Clinical trials: Movement Abnormalities
Essential Tremor
Image-Guided DBS Programming
The objective of this study is to compare the effects of image-guided programming algorithm using various image segmentations vs standard clinical programming on reduction of tremor and patient satisfaction.
- Trial name
- NCT07433699
- Testing
- programming a, programming b
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Parkinson Disease
A Study to Evaluate Safety and Efficacy of KM-819 in Healthy Adults and Participants with Parkinson's Disease
The goal of this study is to test KM-819 in halting or slowing the progression of Parkinson's disease. The study evaluates the safety and tolerability of multiple ascending doses of KM-819 in healthy older adults and participants…
- Trial name
- NCT05670782
- Testing
- KM-819
- Where
- 3 sites in United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- FAScinate Therapeutics Inc.
Idiopathic Parkinson Disease, Dyskinesias
Reliability and Validity Study of the Turkish Version of the Parkinson's Disease Dyskinesia Scale (PDYS-26)
The aim of this methodological study was to investigate the Turkish validity and reliability of the Parkinson's Disease Dyskinesia Scale (PDYS-26).The scale evaluates choreic dyskinesia.Measures the impact of dyskinesia on…
- Conditions
- Idiopathic Parkinson Disease, Dyskinesias, Quality of Life
- Trial name
- NCT07023224
- Testing
- Turkish version of the Parkinson's Disease Dyskinesia Scale (PDYS-26)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Izmir Bakircay University
Parkinson's Disease
Mobile Decision Support System for Nurse Management of Neuromodulation Therapy
The purpose of this study is to test the use of a clinical decision support tool for postoperative care of Parkinson's disease patients who are treated using deep brain stimulation (DBS).
- Trial name
- NCT02474459
- Testing
- iPad-Based Clinical Support Care, Standard Clinical Care
- Where
- 6 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Utah
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Parkinson's Disease
Attributional Style and Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disorder affecting 1-2% of the population over 65 years-old. In addition to the motor impairment characterized by resting tremor, bradykinesia, rigidity and postural…
- Trial name
- ParkAIHQ (NCT03371277)
- Testing
- Medical visit for specific questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CHU de Reims
Parkinson Disease
The Efficacy of a Remote Cognitive Remediation Therapy (CRT) Program on Parkinson's Disease
Purpose/Goal: To determine if a remote computerized cognitive remediation program (CRT) can stabilize or improve cognitive functioning in a group of patients from the New York Institute of Technology Academic Health Care Center…
- Trial name
- NCT04955275
- Testing
- Cognitive Remediation Therapy Program (BrainHQ)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York Institute of Technology
Parkinson Disease
Expanding the Therapeutic Window of Deep Brain Stimulation in Parkinson's Disease by Means of Directional Leads
Exploring directional lead
- Trial name
- NCT04093544
- Testing
- Deep brain stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Parkinson Disease, PARK1
Molecular and Functional Imaging in SNCA, Parkin and PINK1
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized clinically by bradykinesia, resting tremor, rigidity, and postural instability.
- Conditions
- Parkinson Disease, PARK1, PARK2
- Trial name
- NCT04084509
- Volunteers
- healthy volunteers welcome
- Sponsor
- King's College London
Parkinson Disease
Effect of a Lipidic and Proteic Controlled Diet on Parkinson's Disease
Parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. Ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but…
- Trial name
- NCT02687698
- Testing
- Ketogenic diet
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Padova
Parkinson's Disease
Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes
The purpose of this study is to determine the potential for a Parkinson's Disease (PD) -specific breath signature as a non-invasive screening tool for identifying PD patients with inflammation, tracking the progression of…
- Trial name
- NCT02749214
- Testing
- Blood Sample Collection, Breath Sample Collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
Parkinson Disease
Synaptic Density and Progression of Parkinson's Disease.
AIM: To assess synaptic density and to investigate the potential relationship of regional synaptic loss with motor and non-motor symptoms and with disease progression in the human brain in vivo in patients with PD.
- Trial name
- NCT04243304
- Testing
- 11C-UCB-J PET-CT, 18F-PE2I PET-MR
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Schizophrenia, Tardive Dyskinesia, Metabolic Syndrome
The Monitor of Serum Prolactin Level in a 3 Months Aripiprazole Trial
A short term post-market monitoring of serum prolactin level change among patients with schizophrenia shifting from other antispychotics to different dosages of aripiprazole.
- Trial name
- NCT00468533
- Testing
- Aripiprazole
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Yu-Li Hospital
Dementia, Dementia, Vascular
Home-based Family Caregiver-delivered Music and Reading Interventions for People With Dementia
This international study evaluates the impact of home-based caregiver-delivered music and reading interventions for people with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia, Mixed
- Trial name
- HOMESIDE (NCT03907748)
- Testing
- Music Intervention, Reading Intervention
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 864 people
- Sponsor
- Anglia Ruskin University
Parkinsonian Syndrome, Parkinson
The Study of the Impact of Disclosing Imaging Study Information to Trial Participants
The overall goal of the study is to evaluate how research participants in Parkinson Disease studies that include brain imaging with a dopamine transporter ligand choose to receive the imaging data and what is the impact of the…
- Trial name
- NCT00354003
- Testing
- A series of questionnaires
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson s Disease
The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease
This study aimed to evaluate the clinical efficacy and safety of temporal interference stimulation (TIS) targeting different targets in patients with Parkinson's disease (PD), and to investigate the associated neurophysiological…
- Trial name
- NCT07572903
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 96 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Movement Disorders
rTMS Effect in Functional Psychogenic Movement Disorders Applied Alone Then Combined With Hypnotherapy
The management of functional psychogenic movement disorders (FNPMD) is challenging for neurologists and psychiatrists and only comprehensive multidisciplinary treatment programme can be worthwhile for these patients (Moene et al…
- Trial name
- MOVHYSTIM (NCT02471066)
- Testing
- rTMS
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease, Orthostatic Hypotension
Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension
Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
- Trial name
- HYPOPARK (NCT07139756)
- Testing
- Lower body negative pressure
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Lewy Body Dementia, Visual Hallucinations
Study Evaluating Nelotanserin for Treatment of Visual Hallucinations in Subjects With Lewy Body Dementia
This study seeks to evaluate safety and efficacy of Nelotanserin for the treatment of visual hallucinations in subjects with Lewy body dementia.
- Trial name
- NCT02640729
- Testing
- Nelotanserin
- Where
- 10 sites in United States
- Volunteers
- 30 people
- Sponsor
- Axovant Sciences Ltd.
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