Clinical trials: Multiple Trauma/Injuries
Brain Injuries, Brain Edema
Non-contact DCS-Speckle Multi-parameter Imaging for Neurological Diseases
This study aims to evaluate brain injuries and brain edema with non-contact DCS-Speckle multi-parameter imager.
- Conditions
- Brain Injuries, Brain Edema, Optical Imaging
- Trial name
- NCT04623307
- Testing
- Non-contact DCS-Speckle multi-parameter imaging
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ting Li
Fracture, Bone Fracture
AI Assisted Detection of Fractures on X-Rays (FRACT-AI)
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Fracture, Bone Fracture, Dislocation, Fracture Multiple
- Trial name
- FRACT-AI (NCT06130397)
- Testing
- Cases reading, Ground truthing
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis
Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction
The purpose of this study is to provide profound insight into the supraspinal neuronal mechanisms and networks responsible for lower urinary tract (LUT) control and to verify, amend or adjust neuronal circuitry models established…
- Conditions
- Neurogenic Lower Urinary Tract Dysfunction, Multiple Sclerosis, Overactive Bladder, Spinal Cord Injury
- Trial name
- NCT01768910
- Testing
- fMRI, bladder filling, bladder cooling
- Where
- 2 sites in Switzerland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Pressure Ulcer, Pressure Injury
Comparison of Static Air Support Devices (Repose®) and Alternating-Pressure Devices in the Prevention of Pressure Ulcers
Maintaining and improving skin health are major goals in acute and long-term care. Patients at the extremes of age, the critically ill, medically compromised and those with immobility are at risk for developing several skin…
- Conditions
- Pressure Ulcer, Pressure Injury, Pressure Sore, Bed Sore
- Trial name
- NCT03597750
- Testing
- Repose®
- Where
- 26 sites in Belgium
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University Ghent
Patient Reported Outcome Measures, Recovery of Function
FIT Study (Functional Outcomes In Trauma Study)
Why? There is not much information in the UK on how well patients who sustain major trauma function afterwards. Major trauma is defined as significant injuries with a calculated 'injury severity score' (ISS) over 15.
- Conditions
- Patient Reported Outcome Measures, Recovery of Function, Rehabilitation, Disability Evaluation
- Trial name
- NCT04074382
- Testing
- Online Questionnaires, Qualitative Interviews
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Knee Injuries
Non- vs Partial Controlled Weightbearing After Multiple Knee Ligament Reconstruction
This is a prospective randomized controlled trial with the purpose to determine if patients undergoing isolated posterior cruciate ligament (PCL) reconstruction, or isolated medial collateral ligament (MCL) reconstruction, or…
- Trial name
- NCT05073276
- Testing
- Physical Therapy
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Twin Cities Orthopedics
Ankle Fractures, Splints
Post Operative Ankle Splint Study - Prospective Multi Center Randomized Controlled Trial
Background: Ankle fractures are some of the most common orthopedic presentations, however, controversy in their management and their post-operative rehabilitation protocols exist.
- Trial name
- PASS (NCT04796168)
- Testing
- Splinting (plaster of paris)
- Where
- Kuwait
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kuwait Institute for Medical Specialization
Healthy, Neurodegenerative Disease
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in brain research.
- Trial name
- BHR (NCT02402426)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Kidney Diseases, Kidney Injury
Study of MB-102 (Relmapirazin) and the Use of the MediBeacon® Transdermal GFR Measurement System Using the TGFR Reusable Sensor With Disposable Adhesive Ring
The goal of this clinical trial was to compare transdermal glomerular filtration rate (tGFR) to plasma-derived indexed GFR (nGFR) using MB-102 (relmapirazin) as the fluorescent compound.
- Conditions
- Kidney Diseases, Kidney Injury, Kidney Failure
- Trial name
- NCT05777174
- Testing
- MB-102, MediBeacon Transdermal Glomerular Filtration Rate Measurement System (TGFR)
- Where
- 5 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- MediBeacon
Infant, Newborn, Infant, Low Birth Weight
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
This pilot study is a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following repeated doses of…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-2 (NCT01030575)
- Testing
- Inositol lower volume, Inositol mid-level volume, Inositol high volume
- Where
- 17 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Spinal Cord Injury
A Phase I Safety Study of NVG-291 in Healthy Adults
This is a randomized, triple-blind (subjects, Investigators, and Sponsor blinded), placebo-controlled Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) study to evaluate the safety and tolerability of NVG-291…
- Trial name
- NCT05308953
- Testing
- NVG-291
- Where
- Australia
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- NervGen Pharma
Chronic Pain Due to Injury
Why Does Acute Post Whiplash Injury Pain Transform Into Chronic Pain?
Why does acute post whiplash injury pain transform into chronic pain? Multi-modal assessment of risk factors and predictors of pain chronification
- Trial name
- NCT02560675
- Where
- Israel
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Upper Limb Amputation Below Elbow (Injury)
Assessment of Gesture Accuracy of a Prosthesis Control System
The study is evaluating the performance of prosthesis control system, referred to as Phantom X, in able bodied individuals and individuals with upper limb amputation at the forearm level.
- Trial name
- ASCENT (NCT06446037)
- Testing
- Non-invasive EMG band instrumentation
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Phantom Neuro Inc.
Heat Stress, Physiological Stress
Physiological Strain in Older Adults During a Simulated Heat Wave
A recent report showed that maintaining indoor temperature at or below 26°C safeguards older, heat vulnerable adults against potentially dangerous increases in thermal and cardiovascular strain during an extreme heat event (PMID…
- Trial name
- NCT06633302
- Testing
- Simulated multi-day heatwave exposure
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stroke, Early Waking
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs.
- Conditions
- Heat Stroke, Early Waking, MODS, Proteinosis
- Trial name
- NCT05155358
- Testing
- Peripheral blood test
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Pain, Traumatic Brain Injury
The NRC Dataset. Developing a Minimum Dataset for Multidisciplinary Rehabilitation: a Modified E-Delphi Study
Several rehabilitation datasets are presently in use for specific patient groups in England. The 'National Clinical Audit of Specialist Rehabilitation for patients with complex needs following major injury' (NCASRI) evaluated…
- Conditions
- Pain, Traumatic Brain Injury, Major Trauma, Multiple Sclerosis
- Trial name
- NCT06726135
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ThomasCorbett
Non Ruptured Tendon Injuries, Tendinopathy
Tissue Repair Device (VergenixTM STR) in Patients With Epicondylitis (Tennis Elbow)
The VergenixTM STR device is intended for the repair of non ruptured tendon injuries (Tendinopathy).
- Trial name
- CP-STR-01 (NCT02309307)
- Testing
- Tissue Repair Device (VergenixTM STR)
- Where
- 3 sites in Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Collplant
Traumatic Brain Injury
A Study to Test the SENSE Device in Military-Age Patients With Traumatic Brain Injury
The study population will consist of 3 mutually-exclusive sets of patients and subjects: TBI patients with intracranial bleeding TBI patients without intracranial bleeding Control subjects with normal brain health.
- Trial name
- Sense-005 (NCT05155800)
- Testing
- SDx3
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sense Diagnostics, LLC
Multiple Sclerosis, Cognitive Impairment
Early Cognitive Impairment in Multiple Sclerosis
Cognitive impairment is one of the symptoms of Multiple Sclerosis (MS), and it may occur during the first years of the disease. It usually affects attention, information processing speed and short term memory.
- Trial name
- CogniSEP (NCT01157728)
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thyroidectomy
RECURRENT LARYNGEAL INJURY WHILE USING LIGASURE Versus CONVENTIONAL KNOT TYING IN TOTAL THYROIDECTOMY
To compare the frequency of recurrent laryngeal injury during total thyroidectomy when utilizing the LigaSure technique against conventional knot tying.
- Trial name
- NCT07522983
- Testing
- tie and knot, Ligasure
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gulab Devi Hospital