Clinical trials: Movement Disorders, Functional
Parkinson Disease, Gait Disorder, Sensorimotor
Robotic Gait Rehabilitation in Parkinson's Disease
The purpose of this study is to investigate the implementation of a novel gait rehabilitation stimulus (G-EO System) that could advance current clinical practices.
- Trial name
- NCT05218187
- Testing
- G-EO End-Effector Gait Trainer, Conventional Physical Therapy Treatment
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Indiana University
Functional Neurological Disorder
Role of Functional Neurosurgery in Management of Spasticity
Spasticity can result from a variety of causes in neural axis from which most common are cerebral palsy, strokes, cerebral haemorrhage, multiple sclerosis , traumatic brain injury and spinal cord injury and underlying mechanism…
- Trial name
- NCT05731648
- Testing
- Intrathecal balofen pump
- Volunteers
- 40 people
- Sponsor
- Assiut University
Total Hip Arthroplasty, Osteoarthritis
Improving Rehabilitation Outcomes After Total Hip Arthroplasty
This study plans to learn more about the effects of physical therapy (PT) following a total hip arthroplasty (THA). The purpose of this study is to compare standard of care PT after THA with a physical therapy program…
- Trial name
- NCT02920866
- Testing
- Functional Strength Integration (FSI), Control Group (CON)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- VA Office of Research and Development
Stroke
A Randomized Controlled Trial of Bilateral Movement-based Computer Games Training to Improve Motor Function of Upper Limb and Quality of Life in Sub-acute Stroke Patient
This study aims at investigating whether bilateral movement-based training with computer games could augment motor function of paretic upper limb and improve quality of life in sub-acute stroke patients.
- Trial name
- NCT03618732
- Testing
- Bilateral movement-based computer training, Video-directed conventional training
- Volunteers
- 93 people
- Sponsor
- Shatin Hospital
Kinesiophobia (Fear of Movement)
Kinesiophobia in Patients With Implanted Left Ventricular Assist Devices
The goal of this prospective and cross-sectional observational study is to learn if the presence and changes in kinesiofobia (fear of movement) affect functional capacity levels in heart failure patients who are transplant…
- Trial name
- NCT07394621
- Testing
- Physical Activity Recommandations
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Marmara University
Parkinson's Disease
Effects of Exenatide on Motor Function and the Brain
The purpose of this research study is to investigate how the brain and motor behavior changes Parkinson's Disease (PD) over time in response to Exenatide.
- Trial name
- NCT03456687
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Stroke, Hemiparesis of the Upper Limb Following Stroke
Neurophysiological and Behavioral Effects of Combining Transcranial Direct Current Stimulation (tDCS) and Modified-Constraint Induced Movement Therapy (mCIMT)
This clinical trial aims to evaluate the effect of different types of tDCS modulation with mCIMT in improving affected upper-limb motor function for stroke patients.
- Conditions
- Stroke, Hemiparesis of the Upper Limb Following Stroke, Stroke Rehabilitatiom
- Trial name
- tDCS and mCIMT (NCT06786000)
- Testing
- Anodal tDCS combined with mCIMT, Cathodal tDCS combined with mCIMT, Bihemispheric tDCS combined with mCIMT
- Where
- Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Saud University
Parkinson Disease (PD)
Pilot Deprescribing of Antimuscarinic Overactive Bladder Medications in Parkinson Disease
This is an unblinded, non-randomized National Institute of Health (NIH) Stage I of Behavioral Intervention Development trial. The investigators will enroll 20 subjects with Parkinson disease (PD) for a series of 20 of N-of-1…
- Trial name
- NCT07627529
- Testing
- Overactive bladder antimuscarinic deprescribing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Stroke, Rehabilitation
Rhythmic-Based Training with Immersive Mirror Visual Feedback for Neuro-Rehabilitation
In the proposed study, the investigators assumed that rhythmic-based training with immersive mirror visual feedback will provide a better treatment effects than traditional mirror therapy for the patients with unilateral stroke.
- Conditions
- Stroke, Rehabilitation, Virtual Reality, Mirror Movement Therapy
- Trial name
- NCT06056219
- Testing
- Mirror therapy, Virtual reality-based mirror therapy with rhythmic skill training, Task-oriented training
- Where
- Taiwan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
PARKINSON DISEASE (Disorder)
TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients.
- Trial name
- PD TIS (NCT07480317)
- Testing
- Temporal Interference Stimulation (130 Hz), Temporal Interference Stimulation (40 Hz)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Alzheimer's Disease, Huntington's Disease
A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function
This study is to compare the pharmacokinetics of Dimebon in subjects with severe renal impairment to subjects with normal renal function after oral administration of a single oral 20-mg dose of Dimebon.
- Trial name
- NCT00824590
- Testing
- Dimebon
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Parkinson Disease
Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation
This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the…
- Trial name
- LRRK2 (NCT07642908)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Globus Sensation
Comparing Pregabalin and Placebo in Patients With Persistent Globus Sensation
To evaluate the relative merits, safety and effectiveness of pregabalin in globus patients compared with placebo.
- Trial name
- Lyrica (NCT05432843)
- Testing
- Pregabalin
- Where
- 2 sites in Belgium
- Volunteers
- 90 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Parkinson's Disease (PD), Cognition
Effects of Cognitive Dual-Task on Gait in Parkinson's Disease
The aim of this study is to evaluate gait in individuals diagnosed with PD under tasks involving different cognitive domains, to compare the results with those of age and sex-matched healthy individuals, and to determine which…
- Conditions
- Parkinson's Disease (PD), Cognition, Gait Disorders
- Trial name
- NCT07540325
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gazi University
Parkinson Disease
Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Parkinson's Disease Patients With Hypovitaminosis D
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male Parkinson's disease patients with hypovitaminosis D Main questions it aims to answer are: 1.
- Trial name
- NCT07084597
- Testing
- Vitamin D
- Where
- Bangladesh
- Volunteers
- 15 people
- Sponsor
- Bangladesh Medical University
Parkinson's Disease
The Effect of a Motor-cognitive Rehabilitation on Attention in Parkinsonian Patients
In this study the Investigators explore two questions: if the attentive reaction times differs in parkinsonian patients from health controls and if an intensive, focused and aerobic rehabilitation program (Multidisciplinary…
- Trial name
- NCT02727257
- Testing
- MIRT
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease
Auditory and Vestibular Function in Parkinson's Disease
The aims of this study are to: 1. Evaluate peripheral and central auditory and vestibular function in group of adults with idiopathic PD. 2.
- Trial name
- NCT05034094
- Testing
- VEMP recording
- Volunteers
- 70 people
- Sponsor
- Assiut University
Parkinson Disease
Comparison of Different Non-invasive Electrical Stimulation Protocols to Facilitate Rehabilitation in Parkinson's Disease Subjects With Postural Instability and Gait Disorders
The trial will include 51 adult participants with Parkinson's disease and postural instability and gait disorders (PD-PIGD) and 20 age- and sex-matched healthy controls.
- Trial name
- NCT06868160
- Testing
- Rehabilitation, tDCS, tsDCS (first cycle)
- Where
- Italy
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Photobiomodulation, Dementia With Lewy Bodies
Evaluating How Red-light Therapy Applied to the Head Affects Symptoms, Daily Life, and Brain Activity in People With Dementia With Lewy Bodies
Dementia with Lewy bodies (DLB) is a neurodegenerative disease diagnosed primarily based on the presence of cognitive decline, which may include difficulties with memory, attention, and more.
- Trial name
- LewyLIGHT (NCT07602296)
- Testing
- LUCIOLE CAP
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Schizophrenia and Schizoaffective Disorder
Effects of RAS in SZ
The two main groups of medicated patients with schizophrenia (SZ) are those receiving second-generation antipsychotics and those receiving first-generation antipsychotics.
- Trial name
- NCT07086040
- Testing
- RAS incorporated in upper-limb movement training, Upper-limb movement training
- Where
- Taiwan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shu-Mei Wang