Clinical trials: Movement Abnormalities
Shy-Drager Syndrome, Multiple System Atrophy
Water and Sudafed in Autonomic Failure
The specific aim of this study is to determine whether water ingestion potentiates the pressor response to pseudoephedrine in patients with primary disorders of autonomic failure.
- Trial name
- NCT02149901
- Testing
- Pseudoephedrine + 480 ml water, Pseudoephedrine + 50 ml water
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Vanderbilt University
Hemophilia
Therapeutic Exercise in Patients With Hemophilia
Objectives: To assess the efficacy of performing a therapeutic exercise program, compared with usual care, on pain relief, range of movement and self-perceived quality of life in patients with hemophilia Design: Quantitative…
- Trial name
- Hemofisio (NCT04114448)
- Testing
- Therapeutic exercise, Usual physical therapy care
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- University of Seville
Huntington's Disease
Deep Brain Stimulation of the Globus Pallidus in Huntington's Disease
This is a single centre, controlled phase I study, which evaluates safety and efficacy of stimulation of lower caudal two contacts (GPI) vs. upper cranial two contacts (GPE) in Huntington´s disease (HD).
- Trial name
- NCT00902889
- Testing
- Stimulation
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Huntington Disease
Neurobiological Predictors of Huntington's Disease (PREDICT-HD)
The purpose of this trial is to study early brain and behavioral changes in people who have the gene expansion for Huntington's disease, but are currently healthy and have no symptoms.
- Trial name
- PREDICT-HD (NCT00051324)
- Where
- United States
- Volunteers
- 1,700 people
- Sponsor
- Jordan Schultz
Parkinson's Disease
Effects of the Mechanical Peripheral Stimulation for Parkinson's Disease Rehabilitation
The purpose of this study is to evaluate safety and effectiveness of the peripheral mechanical stimulation of the feet on gait variables, clinical status, risk of falls, BDNF levels, immunological profile and brain functional…
- Trial name
- NCT02594540
- Testing
- Mechanical Peripheral Stimulation (GONDOLA)
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Progressive Supranuclear Palsy, Cognitive Impairment
Neuropsychological Evaluation for Early Diagnosis of PSP
The aim of this study is to better understand the nature of the cognitive decline in Progressive Supranuclear Palsy, the time of its development and the relation with the other cardinal features of the disease.
- Trial name
- NCT03478124
- Testing
- Cognitive evaluation
- Volunteers
- 112 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Dyskinesia, Drug-Induced, Parkinson Disease
rTMS as an Intervention for Levodopa-induced Dyskinesia
The proposed study investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for levodopa-induced dyskinesia (LID) in Parkinson's Disease (PD).
- Trial name
- ADAPT-LIDI (NCT06570824)
- Testing
- active TMS
- Where
- Denmark
- Volunteers
- 68 people
- Sponsor
- Danish Research Centre for Magnetic Resonance
Multiple System Atrophy
Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA
Evaluate the effects of L-Threo DOPS on orthostatic hypotension symptoms and other non-motor symptoms in patients with Multiple System Atrophy (MSA) after 12 weeks following randomization to continued therapy with droxidopa or…
- Trial name
- DOPS-AMS (NCT02071459)
- Testing
- L-Threo DOPS
- Where
- 13 sites in France
- Volunteers
- 107 people
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease and Parkinsonism
Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients
The objective of this study was to determine the effects of protocols of repetitive transcranial magnetic stimulation (rTMS) therapy based on the functional reserve of each patient with Parkinson's disease, compared to…
- Trial name
- NCT06350617
- Testing
- High-Frequency, ipsilateral M1, High-Frequency, bilateral M1, High-Frequency, Lt. DLPFC
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Parkinsonism
Efficacy and Safety of Astragalus for Non-motor Symptoms of α-Synucleinopathy
α-Synucleinopathy is a cluster of neurodegenerative disease with motor and non-motor symptom. However, there is still a lack of research on the treatment for non-motor symptoms of α-synucleinopathy, especially autonomic…
- Trial name
- NCT05506891
- Testing
- Physical therapy group, Astragalus
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fujian Medical University Union Hospital
Dystonia-Parkinsonism, Adult-Onset, Parkinson Disease
Unlocking Dystonia From Parkinson's Disease With Directional DBS Technology
This study occurs during five visits that are already scheduled as part of "Biomarkers to Guide Directional DBS for Parkinson's Disease" (ClinicalTrials.gov Identifier: NCT03353688).
- Trial name
- NCT03409120
- Testing
- Boston Scientific Vercise PC IPG with directional DBS lead
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Alabama at Birmingham
Multiple System Atrophy, Progressive Supranuclear Palsy
Neuroprotection and Natural History in Parkinson's Plus Syndromes (NNIPPS)
NNIPPS is a clinical trial of riluzole (a drug previously shown to slow down the rate of progression og amyotrophic lateral sclerosis-ALS; Lou Gehrig's disease) involving nearly 800 people diagnosed with the 'parkinson plus'…
- Trial name
- NCT00211224
- Testing
- Riluzole
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- King's College London
Parkinson's Disease
Deep Brain Stimulation (DBS) for the Treatment of Parkinson's Disease
The purpose of this study is to evaluate the safety and effectiveness of Boston Scientific's Vercise Deep Brain Stimulation (DBS) system in the treatment of patients with with advanced, levodopa-responsive bilateral Parkinson's…
- Trial name
- INTREPID (NCT01839396)
- Testing
- Deep Brain Stimulation
- Where
- 22 sites in United States
- Volunteers
- 313 people
- Sponsor
- Boston Scientific Corporation
Parkinson Disease, Gait Disorders, Neurologic
Automated Mechanical Peripheral Stimulation to Treat Freezing of Gait in Patients With Parkinson's Disease and STN-DBS
The objective is to investigate whether AMPS (Automated Mechanical Peripheral Stimulation) is effective in reduction of FOG measured via the FOG-AC (Freezing Of Gait Assessment Course) in people with Parkinson Disease and STN-DBS…
- Trial name
- AMBITION (NCT04831879)
- Testing
- GONDOLA AMPS
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Gondola Medical Technologies SA
Essential Tremor, Deep Brain Stimulation
Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect
The proposed study aims to characterize ataxia occurring in essential tremor and essential tremor with DBS.
- Conditions
- Essential Tremor, Deep Brain Stimulation, Ataxia, Cerebellar Diseases
- Trial name
- ATAX (NCT03769961)
- Testing
- No intervention
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Essential Tremor
A Clinical Trial of PRAX-114 in Participants With Essential Tremor
This is a 2-part clinical trial to evaluate the safety, tolerability, pharmacokinetics, and efficacy of PRAX-114 in participants with essential tremor (ET).
- Trial name
- NCT05387642
- Testing
- 10 mg PRAX-114 or 20 mg PRAX-114
- Where
- 3 sites in United States
- Sponsor
- Praxis Precision Medicines
Parkinson Disease
Mister Parkinson: Educational Therapy in Parkinson's Disease (PD)
Parkinson's disease is multidimensional disorders characterized by motor and non-motor symptoms such as behavioral and psychological symptoms, autonomic disturbances and other non-motor symptoms.
- Trial name
- NCT04378127
- Testing
- Educational program
- Volunteers
- 120 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson Disease, Gait Disorders, Neurologic
Immersive Virtual Reality to Improve Gait in Parkinson's Disease
Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)).
- Trial name
- NMSK-LH02 (NCT03727529)
- Testing
- Treadmill + VR, Treadmill
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson's Disease
Pharmacokinetics,Pharmacodynamics,Efficacy and Safety of HRG2010 in Parkinson's Disease Patients With Motor Fluctuations
The study is a multicenter, randomized, open-label, active-controlled, Phase II clinical study. The aim of this trial is to evaluated the pharmacokinetics, pharmacodynamics,efficacy and assessed the safety of HRG2010 compared…
- Trial name
- NCT06614153
- Testing
- HRG2010(I), HRG2010(II), Sustained-release Carbidopa/Levodopa
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Parkinson Disease
Task-priority Effects on Postural-suprapostural Task in Patients With Parkinson's Disease
Postural-suprapostural task is defined as postural control takes place while at least one other concurrent task is being performed.
- Trial name
- NCT03298503
- Testing
- task-priority strategies
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
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