Clinical trials: Multiple Pregnancy
Breast Carcinoma, Cervical Carcinoma
The Ohio State University (OSU) SCREEN Community Program
This clinical trial develops and tests how well a multi-level intervention (MLI), The Ohio State University (OSU) SCREEN Community Program, works to increase screening and follow-up for breast, cervical and colorectal (CRC)…
- Conditions
- Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma
- Trial name
- NCT06666192
- Testing
- Cancer Screening, Discussion, Educational Activity
- Where
- United States
- Volunteers
- 2,067 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cesarean Delivery, Postpartum Hemorrhage (PPH)
Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery
The goal of this clinical trial is to learn whether applying topical tranexamic acid (TXA) directly to the uterine incision during cesarean delivery can reduce surgical bleeding compared to placebo.
- Conditions
- Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss, Hemostasis
- Trial name
- NCT07362992
- Testing
- Tranexamic Acid (Topical)
- Where
- 4 sites in Israel
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Chronic Kidney Failure, Chronic Kidney Disease stage3
Pathophysiological Characterization of the Neuromuscular Function of a Population With Multiple Comorbidities Suffering From Chronic Renal Failure in Pre-dialysis.
The evolution of chronic kidney disease (CKD) causes a systemic upheaval on the body and a deep fatigue is very often described by patients (50-70% of the patients) even before the start of dialysis (pre-dialysis).
- Conditions
- Chronic Kidney Failure, Chronic Kidney Disease stage3, Chronic Kidney Disease, Stage 4 (Severe), Chronic Kidney Disease Stage 5
- Trial name
- PIONNIER (NCT03998917)
- Testing
- Discrimination of neuromuscular alterations protocol
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier le Mans
Polycystic Kidney Disease
Early PKD Observational Cohort Study
This observational study will collect blood and urine and clinical information from individuals with early-stages of polycystic kidney disease (PKD), their unaffected siblings and normal volunteers to create a biobank, also…
- Trial name
- EPOC (NCT02936791)
- Where
- 3 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
End Stage Renal Disease
Neuroimaging and End Stage Renal Disease
Brain impairment is one of the common complications of end-stage renal disease (ESRD). The patients always present with various cerebrovascular diseases, cognitive impairment and sensorimotor abnormalities, with morbidity over…
- Trial name
- NESRD (NCT03961724)
- Testing
- magnetic resonance image (MRI)
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Healthy Pregnant Women
Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes
The aim of the study is to compare the effects of conventional Ultra High Temperature (UHT) milk containing both A1 and A2 type β-caseins (CON) with a2 UHT Milk containing A2 type β-casein only (A1PF) on inflammation, tolerance…
- Trial name
- NCT06980376
- Testing
- a2 UHT milk, Conventional UHT Milk
- Where
- 6 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Nutrient Deficiency
Antenatal Multiple Micronutrient Supplementation (MMS) in Indonesia
The objective of this research is to understand how antenatal multiple micronutrient supplements (MMS) can be effectively implemented and scaled within the Indonesian national health system context to support improved maternal…
- Trial name
- NCT06225791
- Testing
- MMS (90x2) + BCC or expanded BCC, MMS (180x1) + BCC or expanded BCC
- Where
- Indonesia
- Volunteers
- 5,384 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Frailty Syndrome
SHIP-AGE: Frailty, Renal Function, and Multi-component Primary Care in Rural Mecklenburg-Western Pomerania
Chronic kidney disease (CKD) is a leading risk factor for cardiovascular and all-cause mortality among the elderly. Mecklenburg-Western Pomerania has the largest prevalence of CKD in Germany and Europe.
- Trial name
- MV-FIT (NCT05962203)
- Testing
- Multi-factorial geriatric assessment, monitoring & management systems
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Urinary Tract Infections (UTIs)
Evaluation of the Effectiveness and Safety of a Vaginal Gel for Prevention of Recurrent Urinary Tract Infections
Urinary Tract Infections (UTIs) are among the most common bacterial infections. Although they are typically treated effectively with antibiotics, recurrence is a frequent and troublesome issue.
- Trial name
- UTI (NCT07233473)
- Testing
- Multi-Gyn UT Protect gel
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Karo Pharma AB
Contraception
Maintaining Intrauterine Devices (IUDs) in Teens (MINT): A Randomization Trial
This is a pilot study to determine the feasibility for a randomized controlled trial of two forms of intrauterine contraception: the Levonorgestrel intrauterine system (LNG-IUS) and the Copper T 380A.
- Trial name
- MINT (NCT00653159)
- Testing
- Levonorgestrel-releasing intrauterine device (LNG-IUS), Copper T380A intrauterine device (CuT380A)
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Preterm Birth
Prediction of Spontaneous Preterm Birth by Cervical Elastogram
Background: Preterm birth is the leading cause of perinatal morbidity and mortality in multiple pregnancies. The medical and educational expenditure and lost productivity associated with preterm birth is very high.
- Trial name
- NCT03601195
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Renal Impairment
A Study to Investigate the Effect of Renal Function and Hemodialysis on the Pharmacokinetics (PK) of RO7079901
This is a multi-center, non-randomized, open-label, two-part study to investigate the effect of renal function and hemodialysis on PK of RO7079901.
- Trial name
- NCT02975388
- Testing
- RO7079901
- Where
- 5 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Adherence, Pregnancy
Evaluation of an Intervention for Optimizing Pregnant Women's Adherence to Maternal Multiple Micronutrients Supplements
In collaboration with the Federal Government of Nigeria and Bauchi State, Nutrition International (NI) conducted a three-year implementation research study to assess whether adherence solutions - developed through a…
- Trial name
- NCT07644780
- Testing
- Implementation Approaches
- Where
- 3 sites in Nigeria
- Volunteers
- 2,601 people, healthy volunteers welcome
- Sponsor
- Nutrition International
Pregnancy Related
Multiple Micronutrient Supplementation (MMS) vs IFA Acceptability Crossover Trial
This is an open-label individually randomized mixed methods cross-over trial to assess acceptability, preference, and side effects of IFA formulations with 60 mg of iron to MMS formulations with 60 mg of iron.
- Trial name
- MIFA-ACT (NCT06069856)
- Testing
- Iron Folic Acid Tablets with 60 mg of iron, Multiple Micronutrient Supplements with 60 mg of elemental iron
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- George Washington University
Herpes Simplex
A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital Herpes
The purpose of this first-time-in-human (FTiH) study is to evaluate the reactogenicity, safety, immune response, and efficacy of an investigational herpes simplex virus (HSV)-targeted immunotherapy (TI).
- Trial name
- NCT05298254
- Testing
- Non-adjuvanted HSV formulation 1, Non-adjuvanted HSV formulation 2, Non-adjuvanted HSV formulation 3
- Where
- 30 sites in United States, Australia and 6 more
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Intrauterine Adhesion
Investigating the Association Between Diagnostic and Therapeutic Management Models and Prognosis of Intrauterine Adhesions Based on a Large-Scale Prospective Cohort Study
This research plan aims to explore a new diagnosis and treatment management model for intrauterine adhesions and verify its efficacy and feasibility through a multicenter real-world study.
- Trial name
- NCT07421908
- Testing
- Transcervical resection of adhesion, Uterine cavity stent, Traditional Chinese medicine for tonifying the kidney
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Pregnant Women Requiring Amniocentesis
Prenatal Screening for Imprinting Anomalies Implicated in Beckwith Wiedemann and Silver Russell Syndromes
Losses of imprinting are involved in various syndromes. Those occurring in the 11p15 region lead to Beckwith-Wiedemann and Silver-Russell Syndromes.
- Trial name
- DASIRUWIBE (NCT01842659)
- Testing
- Methylation Index
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Transplantation, Urinary Calculi
Evaluation of Kidney Function by Multi-modal Magnetic Resonance Imaging and Spectroscopy
Multimodal functional magnetic resonance (MR) methods, including MR diffusion, Blood-Oxygenation Level Dependent (BOLD) imaging and MR spectroscopy may provide complementary information about the functional status of a kidney.
- Trial name
- NCT00575432
- Testing
- diffusion MRI, BOLD MRI, Clinical Outcome
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Kidney Disease
A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney Disease
This is a study where a new drug, called GSK4771261 is being tested. Neither the study doctors, study staff or participants will be aware of what treatment is being given.
- Trial name
- NCT06734234
- Testing
- GSK4771261
- Where
- 23 sites in United States, Belgium and 6 more
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline