Clinical trials: Movement Disorder
Parkinson Disease
A Clinical Study Trial of Phenlarmide in China
1. To evaluate the tolerance and safety of FLA tablets in healthy volunteers. 2. To evaluate the pharmacokinetics of FLA tablets in healthy volunteers. 3. Provide basis for dosage setting for follow-up clinical research.
- Trial name
- NCT04164121
- Testing
- Phenlarmide Tablets
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yiling Pharmaceutical Inc.
Parkinson Disease
Visuomotor Control in Parkinson Disease
Visuomotor processing is the ability to integrate visual information into motor plans and movement correction, which is highly required in daily activities such as writing and walking.
- Trial name
- NCT06918938
- Where
- Taiwan
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Knee Osteoarthritis, Total Knee Replacement
Movement Dynamics of Knee Osteoarthritis and Total Knee Replacement
This research aims to explore differences in walking and functional movement mechanics, exercise response, and physical activity between people with osteoarthritis (OA), those who have undergone total joint replacement, and…
- Trial name
- MDOA&TKR (NCT06829433)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Cognitive Dysfunction, Alzheimer Disease
Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults
BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy.
- Conditions
- Cognitive Dysfunction, Alzheimer Disease, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06733714
- Testing
- Transcranial Alternating Current Stimulation, Digital Cognitive Training
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Parkinson Disease
Single Photon Emission Computed Tomography to Study Receptors in Parkinson's Disease
This study will use single photon emission computed tomography, or SPECT (see below), to examine brain nicotine receptors in evaluating the role of a chemical called acetylcholine in memory and other problems in Parkinson's…
- Trial name
- NCT00058721
- Testing
- I-123-5-IA85380
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease
Parkin Mutations and Their Functional Consequences
Parkinson's disease (PD) is the most frequent neurodegenerative disease with a prevalence of 2% over 65 years and because of this high prevalence as the population ages, it is a major problem of public health.
- Trial name
- NCT00136721
- Where
- France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
Non-invasive Detection of Volatile Metabolites in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Currently, a diagnostic test for early PD does not exist.
- Trial name
- PANORAMA (NCT06453226)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Ideomotor Apraxia
Using fMRI to Understand the Roles of Brain Areas for Fine Hand Movements
Ideomotor apraxia, a disorder that affects patients with stroke and a variety of other brain lesions, features disturbed timing, sequence, and spatial organization of skilled movements.
- Trial name
- NCT00063115
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease, Progression, Disease
Neuromelanin MRI: A Progression Marker in Early PD
Prospective observational study to qualify NM-MRI as progression marker in early Parkinson's.
- Trial name
- InsIghtPD (NCT05631158)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Alzheimer Disease, Frontotemporal Degeneration
In Vivo PET of Synaptic Density in Cognitive Disorders
This study will compare the discriminative power of [18F]-SynVesT-1 PET and the standard-of-care [18F]-FDG PET in different cognitive disorders (Alzheimer's disease, Frontotemporal degeneration, dementia with Lewy bodies and…
- Conditions
- Alzheimer Disease, Frontotemporal Degeneration, Dementia With Lewy Bodies, Psychiatric Disorder
- Trial name
- NCT05384353
- Testing
- [18F]-SynVesT-1
- Where
- Belgium
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson's Disease
Speed of Processing Training in Patients With Parkinson's Disease and Healthy Older Adults
The purpose of this prospective, within-subject randomized cross-over design study is to determine if a computer training program (Speed of Processing Training - SOPT) improves safe pedestrian behavior in patients with…
- Trial name
- NCT02929758
- Testing
- Speed of processing training (SOPT)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease, Physical Exercise
Research on the Effect and Mechanism of Aerobic Exercise on PD
This trial is expected to recruit patients with primary Parkinson's disease and give them four consecutive weeks of aerobic exercise to observe its effect on Parkinson's disease and explore its mechanism
- Trial name
- NCT04651140
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Parkinson's Disease
Neuroimaging Studies of Depression in Parkinson's Disease
The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of…
- Trial name
- NCT00518258
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lee Blonder
Fetal Conditions, Fetal Movement Disorder
Does a Relationship Exist Between Fetal Hiccups and Computerised Cardiotocography Parameters?
BACKGROUND: The physiological function of fetal hiccups and its correlation with fetal well-being is unexplored. No previous study examines the correlation between the maternal perception of the fetal hiccups and the antepartum…
- Trial name
- NCT04366076
- Testing
- Fetal heart rate (FHR) monitoring through computerized cardiotocography (cCTG) analysis antepartum
- Where
- Italy
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Parkinson Disease
A Study to Assess Pharmacokinetics (PK) of Preladenant in Participants With Chronic Renal Impairment (CRI) (P06512)
This is a two part study to compare the PK of preladenant administered to participants with CRI to the PK of preladenant administered to healthy participants.
- Trial name
- NCT01323855
- Testing
- Preladenant
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson Disease
Parkinson Disease Telerehabilitation Program (PDTR): a Home-motor Program. A Pilot Study.
Parkinson's disease (PD) leads to multifactorial disabilities with consequent social restrictions, especially in the COVID-19 era.
- Trial name
- NCT05762562
- Testing
- Telerehabilitation with open source platforms
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Parkinson's Disease
Motor Skill Learning in People With Parkinson's Disease
This study will compare brain changes in people with Parkinson's disease with those of normal control subjects while they learn motor skills.
- Trial name
- NCT00396942
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease (PD)
CODY (Co-design for You): An Immersive Technology Tool for Experiencing and Assessing Home Alterations
CODY (co-design for you) is a Virtual Reality (VR) tool and Application Programming Interface (API) which uses an immersive, interactive environment for using, experiencing and co-designing home alterations.
- Trial name
- NCT03961282
- Testing
- Doorway Width Test, Door Frame Color Test
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Florida
Movement Disorders, Muscle Tenderness
Verbal Cueing vs Constraint-Led Approach for Teaching the Kettlebell Swing
The purpose of this study is to determine which method is most effective for teaching the kettlebell swing: verbal cueing, physical constraints, or a combination of the two.
- Trial name
- NCT05560269
- Testing
- Verbal coaching vs. Constraint based coaching
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Parkinson Disease
PET Study of Non-Motor Symptoms of Parkinson Disease
This research plan is focused on neurochemical positron emission tomography (PET) studies of Parkinson disease (PD). PD is the most common neurodegenerative movement disorder, and considerable progress has been made in…
- Trial name
- NCT01565473
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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