Clinical trials: Movement Disorder
Parkinson Disease
Action Observation Plus Sonification Therapeutic Protocol
The target of this clinical trial is Freezing of Gait symptom (FoG), and associated falls. The project is aimed to evaluate the effects of an innovative experimental protocol to treat Parkinson (PD) Patients with FoG.
- Trial name
- AOFREEPD (NCT03249155)
- Testing
- AO - plus sonification, CUE - visual and auditory
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Huntington Disease
Preparing for Prevention of Huntington's Disease (PREVENT-HD)
This is a prospective investigation which aims to address key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD).
- Trial name
- PREVENT-HD (NCT04818060)
- Testing
- Clinical Assessments, MRI Scan, Lumber Puncture (LP)
- Where
- United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Parkinson Disease
Progression Follow up of the First-degree Relatives of Patients With REM Sleep Behavior Disorder
REM sleep behavior disorder is a novel and distinct parasomnia characterized by recurrent dream enactment behaviors (DEBs) and polysomnographic features of REM sleep without atonia (RSWA), with typical onset age at early 60's.
- Trial name
- NCT05353959
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Parkinson's Disease
Speech Intelligibility of Patients With P D Compared to First Degree Relatives of P D Patients
This study will examine speech intelligibility of early parkinson's disease (PD) patients, early PD patients and first degree relatives.
- Trial name
- NCT01776879
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Mastication Disorder, Swallowing Disorder
Chewing, Swallowing and Orofacial Motricity in Severe Obese
Background: Obesity is considered an epidemic disease of great repercussion on the world and its prevalence has increased in recent decades.
- Conditions
- Mastication Disorder, Swallowing Disorder, Orofacial Dyskinesia
- Trial name
- NCT05516693
- Testing
- Myofacial muscle training protocol.
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centro Universitário de Anapolis
Renal Impairment, Renal Disease
Study to Assess Adverse Events and the Movement of Oral Venetoclax Tablet Through the Body of Female Participants Aged 18-75 Years With Impaired Renal Function
Renal insufficiency is common in participants with blood cancers. The main objective of this study is to evaluate adverse events and movement of oral venetoclax tablets through the body of female participants with severe normal…
- Trial name
- NCT04810598
- Testing
- Venetoclax
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AbbVie
Brain Neuroimaging Biomarkers in Huntington Disease
Dynamic Neuroimaging Biomarkers in Huntington's Disease
There is no curative treatment available today in Huntington disease (HD) despite the identification of the mutated gene 20 years ago.
- Trial name
- HDeNERGY (NCT02639871)
- Where
- France
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease, Parkinsonism
Advance Care Planning and Care Coordination for People With Parkinson's Disease
Background: People with Parkinson's disease (PD), including parkinsonisms, experience complex motor and non-motor symptoms, which become more hindering in the advanced stages of PD.
- Trial name
- PD_Pal (NCT05954013)
- Testing
- PD_Pal intervention
- Where
- 7 sites in Austria, Estonia and 5 more
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Autism, Cerebral Palsy
Near-infrared Spectroscopy and Electroencephalography to Assess Cortical Activation During Motor Tasks in Infants and Toddlers With and Without Cerebral Palsy
Background: New ways to study the brain as people move include near-infrared spectroscopy (NIRS) and electroencephalography (EEG).
- Trial name
- NCT03434080
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Parkinson's Disease
Effect of Paracetamol on Opicapone Pharmacokinetics in Healthy Volunteers
Single-centre, open-label, randomised, two-way cross-over study consisting of 2 periods separated by a washout period of 14 days or more.
- Trial name
- NCT02305017
- Testing
- BIA 9-1067, Paracetamol
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bial - Portela C S.A.
Dementia, Alzheimer Disease
The Swedish BioFINDER 2 Study
The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g.
- Conditions
- Dementia, Alzheimer Disease, Parkinson Disease, Lewy Body Disease
- Trial name
- BioFINDER2 (NCT03174938)
- Testing
- Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau
- Where
- 2 sites in Sweden
- Volunteers
- 2,950 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Temporomandibular Disorders
Evaluation of Influence of Two Treatment Protocols on Mandibular Movements and Condyle-fossa Relation
The edentulism and use of inadequate dentures, unstable and with teeth worn because long period of usage can lead to an disharmony of the stomatognathic system due to gradual loss of occlusion vertical dimension resulting in…
- Trial name
- NCT02015585
- Testing
- interocclusal appliance, Relining of the complete dentures, Complete denture rehabilitation
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Healthy Aging and Parkinson's Disease
In Vivo Noradrenergic System and Aging
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (here Parkinson's disease) through the use of a newly…
- Trial name
- NA2C-PET-MRI (NCT07569120)
- Testing
- PET/MRI scanning session, Neuropsychological examination, Olfactory screening
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Muscle Weakness
Effect of Sequencing on Outcome Measures
This pilot study will examine the effect of testing order on test outcomes for measures of strength, dynamic balance, and movement quality.
- Trial name
- NCT06445491
- Testing
- Control order, Randomized sequence
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Cerebral Palsy
Motor Imagery Training in Children With Unilateral Cerebral Palsy
Motor imagery (MI) is a promising method to improve more cognitive aspects of motor behaviour, and may, thus, be effective for facilitating motor planning in children with Cerebral Palsy (CP).
- Trial name
- NCT03954808
- Testing
- Motor Imagery Training, Traditional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Malocclusion of Anterior Teeth
Effects of Laser Therapy and Vitamin D Pills on Braces Tooth Movement: A Random Controlled Study
This clinical trial aims to evaluate the efficacy of low-level laser therapy (LLLT) in conjunction with oral vitamin D3 supplementation in accelerating orthodontic tooth movement in adults with crowded mandibular anterior teeth…
- Trial name
- LLLT (NCT07286474)
- Testing
- Cholecalciferol (Vit D3), Low-Level Laser Therapy, Fixed Orthodontic Appliance
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Tourette Syndrome, Tic Disorders
Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement
This study will use electroencephalography (EEG) and electromyography (EMG) to examine how the brain generates tics and controls voluntary movement in patients with Tourette's syndrome and chronic motor tic disorder.
- Trial name
- NCT00056420
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease
Visual Spatial Exploration and Art Therapy Intervention in Patients Diagnosed With Parkinson's Disease
The purpose of this dual phase cross-sectional, controlled and prospective, open label, exploratory study is to determine the general characteristics of visuospatial exploration and its neural substrate in subjects with…
- Trial name
- ExplorArtPD (NCT03178786)
- Testing
- PAT sessions
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Parkinson's Disease
Novel DBS Stimulation Patterns for Treatment of Parkinson's Disease
This is an open-label, non-randomized, proof-of-concept comparison of clinical vs. research stimulation patterns in patients with Parkinson's disease (PD) being treated with Deep Brain Stimulation (DBS) through the Medtronic…
- Trial name
- NCT04799470
- Testing
- Novel DBS stimulation patterns
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Tooth Crowding
Effect of Corticotomy on the Orthodontic Tooth Movement
Orthodontic therapy allows for the treatment of dental malpositions in order to produce an adequate relationship between teeth during occlusion. Conventional orthodontic therapy applies slight forces and moves teeth slowly.
- Trial name
- NCT01630473
- Testing
- Corticotomy, Conventional orthodontics
- Where
- Colombia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
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