Clinical trials: Movement Disorder
Parkinson's Disease
Parkinson's Diseases Susceptibility Genes and Pesticides
Parkinson's disease (PD) occurrence is higher in rural than in urban populations of industrialized countries. Epidemiologic and human tissue studies suggest that pesticides may be responsible for causing dopaminergic cell death…
- Trial name
- NCT00044590
- Where
- United States
- Volunteers
- 1,870 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Parkinson Disease
The Efficacy and Mechanism of SMA+M1 Repetitive Transcranial Magnetic Stimulation on Freezing of Gait in PD
This study is a double-blinded randomized study examining the efficacy of the double-site (M1+SMA) repetitive transcranial magnetic stimulation on Freezing of Gait (FOG) in patients with Parkinson's disease.
- Trial name
- NCT06415682
- Testing
- SMA+M1 Transcranial Magnetic Stimulation, M1 Transcranial Magnetic Stimulation
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
miRNAs Profiling in Parkinson's Disease
microRNAs (miRNAs) regulate fundamental cell processes. Dysregulation of miRNA expression and function is reported in various diseases including cancer, metabolic disorders as well as neurological disorders.
- Trial name
- NCT03466723
- Testing
- biomarker identification in Parkinson disease
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Parkinson Disease
tACS Modulates Speech and Cognitive Impairments in People With PD by Targeting the Medial Frontal Cortex
This clinical trial aims to study whether transcranial alternating current stimulation (tACS) applied to the medial frontal cortex (MFC) can improve speech and cognitive function in people with Parkinson's disease (PD), and to…
- Trial name
- NCT07240272
- Testing
- 6Hz-tACS
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ke Dong, MD
Parkinson Disease, Idiopathic, Freezing of Gait
AID-FOG: Artificial Intelligence-Driven Freezing of Gait Detection in the Home
Freezing of gait (FOG) is a debilitating symptom of Parkinson's disease increases the risk of falling. Despite being a common symptom, it is still difficult to evaluate freezing of gait quickly and accurately.
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Validation, Wearable Sensors
- Trial name
- AID-FOG (NCT07580612)
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Breast Cancer, Pain, Chronic
The Sequelae of Mastectomy and Quadrantectomy Respect to the Reaching Movement in Breast Cancer Survivors
The hypothesis behind our study was that patients after BC surgery, who underwent quadrantectomy or mastectomy, may present a different disability respect to the upper limb on the operated side.
- Conditions
- Breast Cancer, Pain, Chronic, Pain, Postoperative, Mastectomy; Lymphedema
- Trial name
- NCT04145739
- Testing
- Rehabilitation protocol
- Where
- Italy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Parkinson Disease
Prevention of Medical, Social, and Psychosocial Risks Following a Parkinson's Disease Diagnosis: A Pilot Study
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, with a prevalence expected to double by 2040.
- Trial name
- PRIMS-PARK (NCT07578272)
- Testing
- Patient questionnaires, Caregiver questionnaires
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Fragile X Syndrome, Angelman Syndrome
Parent and Infant Inter(X)Action Intervention (PIXI)
The objective is to develop and test, through an iterative process, an intervention to address and support the development of infants with a confirmed diagnosis of a neurogenetic disorder with associated developmental delays or…
- Conditions
- Fragile X Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Dup15Q Syndrome
- Trial name
- NCT03836300
- Testing
- Parent-Infant Inter(X)action Intervention (PIXI)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- RTI International
Parkinson Disease, Dementia
Imaging Studies of Cognitive Impairment in Parkinson s Disease
Background: Parkinson's disease causes slow movements, stiffness, and tremor. It can get worse over time, and in some cases can lead to dementia.
- Trial name
- NCT01862744
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tenosynovitis
Mobilization With Movement Versus Joint-Specific Manipulation in De Quervain's Tenosynovitis
A comparative study on the effectiveness of mobilization with movement (MWM) versus joint-specific manipulation (JSM) in patients with De Quervain's tenosynovitis typically aims to assess how each technique impacts pain relief…
- Trial name
- NCT06918158
- Testing
- Mobilization with Movement, Joint Specific Manipulation
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Developmental Coordination Disorder
Rhythmic Motor Learning in Children With Developmental Coordination Disorders
The importance of play and physical activity include many benefits on positively improving health and well-being, enhancing children's and young people's thinking and performance in school, improving their sleep and enabling…
- Trial name
- EPIC2 (NCT03150784)
- Testing
- EPIC Club
- Where
- 5 sites in United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Oxford Brookes University
Parkinson Disease (PD)
Validation of α-synuclein Modifications in Parkinson's dIsoRder Evolution
Parkinson's disease (PD) presents a complex challenge due to its progressive neurodegenerative nature, affecting various bodily systems.
- Trial name
- VaMPiRE (NCT06941012)
- Testing
- Blood draw for the laboratory assessment
- Where
- 4 sites in Greece, Italy and 2 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Casa di Cura IGEA
Parkinson's Disease
Piloting a Novel, Mobile Cognitive Tracking and Training Tool for Patients With Parkinson's Disease (PD)
The overall goal of this research proposal is to develop an adjunct to standard treatments that 'correct' disrupted neural circuitry in Parkinson's Disease (PD) patients.
- Trial name
- NCT02922530
- Testing
- Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
- Volunteers
- healthy volunteers welcome
- Sponsor
- Posit Science Corporation
Fetal Heart Failure, Fetal Movement Disorder
Tactile Stimulus, Music Play and Virtual Reality Video Watching During Non-Stress Test on Maternal Anxiety and Fetal Parameters
The research was carried out to determine the effects of tactile stimulation, music listening and virtual reality video watched during the non-stress test on maternal anxiety level and fetal parameters.
- Trial name
- NCT05492058
- Testing
- tactile stimulation group, listen music, virtual reality group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Adiyaman University Research Hospital
Parkinson Disease, Freezing of Gait Symptoms in Parkinson Disease
Pedunculopontine Nucleus Transcranial Ultrasound Stimulation as a Treatment of Freezing of Gait in Parkinson's Disease
This study is investigating the use of transcranial ultrasound stimulation (TUS) on the Pedunculopontine nucleus (PPN) in changing freezing of gait in people with Parkinson's disease.
- Trial name
- NCT07695233
- Testing
- Excitatory Stimulation, Inhibitory Stimulation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Robert Chen
Parkinson Disease
Diagnostic Tools for Parkinson's Disease
The study aims to identify genetic variants associated to Parkinson's disease through the analysis of exome-sequencing data of familial cases and controls.
- Trial name
- NCT02403765
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Wilson Disease, D-Penicillamine
Wilson's Disease Treated With D-Penicillamine: Characterization of Skin Damage Secondary to Treatment by Measuring Skin Elasticity
Wilson's disease is a genetic disorder, resulting from an anomaly present on the ATP7B gene located on chromosome 13, causing a progressive accumulation of copper in various organs such as the liver, nervous system and cornea…
- Conditions
- Wilson Disease, D-Penicillamine, Effect of D-penicilline on Cutaneous Elastity of Wilson's Patient
- Trial name
- WILDERME (NCT06945081)
- Testing
- Preparation of forearm molds with SILFLO® silicone
- Where
- 2 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
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