Clinical trials: Movement Disorders, Functional
Parkinson Disease, Parkinsonism
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies.
- Trial name
- NCT07674264
- Testing
- Acute intermittent hypercapnic hypoxia (AIHH), Acute intermittent hypercapnic normoxia (AIHN)
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Florida
Conversion Disorder
Metacognitive Therapy and Neuro-physiotherapy as a Treatment for Functional Movement Disorders
Patients with functional movement disorders (FMD) present with abnormal movements incompatible with symptoms of well-defined neurological disorders and are not associated with structural abnormality of the nervous system.
- Trial name
- ReMAP-FMD (NCT05323344)
- Testing
- Neuro-physiotherapy, Combination of metacognitive behavioral therapy and Neuro-physiotherapy
- Where
- 2 sites in Germany
- Volunteers
- 46 people
- Sponsor
- University Hospital Schleswig-Holstein
Functional Neurological Disorder
Investigation of Patients Presenting With Acute Functional Neurological Symptoms
Retrospective Single-center Analysis of Patients Presenting With Acute Neurological Symptoms, Aiming to Characterize the Frequency, Clinical Features, Diagnostic Pathways, and Healthcare Utilization of Patients with Functional…
- Trial name
- FONDA (NCT07538414)
- Testing
- collection of patient data
- Where
- Switzerland
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Exercise, Parkinson Disease
Comparing the Effects of Instability Resistance Training Versus Aerobic Training on Cognitive and Motor Improvements Found in Parkinson's Disease Participants
This study will be looking at the effects that instability resistance training and aerobic training, individually, have on the improvement of various motor and cognitive impairments present in individuals with Parkinson' disease.
- Trial name
- NCT03711955
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Healthy, Epilepsy
Bridging Gaps in the Neuroimaging Puzzle: New Ways to Image Brain Anatomy and Function in Health and Disease Using Electroencephalography and 7 Tesla Magnetic Resonance Imaging
The human brain presents outstanding challenges to science and medicine. Brain function and structure span broad spatial scales (from single neurons to brain-wide networks) as well as temporal scales (from milliseconds to years).
- Conditions
- Healthy, Epilepsy, Psychosis, Essential Tremor
- Trial name
- NCT05769933
- Testing
- Simultaneous EEG-fMRI at 7 Tesla, Structural MRI at 7 Tesla
- Where
- Switzerland
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Developpement
Parkinson Disease, Mitochondrial
Measures of Mitochondria Dysfunction in PD
This study evaluates metabolic and functional parameters in the skeletal muscle of Parkinson's disease patients for comparison to a set of healthy age-matched controls.
- Trial name
- NCT04300608
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Fear, Movement Disorder, Functional
Surgery and Functionality in Older Adults
When the literature is examined, it has not been found that the use of massage applications in relation to the functional level of individuals who have undergone abdominal surgery.
- Conditions
- Fear, Movement Disorder, Functional, Kinesiophobia, Surgery
- Trial name
- SFO (NCT05534490)
- Testing
- therapatic Foot massaje (sweden technic)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- University of Yalova
Cerebral Palsy, Hemiplegia
Effect of Baby-CIMT in Infants Younger Than 12 Months
A randomized control trial investigating if an early intervention program of modified Constraint Induced Movement Therapy for babies, Baby-CIMT, performed before 12 months of age will improve hand function in children with risk…
- Conditions
- Cerebral Palsy, Hemiplegia, Children
- Trial name
- B-CIMT (NCT01864811)
- Testing
- Baby-CIMT, Baby-Massage
- Where
- Sweden
- Volunteers
- 35 people
- Sponsor
- Karolinska Institutet
Parkinson's Disease
Visual Function During Gait in Parkinson's Disease: Impact of Cognition and Response to Visual Cues
Parkinson's disease (PD) is associated with problems of gait such as veering, difficulty turning, an inability to perceive doorways or obstacles, and negotiate uneven terrain.
- Trial name
- NCT02610634
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Parkinson Disease
Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative condition characterized by classic motor symptoms, such as bradykinesia, rigidity, resting tremor, and postural instability, which directly compromise the…
- Trial name
- NCT07567599
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
PARKINSON DISEASE (Disorder), Parkinson Disease
Effect of Repetitive Bihemispheric Anodal Transcranial Direct Current Stimulation on Motor Function of Patients With Parkinson's Disease
Dopaminergic medications and Deep Brain Stimulation (DBS) are the current standards interventions for Parkinson's Disease. Pharmacotherapy with dopaminergic drugs leads to partial improvement in motor functions of patients.
- Trial name
- NCT07395531
- Testing
- Transcranial Direct Current Stimulation
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Dr. Ram Manohar Lohia Hospital
Hyperthermia, Chronic Primary Pain
Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain
This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the…
- Conditions
- Hyperthermia, Chronic Primary Pain, Widespread Pain, Muscular Disease
- Trial name
- HYPPRI-1 (NCT07101978)
- Testing
- serial whole body hyperthermia
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
REM Sleep Behavior Disorder, Parkinson s Disease
Ginger-PD: Ginger as a Modifier of Ghrelin Levels and Gut Function in Parkinson's Disease
This study will test whether taking ginger supplements can increase ghrelin, a hunger hormone that is decreased in the blood of people with Parkinson's disease (PD) and REM Sleep Behaviour disorder (RBD).
- Trial name
- Ginger-PD (NCT07882108)
- Testing
- Ginger
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Parkinson Disease
Human Aging and in Vivo Noradrenergic System
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (Parkinson's disease) through the use of a newly…
- Trial name
- NA_PET_MRI (NCT03942289)
- Testing
- The role of the noradrenergic system across the life span (Healthy Subjects), The role of the noradrenergic system across the life span (Parkinson's Disease Subjects)
- Where
- France
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Neurologic Diseases, Arthropathy of Knee
Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Devices in Neuromotor Rehabilitation
The implementation of virtual reality (VR) and robotic devices in neuromotor rehabilitation has so far provided promising evidence in terms of efficacy throughout different clinical populations.
- Conditions
- Neurologic Diseases, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT05399043
- Testing
- Multidisciplinary Conventional Neuromotor Rehabilitation, Technology-based Rehabilitation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Stroke, Muscle Spasticity
Upper-limb Active Function and Botulinum Toxin A
This study in an observational, prospective and longitudinal study. The aim of the study is to evaluate the effect of botulinum toxin type A (BTX) injections into the elbow flexors on the reduction of spastic co-contractions…
- Conditions
- Stroke, Muscle Spasticity, Upper Extremity Paralysis
- Trial name
- ULAFBoT-Stroke (NCT03783572)
- Testing
- Clinical evaluation, Clinical evaluation and Instrumental evaluation
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Parkinson Disease
Adaptive Deep Brain Stimulation to Improve Motor and Gait Functions in Parkinson's Disease
This is a single-center phase I clinical study aiming to improve gait functions in patients with Parkinson's disease (PD) by using adaptive neurostimulation to the pallidum.
- Trial name
- NCT04675398
- Testing
- Summit RC+S
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Doris Wang, MD, PhD
Constipation
A Study to Evaluate the Effects of a Natural Supplement in Adults With Chronic Functional Constipation
Constipation is common in the general population, especially in women and in the elderly. Hard stool is a complaint often associated with constipation, which suggests that stool softening would provide a major benefit in the…
- Trial name
- NCT02073006
- Testing
- Natural Fibre Supplement
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
PARKINSON DISEASE (Disorder), Parkinson s Disease
Effects of Accelerated rTMS On Motor and Cognitive Function in Parkinson's Disease
Parkinson's disease (PD) is a brain disorder that causes progressive problems with movement, such as slowness, stiffness, tremor, and difficulty walking. Many people with PD also develop problems with thinking and memory.
- Trial name
- NCT07554833
- Testing
- TMS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- San Francisco Neurology and Sleep Center
Movement Disorders
Effects of Lymph Drainage on Patients With Axillary Web Syndrome
Effects of a physical therapy program combined with manual lymphatic drainage on shoulder pain and function, quality of life, lymphedema incidence in breast cancer patients with axillary web syndrome following axillary…
- Trial name
- NCT06438848
- Testing
- Physical therapy program, Physical therapy program with lymphedema drainage
- Volunteers
- 34 people
- Sponsor
- Taif University