Clinical trials: Movement Abnormalities
Parkinson Disease
Efficacy of Isradipine in Early Parkinson Disease
The purpose of the study is to determine whether treatment with isradipine is effective in slowing the progression of Parkinson disease disability.
- Trial name
- NCT02168842
- Testing
- Isradipine
- Where
- 54 sites in United States, Canada
- Volunteers
- 336 people
- Sponsor
- University of Rochester
Parkinson Disease
Pilates as an Adjuvant Therapy in Parkinson Disease.
Although Pilates has been proposed as a useful rehabilitation strategy in PD, research on its feasibility and potential effects on the motor symptoms and balance with this population is scarce.
- Trial name
- NCT03294031
- Testing
- Pilates, Conventional Exercise
- Volunteers
- 15 people
- Sponsor
- University of Vigo
Parkinson Disease
Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients
At present, there is no cure for Parkinson's disease. The standard treatment involves taking dopaminergic drugs. When drugs lose their effectiveness, they can be supplemented by Deep Brain Stimulation (DBS) therapy.
- Trial name
- AdapGAIT (NCT06791902)
- Testing
- Adaptive DBS
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Jocelyne Bloch
Parkinson Disease, Kinesiophobia
The Effect of Kinesiophobia on Physical Activity, Balance and Falling in Parkinson's Disease Patients
The kinesiophobia; defined as irrational fear of movement, which may occur after painful injury and reduce physical activity. It develops the idea that movement in individuals will cause re-injury and cause additional pain to…
- Conditions
- Parkinson Disease, Kinesiophobia, Physical Activity, Balance
- Trial name
- NCT03827746
- Testing
- Tampa Kinesiophobia Scale, Berg-Balance Test, International Physical Activity Questionnaire-Short Form, Falls Efficacy Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Kültür University
Parkinson Disease
Trial of Xyrem for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson's Disease (PD)
This clinical trial is designed to evaluate the safety and potential efficacy of Xyrem for the treatment of excessive daytime sleepiness (EDS) and nocturnal sleep disturbance in patients with mild to moderate Parkinson's Disease…
- Trial name
- Xyrem (NCT00641186)
- Testing
- sodium oxybate
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Parkinson Disease
Effects of Telerehabilitation-Based Motor and Cognitive Dual-Task Exercise in Patients With Parkinson's Disease
The ability to respond to multiple stimuli is impaired in Parkinson's patients. Traditional rehabilitation approaches focus only on balance and gait training, but individuals with Parkinson's disease need to perform multiple…
- Trial name
- NCT05894473
- Testing
- Motor-Motor Dual Task Physical Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Parkinson's Disease
Carbidopa-Levodopa (CD-LD) ER Alone or in Combination With CD-LD IR to IPX066 Followed by IPX066 Extension Safety Study
The study had three distinct parts and is described as follows: Part 1: To evaluate the dose conversion from CD-LD ER taken alone or in combination with CD-LD IR to IPX066 in subjects with advanced PD To evaluate the utility of…
- Trial name
- NCT01411137
- Testing
- IPX066
- Where
- 8 sites in United States
- Volunteers
- 43 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease
Overcoming Gait Freeze in Parkinson's Disease Using Responsive Cueing
The aim of this pilot/feasibility study is to test if delivering rhythmic vibration cues to the lower legs, specifically in response to gait defects (rather than continuously), can improve walking quality and overcome gait…
- Trial name
- NCT05019469
- Testing
- Rhythmic vibration cueing (lower leg)
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- University of Oxford
Parkinson Disease
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
This trial will study the safety and efficacy of intranasal instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Parkinson's Disease
- Trial name
- NCT05152394
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Parkinson's Disease (PD)
COmedication Study Assessing Mono- and cOmbination Therapy With Levodopa-carbidopa inteStinal Gel
The purpose of this study is to evaluate treatment of advanced Parkinson's Disease (PD) patients on levodopa-carbidopa intestinal gel (LCIG) monotherapy in a routine clinical setting.
- Trial name
- COSMOS (NCT03362879)
- Where
- 30 sites in Austria, Canada and 9 more
- Volunteers
- 412 people
- Sponsor
- AbbVie
Parkinson Disease
Closed-loop DBS in Parkinson's Disease
Closed-loop DBS is an emerging neuromodulation pattern in Parkinson's disease with dyanmic adjustment of stimulation parameters to patients' disease fluctuations and state of activity.
- Trial name
- NCT06012461
- Testing
- Closed-loop DBS stimulation for 24 hours, Open-loop DBS stimulation for 24 hours, Closed-loop DBS stimulation for 72 hours
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Tsinghua University
Mild Dementia, Mild Cognitive Impairment
The Swedish BioFINDER - Primary Care Study
The overall aim of the study is to improve the diagnostic accuracy of AD and cognitive impairment in primary care settings to ensure better care and treatment as well as facilitate correct referrals to specialized memory clinics.
- Conditions
- Mild Dementia, Mild Cognitive Impairment, SCD, Alzheimer Disease
- Trial name
- ADetect (NCT06120361)
- Testing
- Plasma APS 2 score, Plasma p-tau217/np-tau217, Plasma p-tau217
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Skane University Hospital
Parkinson Disease
A Prospective, Randomized, Controlled Trial to Test Safety and Effectiveness of Unilateral Exablate MR-guided Focused Ultrasound Subthalamotomy in Patients With Early-Stage Parkinson's Disease
This prospective, randomized, multicenter study aims to evaluate in Early-Stage Parkinson's Disease (ESPD) patients the safety and effectiveness of treatment with Exablate MRgFUS subthalamotomy vs best medical treatment.
- Trial name
- NCT06584383
- Testing
- Exablate MRgFUS subthalamotomy, Best Medical Treatment
- Where
- 4 sites in Chile, Germany and 1 more
- Volunteers
- 67 people
- Sponsor
- InSightec
Tourette Syndrome, Tic Disorder, Chronic Motor or Vocal
Open-label MNS for Tourette Syndrome
A recent report (Morera Maiquez et al 2020) described reduced tic severity in people with Tourette syndrome during 1-minute epochs of median nerve stimulation (MNS) at 10 Hz.
- Trial name
- NCT05016765
- Testing
- Active, self-directed electrical stimulation of the median nerve
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Washington University School of Medicine
Parkinson's Disease, Alzheimer's Disease
Biomarkers in Neural Disorders
This study seeks to establish the sensitivity and specificity of what appears to be a unique brainstem biomarker of Parkinson's Disease (PD) - an electrically induced olygosynaptic nasotrigeminal reflex response - in…
- Conditions
- Parkinson's Disease, Alzheimer's Disease, Progressive Supranuclear Palsy, Essential Tremor
- Trial name
- NCT02761707
- Testing
- Electrical Brainstem Responses, Olfactory Tests, Visual Deprivation
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation
Evaluation of the Safety and Efficacy of Bilateral Subthalamic Nucleus (SNT) Radiosurgery in Idiopathic Severe Parkinson's Disease Fulfilling Inclusion Criteria for STN Deep Brain Stimulation and Presenting With a Contraindication to Intracerebral Electrode Implantation.
The goal of our trial is to evaluate the tolerance and efficacy of the STN radiosurgery in Parkinsonian patients presenting with the inclusion criteria for the STN stimulation but presenting also with clear contraindications to…
- Conditions
- Parkinson's Disease, With Inclusion Criteria for STN Deep Brain Stimulation, Presenting a Contraindication to Intracerebral Electrode Implantati
- Trial name
- NCT01284699
- Testing
- Gamma Knife radiosurgery
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Wilson Disease
Description of Renal Involvement in Wilson's Disease
Wilson's disease (WD) is a rare genetic disorder that leads to copper accumulation in various tissues, including the liver, nervous system, heart, and kidneys.
- Trial name
- WILKID (NCT07075393)
- Testing
- full renal workup
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
PARKINSON DISEASE (Disorder)
Integrated Motor-Cognitive Training in Parkinson's Disease: A Feasibility Study
Parkinson's disease is a progressive neurodegenerative condition characterized by both motor symptoms (such as bradykinesia, rigidity, tremor, and postural instability) and non-motor symptoms, including cognitive impairments…
- Trial name
- P_Feasibility (NCT07833748)
- Testing
- Combined group motor training and individual digital cognitive stimulation
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- University Hospital of Ferrara
Parkinson Disease
Cognitive Phenotypes in Parkinson's Disease
a data driven approach has identified different cognitive phenotypes in Parkinson's disease (PD) this heterogeneity possibly reflects the diversity of the neuronal damage caused by the disease we hypothesize that the different…
- Trial name
- CogPhenoPark (NCT01792843)
- Testing
- data
- Where
- Netherlands
- Volunteers
- 158 people
- Sponsor
- University Hospital, Lille
Parkinson Disease
Is Remote Physiotherapy Effective for People With Early Parkinson's (PEEP)
Parkinson's disease is a progressive neurodegenerative condition affecting 145,500 people in the UK. The condition impairs movement leading to gait and dexterity problems.
- Trial name
- PEEP (NCT04389138)
- Testing
- Physiotherapy Intervention
- Volunteers
- 40 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
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