Clinical trials: Movement Abnormalities
Parkinson Disease
A Study to Evaluate the Safety and Efficacy of ExAblate Subthalomotomy for the Treatment of Parkinson's Disease Motor Features
The objective of this study is to test the efficacy and safety of unilateral subthalamotomy performed using the ExAblate System for the treatment of Parkinson's disease (PD) motor features.
- Trial name
- NCT03454425
- Testing
- Exablate Subthalamotomy
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- InSightec
PARKINSON DISEASE (Disorder)
AI-based Progression and Medication Response Prediction Study in Parkinson's Disease
The study aims to provide initial PoC validation data of two AI models to predict disease progression and treatment side effects in PD patients using as input patients' demographic, clinical and genetic information, as well as…
- Trial name
- AI-PMP (NCT07189468)
- Testing
- Smartwatch and mobile application
- Where
- 4 sites in France, Germany and 2 more
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease, Dysphagia
Novel Management of Airway Protection in Parkinson's Disease: A Clinical Trial
Currently, there are no efficacious behavioral treatment approaches to address uncompensated aspiration, or aspiration without appropriate cough response, in Parkinson's disease (PD).
- Conditions
- Parkinson's Disease, Dysphagia, Dystussia
- Trial name
- NCT02927691
- Testing
- EMST, smTAP
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Teachers College, Columbia University
Lewy Body Disease, Lewy Body Variant of Alzheimer Disease
Stimulation of Cingulo-opercular Alertness Network
Fluctuations in alertness are very common in persons with Lewy body dementias and are a major source of disability. Changes in a chemical messenger molecule called acetylcholine within certain brain regions may play a role in…
- Conditions
- Lewy Body Disease, Lewy Body Variant of Alzheimer Disease, Lewy Body Dementia With Behavioral Disturbance
- Trial name
- SCAN (NCT04817891)
- Testing
- HD-tDCS
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Parkinson Disease
The Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
This study is a double-blinded randomized study examining the efficacy of the double-site (M1+SMA) repetitive transcranial magnetic stimulation on Freezing of Gait (FOG) in patients with Parkinson's disease.
- Trial name
- NCT06415682
- Testing
- SMA+M1 Transcranial Magnetic Stimulation, M1 Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease, Epilepsy
Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.
- Trial name
- BAG-OSMOV (NCT06241924)
- Testing
- High Resolution Electroencephalogram (EEG-HR), Stereo-electro-encephalography (SEEG)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Motor OFF Episodes Associated With Parkinson's Disease
A Study of an Investigational Drug to See How it Affects the People With Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes) Compared to an Approved Drug Used to Treat People With Parkinson's Disease Complicated by Motor Fluctuations ("OFF" Episodes)
A study of an investigational drug to see how it affects the people with Parkinson's Disease complicated by motor fluctuations ("OFF" Episodes) compared to an approved drug used to treat people with Parkinson's Disease…
- Trial name
- NCT03391882
- Testing
- APL-130277, subcutaneous apomorphine
- Where
- 31 sites in Austria, France and 4 more
- Volunteers
- 113 people
- Sponsor
- Sumitomo Pharma America, Inc.
Parkinson's Disease, Chronic Appendicitis
A Study Assessing the Effects of Acupuncture in Parkinson's Disease Patients With Chronic Appendicitis
The incidence of PD is high, and when the disease is serious to a certain extent, the effect of drugs to control symptoms decreases, resulting in a significant reduction in the quality of life of patients.
- Conditions
- Parkinson's Disease, Chronic Appendicitis, Acupuncture
- Trial name
- NCT06304285
- Testing
- Acupuncture treatment
- Where
- China
- Volunteers
- 84 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China
Parkinson Disease
Evaluation of the Impact of a Personalized Program of Adapted Physical Activates in Patients With Parkinson Disease
Our study aims to compare the effects of a standard care plan to one using adapted physical activity in patients with Parkinson Disease.
- Trial name
- ACTIPARK (NCT03244813)
- Testing
- Personalized activity program
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Parkinson Disease
An Exploratory Study Investigating Safety, Tolerability and Pharmacokinetics of Ascending Doses of Lu AE04621 in Parkinson Disease Patients
To evaluate the safety, tolerability, pharmacokinetics, and efficacy of the Lu AE04621 and metabolite after ascending oral doses of Lu AE04621 in patients with Parkinson's Disease.
- Trial name
- NCT02649608
- Testing
- 0.04 mg Lu AE04621, 0.08 mg Lu AE04621, 0.2 mg Lu AE04621
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- H. Lundbeck A/S
Parkinson's Disease, Physical Exercise
Research on the Effect and Mechanism of Aerobic Exercise on PD
This trial is expected to recruit patients with primary Parkinson's disease and give them four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
- Trial name
- NCT04651140
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Parkinson Disease
Comparison of Different Non-invasive Electrical Stimulation Protocols to Facilitate Rehabilitation in Parkinson's Disease Subjects With Postural Instability and Gait Disorders
The trial will include 51 adult participants with Parkinson's disease and postural instability and gait disorders (PD-PIGD) and 20 age- and sex-matched healthy controls.
- Trial name
- NCT06868160
- Testing
- Rehabilitation, tDCS, tsDCS (first cycle)
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Dementia With Lewy Bodies (DLB)
Cognitive Effects of Oral p38 Alpha Kinase Inhibitor Neflamapimod in Dementia With Lewy Bodies
This is a Phase 2, multi-center, randomized, double-blind, placebo-controlled, proof-of-principle study of neflamapimod versus matching placebo (randomized 1:1) administered with food for 16 weeks in subjects with DLB.
- Trial name
- AscenD-LB (NCT04001517)
- Testing
- Neflamapimod
- Where
- 24 sites in United States, Netherlands
- Volunteers
- 91 people
- Sponsor
- EIP Pharma Inc
Angelman Syndrome
Minocycline in the Treatment of Angelman Syndrome
There is mounting evidence to suggest that a treatment for Angelman syndrome is not just possible, but probable. The lack of known molecular targets associated with AS has hampered the development of specific therapeutics.
- Trial name
- NCT01531582
- Testing
- minocycline
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of South Florida
Huntington's Disease
A Study of the Novel Drug Dimebon in Patients With Huntington's Disease
This study will evaluate the safety of 3 months of Dimebon dosing and the efficacy of Dimebon in improving cognitive, motor, and overall function in subjects with Huntington's Disease.
- Trial name
- DIMOND (NCT00497159)
- Testing
- Dimebon
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Medivation, Inc.
Parkinson Disease
Development of a Multifunctional Rehabilitation Device for Persons With Parkinson's Disease
The researchers have developed a multifunctional rehabilitation device that will be tested in this feasibility trial across three sub-studies: (i) dual session in-lab; (ii) multi-session in-lab and (iii) in the participant's…
- Trial name
- NCT05586490
- Testing
- Multifunctional RehabilitationDevice (MRD), existing standard rehabilitation device
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Michigan
Parkinson Disease
Initial Investigation of [18F]P17-059 in Parkinson's Disease Patients and Healthy Volunteers
This study investigates the initial safety profile of [18F]P17-059 in healthy volunteers including dosimetry determination, and compares regional brain uptake and kinetics of [18F]P17-059 in Parkinson's disease patients with…
- Trial name
- NCT03903549
- Testing
- [18F]P17-059
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Five Eleven Pharma, Inc.
Parkinson's Disease With End of Dose Wearing Off
Effects of Carbidopa/Levodopa/Entacapone on Motor Function and Quality of Life in Patients With Parkinson's Disease
To assess motor function and quality of life (QoL) in Parkinson's disease (PD) subjects with end-of-dose wearing off, comparing immediate and delayed switch to carbidopa/levodopa and entacapone.
- Trial name
- NCT00219284
- Testing
- Carbidopa/levodopa/entacapone
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 359 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson's, Anosognosia
Lack of Awareness of Symptoms (Anosognosia) in PD: An Observational Study for People With Parkinson's
Anosognosia is a recognised condition for people with Parkinson's, and is the result of physiological damage on brain structure.
- Trial name
- NCT02561715
- Testing
- Questionnaires
- Where
- United Kingdom
- Sponsor
- University of Birmingham
Parkinson's Disease, Dyskinesia
A Study of Efficacy and Safety of Eltoprazine HCl for Treating Levodopa-induced Dyskinesia in Parkinson's Disease Patients
The purpose of this study is to evaluate the safety, tolerability and efficacy of eltoprazine to treat levodopa-induced dyskinesia in patients with Parkinson's disease
- Trial name
- NCT02439125
- Testing
- Eltoprazine HCl
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Amarantus BioScience Holdings, Inc.
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