Clinical trials: Multicenter Observational Study
Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD)
Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.
The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation…
- Conditions
- Juvenile Idiopathic Arthritis (JIA), Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- DIETA-MICIREUM (NCT06862843)
- Testing
- Collecting questionnaires and biological samples
- Where
- 4 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meyer Children's Hospital IRCCS
Sepsis, Acute Kidney Injury Due to Sepsis
Microbiome and Enteric Signatures in Sepsis-associated Hepatorenal Injury
Sepsis is a major cause of morbidity and mortality in intensive care units. Sepsis-associated liver injury (SALI) and sepsis-associated acute kidney injury (S-AKI) are common complications associated with adverse clinical…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Gastrointestinal Microbiome, Sepsis-Associated Liver Injury
- Trial name
- MESH (NCT07735182)
- Where
- 6 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Neurological Diseases or Conditions, Healthy Participants
GEL & MEDication Dysphagia
This research project examines the prevalence of medication-related dysphagia in patients with dysphagia-associated diseases. Its primary aim is to assess how frequently swallowing difficulties occur during medication intake and…
- Trial name
- GELMED (NCT07254663)
- Testing
- medication swallowing
- Where
- 3 sites in Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Stroke
Guideline-recommended Basic Parameter Adherence in Neurocritical Care Patients
The aim of the planned study project is to assess the current situation regarding the treatment of patients with severe stroke at the neuro-critical care unit.
- Trial name
- NORMONICU (NCT06367543)
- Testing
- Time in therapeutic range of vital parameters
- Where
- Germany
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Multiple Myeloma
A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients
This study assesses the impact of cannabis (also commonly called marijuana, weed, or THC) use on quality of life among patients with multiple myeloma who are receiving chemotherapy.
- Trial name
- NCT07225738
- Testing
- Non-Interventional Study
- Where
- 11 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Dermatitis, Atopic
A Study to Learn About Abrocitinib in Adult Patients With Moderate to Severe Atopic Dermatitis
The purpose of this non-interventional observational study is to learn about the safety and effects of the medicinal product (called Abrocitinib) for the potential treatment of moderate to severe atopic dermatitis (AD).
- Trial name
- NCT05250115
- Where
- 38 sites in Germany
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Pfizer
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates (BANON)
Validation of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies and a preliminary human study.
- Trial name
- NCT03357250
- Where
- 11 sites in Germany
- Volunteers
- 553 people, healthy volunteers welcome
- Sponsor
- Life Science Inkubator
Aorta Disease, Aorta Aneurysm
Assess Abdominal Aortic Diameter in Females
Female subjects aged 50 years or older will be enrolled. Biometric data (measurements) of the aorta and iliac vessels, demographic data, pathophysiological history, and data relating to menarche, pregnancy/infertility, and…
- Trial name
- AFRODITE (NCT07487961)
- Where
- Italy
- Volunteers
- 652 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders
Evaluation of Two Cell-based Assays for Diagnosing MOG-IgG Associated Disorders
Anti-myelin oligodendrocyte glycoprotein-IgG-associated disorders (MOGAD) is a rare inflammatory autoimmune disease. In addition, since the international MOGAD group proposed live-cell based assays for MOGAD diagnosis in 2023…
- Trial name
- NCT06617962
- Testing
- CBA method of live cells and fixed cells
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Diabetes
Diabetes Multicenter Observational Study (DIAMOND-1-)
The purpose of this study is to examine whether pump treatment combined with the use of continuous glucose monitoring system is a mena to normalize glycaemic control.
- Trial name
- DIAMOND-1 (NCT01369823)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medtronic Hellas Medical Devices ΑEE
Sepsis, Acute Infection
A Multicenter Prospective Observational Study to Derive and Verify the Performance of a Host-response Based Diagnostic Tool for Early Detection of Severe Infections.
The study is a multi-center, prospective, observational clinical study enrolling patients from at least 3 medical centers. Study population will include patients over the age of 18 years.
- Trial name
- NCT06665542
- Where
- 8 sites in United States, Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Haemophilia
Extended Half-Life (EHL) Clotting Factor for Improving the Musculoskeletal Health of Patients With Hemophilia
Background. Hemophiliac arthropathy is the main long-term physical damage in patients with hemophilia, causing disability and functional limitations. Objective.
- Trial name
- NCT03914209
- Testing
- EHL clotting factor
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Investigación en Hemofilia y Fisioterapia
Healthy Aging, Nutritional Status
OPTIPROT, Targeted Precision Nutrition for Protein Needs in Ageing
This multicenter, cross-sectional observational study aims to use precision nutrition tools to identify metabolic clusters in adults aged 50-75 years, enabling tailored nutritional and protein recommendations based on specific…
- Conditions
- Healthy Aging, Nutritional Status, Dietary Protein, Muscle Weakness
- Trial name
- OPTIPROT (NCT07436936)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Conduction System Pacing
Long-term Outcomes of Conduction System Pacing: a National Multicenter Observational Study - NORMAND'HIS / STIMU'HIS
This prospective multicenter registry will evaluate the long-term electrical, echocardiographic, and clinical outcomes of conduction system pacing (CSP).
- Trial name
- STIMU'HIS (NCT06088927)
- Testing
- Conduction system pacing
- Where
- 10 sites in France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Inclined Atrophy of the Distal Mandible, Socket Like Atrophy of the Aesthetic Zone
PEERS Multicenter Osseospeed TM TX Profile Implant: German Astra Soft Tissue (GAST) Maintenance Study
The open, prospective, non-controlled observational study is designed to provide information on the short-, medium- and long-term clinical performance of the Astra Tech OsseospeedTM implant surface in combination with a special…
- Trial name
- GAST (NCT01400321)
- Where
- 28 sites in Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Gastric Cancer, Precancerous Lesion of Digestive Tract
The Role of Extracellular DNA (ecDNA) in the Occurrence and Development of Gastric
ECDNA is almost non-existent in normal cells, but exists in nearly half of human cancer cells, indicating that studying such abnormal DNA is of great significance for our understanding of tumor formation and evolution.
- Conditions
- Gastric Cancer, Precancerous Lesion of Digestive Tract, Extrachromosomal DNA
- Trial name
- NCT05956847
- Testing
- gastroscopy
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Antiphospholipid (aPL)-Positive, Rheumatic Arthritis
MENA/Levant Epidemiological, Registry of Immunological & Clinical Traits (MERIT)
The primary objective of this multicenter observational registry is to characterize the clinical, epidemiological, and biological profiles of individuals of Middle Eastern, North African, and Levantine ancestry, including…
- Conditions
- Antiphospholipid (aPL)-Positive, Rheumatic Arthritis, Celiac Disease, Focal Segmental Glomerulosclerosis (FSGS)
- Trial name
- MERIT (NCT07892651)
- Where
- Jordan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Axiom Bioregistry
Cancer, Solid Tumor
Characterization of Methylation Patterns in Cancer and Non-Cancer cfDNA
Nucleix EpiCheck® tests analyzes the methylation pattern in a panel of DNA methylation biomarkers and determines whether this pattern is consistent with cancer under test or with non-cancer tissue.
- Conditions
- Cancer, Solid Tumor, Hematologic Neoplasms
- Trial name
- NCT04264767
- Testing
- Blood collection
- Where
- 3 sites in United States, Israel
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Nucleix Ltd.
Prevention of Vitamin Deficiency During and/or Before Pregnancy
A Study to Gather Information About the Progress and Outcomes of Pregnancy in Women Using Various Vitamin Support Plans Before and During Pregnancy
This is an observational study in which data from the participants who will be taking different vitamin supplementation regimes before and during pregnancy.
- Trial name
- NCT05062044
- Testing
- Multivitamins (Elevit, BAY987808), Multivitamins (Elevit, BAY2906300), Multivitamins (Elevit, BAY987386)
- Where
- 3 sites in Kazakhstan, Russia and 1 more
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Bayer