- Testing
- Angioplasty or stenting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Francis Hospital, New York
Parkinson's Disease
A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Patients With Parkinson's Disease
A phase Ⅰ/Ⅱ study to evaluate the tolerability, safety, and efficacy of VGN-R09b in pa-tients with Parkinson's disease
- Trial name
- NCT06480461
- Testing
- VGN-R09b
- Where
- China
- Volunteers
- 39 people
- Sponsor
- Shanghai Vitalgen BioPharma Co., Ltd.
Essential Tremor, Parkinson's Disease
Global Registry: ExAblate Neuro MR Guided Focused Ultrasound (MRgFUS) of Neurological Disorders:
A global post approval study to collect safety and effectiveness data related to ExAblate Neuro for the treatment of certain disorders such as Essential Tremor, Parkinson's Movement Disorders, or Neuropathic Pain within the…
- Conditions
- Essential Tremor, Parkinson's Disease, Movement Disorders, Neuropathic Pain
- Trial name
- NCT03100474
- Where
- 9 sites in United States, Canada and 2 more
- Volunteers
- 500 people
- Sponsor
- InSightec
Parkinson Disease
Evaluation of a Semiconductor Camera for the DaTSCAN™ Exam
The semiconductor (cadmium-zinc-telluride, CZT) cameras significantly increase detection sensitivity in Single Photon Emission Computer Tomoscintigraphy (SPECT)(1) .
- Trial name
- VERIDAT (NCT03980418)
- Testing
- DaTSCAN SPECT/CT in VERITON-CT camera
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Central Hospital, Nancy, France
Parkinson Disease
Barre Exercise in Parkinson's
This study asks if a barre exercise program is a feasible and acceptable form of exercise for individuals with Parkinson disease.
- Trial name
- NCT06203990
- Testing
- Barre exercise
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Parkinson Disease
Feasibility Of Objective Measures and Outpatient Washout in Disease Modifying Trials for Parkinson's Disease
This study will evaluate the feasibility of adding objective measures (FDG-PET imaging, wearable biosensors) to a week-long washout protocol in early-stage Parkinson's disease patients.
- Trial name
- NCT06192823
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Movement Disorders
Neurophysiological Studies in Patients With Paroxysmal Hyperkinetic Movement Disorders
This study will use three neurophysiological tests (see below) to determine what areas of the brain are responsible for paroxysmal hyperkinetic movement disorders.
- Trial name
- NCT00056888
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Gait Disorders, Neurologic
Digital GaitCare - Therapy Monitoring in the Home Environment of Patients With Parkinson
Gait disturbances and movement restrictions occur frequently in Parkinson's disease. Patient-centered monitoring with objective aids in the patient's daily life, supports and promotes therapy decisions made by physicians and…
- Trial name
- NCT04931303
- Where
- 5 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Medical Valley Digital Health Application Center GmbH
Parkinson Disease
The Effect of Simple Gymnastics Training for Parkinson's Patients in the Community
The goal of this clinical trial is to explore the impact of Simple Gymnastics Training on Limb motor function and mental health in Parkinson's Patients in the Community (≥60 year old) with swallowing disorders.
- Trial name
- NCT06328218
- Testing
- Simple Gymnastics Training
- Volunteers
- 200 people
- Sponsor
- Copka Sonpashan
Dementia With Lewy Bodies
K0706 for Patients Diagnosed With Dementia With Lewy Bodies
This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB.
- Trial name
- NCT03996460
- Testing
- 192 mg powder of K0706, 384 mg powder of K0706
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Georgetown University
Parkinson Disease
Evaluation of the Personal KinetiGraph™ (PKG™) to Improve Insight Into Parkinson's Disease Status
The primary objective is to understand the utility of Personal KinetiGraph movement recording system data in the clinical management of Parkinson's disease (PD) in routine clinical care at a movement disorders clinic.
- Trial name
- APPRISE (NCT03741920)
- Testing
- Personal KinetiGraph™ (PKG™)
- Where
- 12 sites in United States
- Volunteers
- 231 people
- Sponsor
- Global Kinetics Corporation
Parkinson's Disease, Sleep Fragmentation
Adaptive Neurostimulation to Restore Sleep in Parkinson's Disease (Aim 2)
Parkinson's Disease (PD) is the second most common of the age-related neurodegenerative disorders, affecting over 1,900 adults per 100,000 over the age of 80 in the US.
- Trial name
- NCT05070013
- Testing
- Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Progressive Supranuclear Palsy, Multiple System Atrophy
The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism
Progressive supranuclear palsy (PSP), Multiple system atrophy (MSA) and corticobasal syndrome (CBS) are severe neurodegenerative diseases with rapid progression and no effective treatment.
- Conditions
- Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Syndrome
- Trial name
- NADAPT (NCT06162013)
- Testing
- Nicotinamide Riboside
- Where
- 3 sites in Norway
- Volunteers
- 330 people
- Sponsor
- Haukeland University Hospital
Parkinson Disease
A Study of the Efficacy of IAMT as an Assessment Tool for Prediction of Progression of Parkinson's Disease
The primary objective of this proposal is to examine the efficacy of Improvised Active Music Therapy (IAMT) sessions as an early novel tool for cognitive and motor assessment for individuals with Parkinson's Disease (PD) in…
- Trial name
- Music Therapy (NCT05971459)
- Testing
- Improvised Active Music Therapy
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wilfrid Laurier University
Parkinson Disease
PERsonalized SPEeCh Therapy for actIVE Conversation
Background: Up to 70% of the patients with Parkinson's Disease (PD) experience speech problems, which cause a diminished intelligibility.
- Trial name
- PERSPECTIVE (NCT03963388)
- Testing
- Speech therapy
- Where
- Netherlands
- Volunteers
- 214 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Cognitive-driven ADL Impairment as a Predictor for PDD
Mild cognitive impairment in Parkinson's disease (PD-MCI) is the highest risk factor for Parkinson's disease dementia (PDD). The core feature for differentiating PDD from PD-MCI is the loss of the ability to perform activities of…
- Trial name
- NCT03687203
- Testing
- Functional Activities Questionnaire
- Where
- Germany
- Volunteers
- 182 people
- Sponsor
- University Hospital Tuebingen
Tourette's Disorder (TD)
Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Participants With Tourette's Disorder
To evaluate the long-term efficacy of oral aripiprazole in pediatric participants for the treatment of Tourette's Disorder (TD).
- Trial name
- NCT03661983
- Testing
- Aripiprazole
- Where
- 42 sites in United States, Canada and 1 more
- Volunteers
- 36 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Early-stage Parkinson's Disease
A 18-month Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Oral UCB0599 in Study Participants With Early-stage Parkinson's Disease
The purpose of the study is to assess the safety and tolerability of UCB0599 and to demonstrate the superiority of UCB0599 over placebo with regard to clinical symptoms of disease progression over 12 and 18 months in participants…
- Trial name
- ORCHESTRA (NCT04658186)
- Testing
- UCB0599
- Where
- 115 sites in United States, Canada and 7 more
- Volunteers
- 496 people
- Sponsor
- UCB Biopharma SRL
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