Clinical trials: Movement Disorder
Alzheimer's Disease
Visuospatial Attention, Eye Movements and Instrumental Activities of Daily Living (IADLs) in Alzheimer's Disease
The aim is to understand which components of attentional deployment and selection are impaired in AD during searching in realistic scenes on a computer screen (Experiment 1) and in a natural setting (Experiment 2).The…
- Trial name
- ARVA-MA (NCT02941289)
- Testing
- Performance of everyday objects in realistic scenes
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Parkinson Disease, Dyskinesia, Drug-Induced
Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy
This open-label study is designed to assess the long-term safety and tolerability of dipraglurant in PD patients for up to 52 weeks (at doses of 150-300 mg per day) for patients that have completed an Addex sponsored double-blind…
- Conditions
- Parkinson Disease, Dyskinesia, Drug-Induced, Dyskinesias
- Trial name
- NCT05116813
- Testing
- Dipraglurant
- Where
- 7 sites in United States
- Volunteers
- 17 people
- Sponsor
- Addex Pharma S.A.
Parkinson Disease
Light Therapy Intervention in Individuals With Parkinson's Disease
The study looks to investigate the effects that light therapy delivered to the frontal cortex could have on Parkinson's disease related symptoms ( both cognitive and motor).
- Trial name
- NCT06916260
- Testing
- Red Light (PDT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Delaware
Parkinson Disease
Chinese EOPD Registry
The purpose of the Chinese Early-onst Parkinson's disease Registry (CEOPDR) is to develop a database of persons with early-onset Parkinson's disease (EOPD) in China.
- Trial name
- NCT03508960
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Xiangya Hospital of Central South University
Osteoarthritis, Knee, Osteoarthritis, Hip
Helping Osteoarthritis Patients to Walk With NSAID
There is a lack of effective analgesic treatments to help walking patients with painful hip/knee osteoarthritis. Our team therefore imagined a new strategy lying on a multimodal rehabilitation walking program with the help of a…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Chronic Pain
- Trial name
- PERIPATEI (NCT05761015)
- Testing
- therapeutic program including intermittent drug intake and multimodal rehabilitation program
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Clermont-Ferrand
Primary Dysmenorrhea
Immediate Effects of Kinesio Taping in Primary Dysmenorrhea
Primary dysmenorrhea is characterized by recurrent, cramping lower abdominal pain during menstruation and affects approximately 50% to 90% of women.
- Trial name
- NCT06990815
- Testing
- Kinesio Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Okan University
Progressive Supranuclear Palsy (PSP), Healthy Participants
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
This clinical study is being conducted to learn more about two new imaging drugs, called [18F]ABBV-964i and [18F]ABBV-965i, which are designed to help doctors see changes in the brain related to a condition called Progressive…
- Trial name
- NCT07348276
- Testing
- [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Invicro
Parkinson Disease, Voluntary Peak Cough Strength
SpiroGym App-Aided Cough Rehabilitation
The pilot study by Srp et al. (2021) proved that the SpiroGym app was feasible for supporting expiratory muscle strength training (EMST) in Parkinson's disease (PD) patients.
- Conditions
- Parkinson Disease, Voluntary Peak Cough Strength, mHealth
- Trial name
- ESApp PD (NCT06481540)
- Testing
- Expiratory muscle strength training + SpiroGym application, Expiratory muscle strength training
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- General University Hospital, Prague
Stroke
Effects of Electromyography-Triggered Constraint-Induced Movement Cycling Therapy on Patients With Chronic Stroke
The study investigates the potential of Electromyography (EMG)-triggered Constraint-Induced Movement Cycling Therapy (CIMCT) versus General Cycling Training (GCT) to enhance balance, strength, and daily activities in chronic…
- Trial name
- NCT06367140
- Testing
- EMG-triggered CIMCT device, general cycling training
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Sahmyook University
Parkinson Disease, Cognitive Dysfunction
Predictors of Parkinson's Disease Progression
it is a prospective longitudinal observational study, aiming to to identify clinical, and biochemical baseline predictors of motor and non-motor PD progression in sample of Egyptian patients.
- Conditions
- Parkinson Disease, Cognitive Dysfunction, Biomarkers
- Trial name
- PDPROG-EGY (NCT04062279)
- Testing
- serum alpha synuclein autoantibodies, motor and non motor scales
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Parkinson Disease
Core Stability and Parkinson Disease
Patients with Parkinson's Disease frequently present impaired postural control that leads to loss of stability and increased risk of falls.Core system, includes passive structures of the thoracolumbar spine and pelvis that work…
- Trial name
- NCT03580096
- Testing
- Core stability, Standard intervention
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad de Granada
PARKINSON DISEASE (Disorder)
Effectiveness of a Home-Based Exercise Program Supported by Self-Management Education in People With Parkinson Disease
This randomized, assessor-blinded clinical trial evaluates whether a structured self-management education and home exercise program improves balance, walking capacity, fall-related concerns, upper-extremity dexterity, and quality…
- Trial name
- NCT07817862
- Testing
- Self-Management Education and Home Exercise Program, Parkinson Disease Educational Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Istanbul University
Tardive Dyskinesia
Efficacy, Safety, and Tolerability of NBI-1065890 Versus Placebo in Adults With Tardive Dyskinesia
The primary objective of this study is to evaluate the efficacy of NBI-1065890 compared with placebo for the treatment of tardive dyskinesia (TD) in adult participants.
- Trial name
- NCT07365462
- Testing
- NBI-1065890
- Where
- 18 sites in United States
- Volunteers
- 100 people
- Sponsor
- Neurocrine Biosciences
Parkinson Disease, Older People
Tele-Rehabilitation Intervention in Community-Based Healthcare for Patients With Parkinson's Disease (DHEAL-COM-PD)
The study aims to measure the improvement in functional capacity in a group of elderly people suffering from early-stage Parkinson's disease (Hoehn \& Yahr scale 1-3), following a telerehabilitation intervention integrated with…
- Trial name
- DHEAL-COM-PD (NCT06984393)
- Testing
- home tele-rehabilitation, Usual care
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Stroke
Comparative Effects of PNF and mCIMT on Lower Limb Function in Patient With Stroke
Stroke, which is frequently characterized by weakness, poor balance, and decreased mobility that impede independence in everyday activities, has been identified as a major cause of long-term impairment globally.
- Trial name
- NCT07331714
- Testing
- PNF, mCIMT
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Riphah International University
PD - Parkinson's Disease, Dexmedetomidine
Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease
Subthalamic nucleus (STN)-deep brain stimulation (DBS) under general anesthesia has been applied to PD patients who cannot tolerate awake surgery, but general anesthesia will affect the electrical signal in microelectrode…
- Conditions
- PD - Parkinson's Disease, Dexmedetomidine, Desflurane, Deep Brain Stimulation
- Trial name
- CHAMPION (NCT05550714)
- Testing
- general anesthesia, Conscious sedation
- Where
- China
- Volunteers
- 188 people
- Sponsor
- Beijing Tiantan Hospital
Parkinson's Disease.
Effects Of Breath And Stacking-Spirometry Incentive in Patients With Parkinson's Disease
Objective: To evaluate the effects of technical-Breath Stacking (BS) and incentive spirometry (IS) on the volume of the chest immediately after and within thirty minutes after the techniques in patients with Parkinson's disease…
- Trial name
- NCT01932684
- Testing
- Breath-Stacking, Incentive spirometry, 5000 Voldyne ® Sherwood Medical, USA
- Where
- 2 sites in Brazil
- Volunteers
- 15 people
- Sponsor
- Universidade Federal de Pernambuco
Tourette's Disorder, Persistent (Chronic) Motor or Vocal Tic Disorder
Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder
The purpose of this trial is to evaluate the clinical efficacy, 12-month durability, and cost-effectiveness of BIP TIC - a therapist-guided and parent-guided internet-delivered behavioural intervention for children and…
- Trial name
- NCT03916055
- Testing
- Exposure and response prevention (ERP), Education on tics
- Where
- Sweden
- Volunteers
- 221 people
- Sponsor
- Karolinska Institutet
Major Depressive Disorder (MDD), Schizophenia Disorder
Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders
This is a prospective observational study to identify sociodemographic factors that predict mental health outcomes in the European population and provide evidence linking common, modifiable sociodemographic risk factors for…
- Conditions
- Major Depressive Disorder (MDD), Schizophenia Disorder, Bipolar 1 Disorder, Alzheimer Disease
- Trial name
- Synapsing-SD (NCT07239843)
- Where
- Spain
- Volunteers
- 1,310 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Parkinson Disease
Counterfactual Thinking and Decision-making in Parkinson's Disease
The aim of this research is to verify the ability of counterfactual thinking about medical decisions in individuals affected by Parkinson's Disease when compared to healthy individuals.
- Trial name
- CT_PD (NCT05756543)
- Testing
- Counterfactual Inference Test
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano