Clinical trials: Movement Disorder
Parkinson's Disease, Major Depressive Disorder
Imaging Depression in Parkinson's Disease
The goal of this observational study is to identify targetable neural substrates of depression in Parkinson's Disease for the first time in people with Parkinson's between the ages of 40 and 80, who are experiencing symptoms of…
- Trial name
- NCT06402955
- Testing
- 11C-UCB-J, ketamine hydrochloride
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Parkinson Disease
The Optimisation of Parkinson's Project
This project aims to gain a deep understanding of the available lay/professional community resources and systems of support for people with, and family carers of people with Parkinson's Disease (PD), healthcare professionals and…
- Trial name
- OPTIMPARK1 (NCT04125485)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Mesial Movement of Teeth
Full Thickness Mucoperiosteal Flap Versus Low Level Laser in Orthodontic Tooth Movement Acceleration
This study aimed to evaluate the effect of using full thickness mucoperiosteal flap (FTMPF) elevation only versus low level laser therapy (LLLT) on acceleration of orthodontic tooth movement.
- Trial name
- NCT04055935
- Testing
- elevation of full thickness mucoperiosteal flap, low level laser therapy
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Interstitial Lung Disease
Assessment of Lung Movement With Computed Tomography (CT)
The purpose of this study is to determine whether patient with ILD have altered lung compliance on chest CT before they have macroscopic structural changes on CT.
- Trial name
- NCT03068091
- Testing
- Chest CT, Pulmonary Function Testing
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Multiple Sclerosis, CVA
Feasability, Validty and Reliability of Inertial Sensors
This study has 3 aimes: 1. To investigate the feasibility of using IMUs (Xsens, MVN Studio) during functional tasks to assess upper limb kinematics in pwMS and stroke survivors.
- Trial name
- NCT03668990
- Testing
- IMUs (Xsens, MVN Studio)
- Where
- 2 sites in Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Migraine
A Study Investigating the Movement of Lu AG09222 Into, Through, and Out of the Body of Healthy Caucasian, Chinese, and Japanese Participants
The main goal of the study is to learn more about how the body absorbs and eliminates Lu AG09222 after a single dose is injected under the skin.
- Trial name
- NCT05304910
- Testing
- Lu AG09222
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD)
Early Stage of Alzheimer's and Parkinson's Diseases, HearIng Relevance (SAPHIR)
The study aims to phenotype hearing in patients with early stage of neurodegenerative disorders to explore the prevalence of various hearing disorders in comparison to a control population.
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Parkinson Disease (PD), Healthy Participants
- Trial name
- SAPHIR (NCT07083089)
- Testing
- Thorough Hearing assessment
- Where
- 4 sites in France
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Cilcare SAS
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cerebral Palsy, Muscle Hypertonia
Hypertonia in Patients With Cerebral Palsy
This study will classify types of hypertonia in patients with cerebral palsy and determine if the classifications are reasonable in relation to the functional task of walking. Hypertonia is an abnormal increase in muscle tension.
- Trial name
- NCT00123708
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Nocturnal Hypokinesia
Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors
Parkinson's disease (PD) is the neurodegenerative disease which is caused by Lewy bodies deposition in central and peripheral nervous system.
- Trial name
- NCT03098368
- Testing
- Rotigotine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Malocclusions, Canine Retraction
Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction
To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison.
- Trial name
- NCT07455656
- Testing
- patients will receive local application of vitamin D3 combined with corticision
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Stroke
tDCS Combined With Constraint Induced Movement Therapy and Role of GABA Activity in Stroke Recovery
The aim of this study is to determine whether noninvasive brain stimulation in form of active transcranial direct current stimulation (tDCS) combined with constraint induced movement therapy (CIMT) offers an additional benefit as…
- Trial name
- NCT01983319
- Testing
- active anodal transcranial Direct Current Stimulation (tDCS), Constraint Induced Movement Therapy (CIMT)
- Where
- Denmark
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Parkinson Disease
The Dutch Parkinson and Cognition Study
Parkinson Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms.
- Trial name
- DUPARC (NCT04180865)
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Parkinson Disease, Ataxia
Rhythmic Entrainment in Bilingual Speakers With Dysarthria
The objectives of this study are to determine i) the effect of rhythmic entrainment of speech with hand gestures and auditory rhythmic cues on intelligibility and speech naturalness in Spanish-accented speakers of English in two…
- Trial name
- NCT03645265
- Testing
- Auditory, Gestures
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Herbert H. Lehman College, City University of New York
Parkinson Disease
neuroQWERTY: a Transparent Patient-centered Outcome Method to Quantify Parkinsonian Motor Signs for Drug Trials
The motor impairment produced by Parkinson's disease (PD) is a significant and debilitating part of the condition. Current methods to evaluate this impairment rely on subjective examinations.
- Trial name
- neuroQWERTY (NCT02522065)
- Where
- 6 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundación de investigación HM
Parkinson Disease
Intelligibility Assessment for Parkinson's Disease
The investigators aim at testing the efficacy of an app to measure sentence intelligibility in noise in speakers with Parkinson's disease and in healthy controls.
- Trial name
- NCT04829006
- Testing
- Understand Me For Life
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Long Island University
Stroke
The Role of Auditory Feedback in Guiding Upper Extremity Movements
Stroke is one of the leading causes of disability, with an estimated prevalence of 50,000 cases per year in Canada. Less than half of stroke patients regain use of their arm and hand.
- Trial name
- NCT02100306
- Testing
- Auditory Feedback 100%, Auditory Feedback 50% alternate
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
PARKINSON DISEASE (Disorder)
The Effect of Long-term Daily Stimulation of the Brain With Pulsed Electromagnetic Fields on Parkinsons Disease
The goal of this clinical trial is to learn to what extent daily stimulation of the brain with transcranial pulsed electromagnetic fields (T-PEMF) works to treat persons with Parkinson's Disease.
- Trial name
- NCT07306104
- Testing
- Transcranial pulsed electromagnetic fields (T-PEMF)
- Where
- 2 sites in Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Parkinson Disease
Parkinson's Disease and Gamma-transcranial Alternating Current Stimulation
Cortical-basal ganglia gamma oscillations are pathologically reduced in Parkinson's disease (PD) and the plasticity of the primary motor cortex (M1) is impaired.
- Trial name
- NCT06297538
- Testing
- gamma transcranial alternating current stimulation (tACS)
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS)
4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug…
- Conditions
- Corticobasal Degeneration (CBD), Corticobasal Syndrome (CBS), Cortical-basal Ganglionic Degeneration (CBGD), Progressive Supranuclear Palsy (PSP)
- Trial name
- 4RTNI-2 (NCT02966145)
- Testing
- Observational Study
- Where
- 8 sites in United States, Canada
- Volunteers
- 293 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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