Clinical trials: Movement Disorder
Obstructive Sleep Apnea
Validation of an Integrated Digital Solution (SUNrise®) Versus Polysomnography for Obstructive Sleep Apnea Diagnosis
Validation of an integrated digital solution (SUNrise®) of mandibular movement automatic analysis by artificial intelligence versus polysomnography for obstructive sleep apnea diagnosis: a prospective, randomized, parallel-arm…
- Trial name
- SUNSAS (NCT05057975)
- Testing
- Sunrise, polysomnography
- Where
- 19 sites in France
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- Sunrise
Parkinson Disease, Progressive Supranuclear Palsy
Oxford Study of Quantification in Parkinsonism
The OxQUIP (Oxford QUantification In Parkinsonism) study is recruiting patients with Parkinson's Disease and Progressive Supranuclear Palsy.
- Trial name
- OxQUIP (NCT04139551)
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Inherited Movement Disorders, Spinocerebellar Ataxias
Biomarker Research in Inherited Movement Disorders
Inherited movement disorders are rare conditions, whose cumulative prevalence are in the order of 5-10/100,000 inhabitants, in most cases progressive and can lead to a significant loss of autonomy after one or more decades of…
- Conditions
- Inherited Movement Disorders, Spinocerebellar Ataxias, Hyperkinetic Disorders
- Trial name
- BIOMOV (NCT05034172)
- Testing
- Clinical follow-up
- Where
- France
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Bioavailability and Bioequivalence Study of Two Different Sources of Opicapone
The purpose of this study is to evaluate the bioavailability and the bioequivalence between two active pharmaceutical ingredient (API) sources of opicapone (OPC) at two different dosage strengths (25 mg and 50 mg) after a single…
- Trial name
- NCT03116295
- Testing
- Opicapone (OPC)
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Dementia, Mild Cognitive Impairment (MCI)
Comprehensive Assessment of Neurodegeneration and Dementia
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits.
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Impairment, Parkinson's Disease (PD)
- Trial name
- COMPASS-ND (NCT03402919)
- Where
- 19 sites in Canada
- Volunteers
- 1,573 people, healthy volunteers welcome
- Sponsor
- McGill University
Multisystemic Atrophy
Motor Activation in Multiple System Atrophy and Parkinson Disease: a Positron Emission Tomography (PET) Study
Background: Multiple System Atrophy (MSA) is an atypical parkinsonian syndrome including cerebellar impairment and poor response to dopatherapy.
- Trial name
- MSAJOY (NCT01044992)
- Testing
- H215O PET, Levodopa
- Where
- 4 sites in France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Diffuse Lewy Body Disease, Dementia With Lewy Bodies
Imaging Inflammation in Patients With Parkinson's Disease Dementia or Dementia With Lewy Bodies
This study uses a special type of scan called a positron emission tomography (PET) scan to take pictures of the brain. During the PET scan, a special dye called 11C-PBR28 is injected into the body.
- Conditions
- Diffuse Lewy Body Disease, Dementia With Lewy Bodies, Parkinson's Disease Dementia
- Trial name
- NCT02702102
- Testing
- 11C-PBR28
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Columbia University
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson, Parkinson Disease
Neuroplasticity in Parkinson's Disease
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes…
- Trial name
- NCT05286736
- Testing
- Neuroimaging, Quantitative assessments
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Participants
Study to Evaluate the Pharmacokinetics (Movement of Drugs Within the Body), Safety and Tolerability of Brazikumab in Healthy Chinese and White Participants
This is a Phase I, single-centre, open-label, parallel-group, single dose study to evaluate the pharmacokinetics, safety and tolerability of Brazikumab in healthy male and female Chinese participants and healthy male and female…
- Trial name
- NCT05033431
- Testing
- Brazikumab
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Movement, Abnormal, Lower Extremity Problem
Gluteal Activation Plus Movement Retraining
The purpose of this study is to determine if an isometric gluteal activation home exercise program (HEP) combined with a movement retraining program utilizing feedback cues produces significant changes in scores on the Forward…
- Trial name
- NCT07293039
- Testing
- Control HEP focusing on isometric gluteal activation, Experimental HEP focusing on isometric gluteal activation plus a movement retaining program
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Movement Disorders, Muscle Tone
Massage and Cold Water Immersion on Movement Variability After Fatigue in Swimmers
The goal of this clinical trial is to investigate the effectiveness of post-exercise massage and cold-water immersion compared to control in young elite swimmers.
- Conditions
- Movement Disorders, Muscle Tone, Perceived Exertion
- Trial name
- NCT04541901
- Testing
- Massage, Cold water immersion
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Flávia Carvalho
Nursing Education
PechaKucha Versus PowerPoint for Parkinson's Disease Education in Nurses
This study compared the effects of PechaKucha and traditional PowerPoint presentation techniques used for Parkinson's disease education on nurses' knowledge and awareness levels.
- Trial name
- NCT07800312
- Testing
- PechaKucha-Based Parkinson's Disease Education, PowerPoint-Based Parkinson's Disease Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Parkinson's Disease
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease
This proposal seeks to 1) determine whether there are biomarkers associated with Parkinson's disease (PD) susceptibility and/or progression in exosome-proteomes derived from PD patients versus controls, and 2) to determine if…
- Trial name
- NCT01860118
- Where
- United States
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease
Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD
In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and…
- Trial name
- NCT03656796
- Testing
- Treadmill training with auditory cues, Treadmill training without auditory cues
- Where
- Taiwan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson Disease, Essential Tremor
Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation
Individuals experiencing tremors face difficulty performing activities of daily living caused by involuntary oscillation of the muscles in the hands and arms.
- Trial name
- Tremor (NCT05308368)
- Testing
- Ultrasound Imaging, Electromyography, Inertial Measurement Units (IMU)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
SCI - Spinal Cord Injury
Effect of tSCS on Ankle Movement Training in Individuals With SCI
This clinical trial explores the effectiveness of transcutaneous spinal cord stimulation (tSCS), a non-invasive technique, in facilitating spinal circuitry adaptation in individuals with spinal cord injury (SCI).
- Trial name
- NCT06596174
- Testing
- Transcutaneous spinal cord stimulation (tSCS), Short-term Machine-Assisted Ankle Movement Training with tSCS, Long-term Effects of Machine-Assisted Ankle Movement Training with tSCS
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Parkinson Disease, Parkinson
tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease
Implicit motor sequence learning (IMSL) is a form of cognitive function that is known to be directly associated with impaired motor function in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Parkinson, Healthy
- Trial name
- NCT04606979
- Testing
- 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Alzheimer's Disease
Visuospatial Attention, Eye Movements and Instrumental Activities of Daily Living (IADLs) in Alzheimer's Disease
The aim is to understand which components of attentional deployment and selection are impaired in AD during searching in realistic scenes on a computer screen (Experiment 1) and in a natural setting (Experiment 2).The…
- Trial name
- ARVA-MA (NCT02941289)
- Testing
- Performance of everyday objects in realistic scenes
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
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