Clinical trials: Movement Abnormalities
Parkinson Disease
Safety, Tolerability and Effects of Mannitol in Parkinson's Disease
Parkinson's disease is a progressive neurodegenerative disease that causes disabling motor and cognitive impairments. Currently, no disease-modifying therapy exists for this disease.
- Trial name
- PD-mannitol (NCT03823638)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Communication Disorder, Healthy
Central Mechanisms in Speech Motor Control Studied With H215O PET
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of…
- Conditions
- Communication Disorder, Healthy, Stuttering, Tourette Syndrome
- Trial name
- NCT00001308
- Where
- United States
- Volunteers
- 1,163 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Huntington Disease
Adapted Physical Activity Effect on Abilities and Quality of Life of Huntington Patients and Relatives During Rehab Stay
Intro: Huntington's disease is a neurodegenerative disease that affects the brain, inducing a dysfunction and death of the middle spiny striatal projection neurons and a progressive alteration of cognitive and motor functions…
- Trial name
- HUNT'ACTIV (NCT04917133)
- Testing
- Adapted Physical Activity program, Control
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Effect of Levodopa on Postural Motor Learning in Parkinson Disease
The primary goal of this project is to gain a better understanding of whether and how levodopa (a common anti-Parkinson disease medication) alters postural motor learning in people with Parkinson disease.
- Trial name
- NCT02239978
- Testing
- Postural perturbation
- Where
- 3 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Parkinson Disease, Cognition Disorder
The Role of EEG in Identifying Cognitive Changes in Parkinson's Disease
This study is a group controlled clinical trial. Parallel study, patients aged 40-80 years, with Parkinson disease. Twelve sessions, three times a week, for 30 minutes.
- Conditions
- Parkinson Disease, Cognition Disorder, EEG With Abnormally Slow Frequencies
- Trial name
- NCT06145776
- Testing
- tDCS + tredmill training (Standart trehab training), Cognitite-motor Dual Task Training (DT training)
- Where
- 2 sites in Brazil
- Volunteers
- 36 people
- Sponsor
- Federal University of Paraíba
PARKINSON DISEASE (Disorder)
TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients.
- Trial name
- PD TIS (NCT07480317)
- Testing
- Temporal Interference Stimulation (130 Hz), Temporal Interference Stimulation (40 Hz)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Congenital Hyperinsulinism, Neuroblastoma
18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety
Single centre prospective cohort phase III study of 18F-DOPA PET/CT imaging in specific patient populations: 1. Pediatric patients with congenital hyperinsulinism 2. Pediatric patients with neuroblastoma 3.
- Conditions
- Congenital Hyperinsulinism, Neuroblastoma, Neuroendocrine Tumors, Parkinson Disease
- Trial name
- NCT03042416
- Testing
- 18F-DOPA
- Where
- Canada
- Volunteers
- 400 people
- Sponsor
- University of Alberta
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Parkinson's Disease
Investigation of Cogane (PYM50028) in Early-stage Parkinson's Disease (CONFIDENT-PD)
A study to test the therapeutic benefit of the compound PYM50028, versus placebo, in treating early-stage Parkinson's disease. Therapeutic benefit will be assessed using the Unified Parkinson's Disease Rating Scale (UPDRS).
- Trial name
- CONFIDENT-PD (NCT01060878)
- Testing
- PYM50028
- Where
- 111 sites in United States, Canada and 8 more
- Volunteers
- 425 people
- Sponsor
- Phytopharm
Healthy, Focal Dystonias
Role of Dopamine Receptors in Primary Focal Dystonias
Dystonia is a disabling movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting or abnormal postures that may afflict 250,000 people in the U.S.
- Trial name
- NCT01373840
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease
Fixed-Dose Trial in Early Parkinson's Disease (PD)
The purpose of this study is to evaluate the clinical efficacy, safety and pharmacokinetics (PK) of 2 fixed doses of tavapadon and placebo in participants with early PD.
- Trial name
- TEMPO-1 (NCT04201093)
- Testing
- Tavapadon
- Where
- 77 sites in United States, Australia and 10 more
- Volunteers
- 529 people
- Sponsor
- AbbVie
Tourette Syndrome, Chronic Tic Disorder
VoIP Delivered Behavior Therapy for Tourette Syndrome
The purpose of this research is to examine the preliminary efficacy, feasibility, and acceptability of Voice over Internet Protocol delivered behavior therapy for Tourette Syndrome through in a randomized waitlist-controlled…
- Trial name
- NCT02247206
- Testing
- Behavior Therapy for Tics (CBIT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Wisconsin, Milwaukee
Parkinson's Disease
Phase II Subthalamic Nucleus (STN) vs. Globus Pallidus (GPi) Trial
The goal of the second phase of the study is to determine if simultaneous bilateral subthalamic nucleus stimulation or simultaneous bilateral globus pallidus stimulation is more effective in reducing symptoms of Parkinson's…
- Trial name
- NCT01076452
- Testing
- Bilateral Deep Brain Stimulation
- Where
- 14 sites in United States
- Volunteers
- 299 people
- Sponsor
- US Department of Veterans Affairs
IDIOPATHIC PARKINSON'S DISEASE
Rotigotine Versus Placebo As Double Blind Study To Evaluate The Efficacy In Early Stage Idiopathic Parkinson's Disease Patients
The primary objective is to demonstrate that the Rotigotine transdermal patch is efficacious in Chinese subjects with early-stage idiopathic Parkinson's disease.
- Trial name
- NCT01646268
- Testing
- Rotigotine
- Where
- 24 sites in China
- Volunteers
- 249 people
- Sponsor
- UCB Pharma
Parkinson Disease
Support + High Intensity Functional Training for Parkinson's
Parkinson's is the fastest growing neurological disorder in the world. With more people living with Parkinson's than ever before, there is an urgent need for interventions that improve health and reduce disability.
- Trial name
- SHIFT-PD (NCT05225506)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Arkansas Colleges of Health Education
Parkinson's Disease
Safety and Tolerability Trial of Switching From Ropinirole to Rotigotine
This is a Phase 3b, open-label, multicenter trial to assess the safety and tolerability of switching from ropinirole therapy to the rotigotine transdermal system and its effect on symptoms in subjects with idiopathic Parkinson's…
- Trial name
- NCT00593606
- Testing
- Rotigotine
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Parkinson Disease
The Effect of Exercise Intervention on Posture, Trunk Flexibility and Spine Function in Patients With Parkinson's Disease
The primary goal of this clinical trail is to compare the effect of a five-week specific motor interventions on the postural alignment, trunk range of motion and spine function in patients with Parkinson's disease.
- Trial name
- NCT06536478
- Testing
- exercise, education
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
First-in-Human Single and Multiple Dose of HL-400
This is a randomized, double-blind, placebo-controlled, dose-escalation study in healthy subjects to evaluate the safety, tolerability, pharmacokinetics of HL-400 (a NLRP3 inhibitor) following oral single and multiple ascending…
- Trial name
- NCT06997484
- Testing
- HL-400
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Highlightll Pharmaceutical (USA) LLC
Parkinson's Disease, Nocturia
Melatonin for Nocturia in Parkinson's Disease
This is an an open label clinical trial of sustained-release Melatonin 2mg once daily for 12 weeks in patients with Parkinsons's Disease reporting nocturia, defined as getting up regularly at night > twice to pass urine.
- Trial name
- NCT02359448
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Shy-Drager Syndrome, Orthostatic Hypotension
Droxidopa in Treating Patients With Neurogenic Hypotension
Please note that the continuation study can be found at http://clinicaltrials.gov/show/NCT00633880. RATIONALE: Neurogenic hypotension is a fall in blood pressure that occurs when one moves from a lying down to a standing position…
- Trial name
- NCT00004478
- Testing
- droxidopa
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
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