Clinical trials: Muscle Disorders
Mitochondrial Respiratory Chain Deficiencies
Abdominal Adiposity and Muscle Mitochondrial Functions
Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance.
- Trial name
- Mithycal (NCT00446745)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
End-Stage Renal Disease, Dialysis
Effects of N-acetylcysteine on Muscle Fatigue in Hemodialysis
The purposes of the study are to determine whether oxidative stress causes the muscle of dialysis patients to tire more quickly than muscle of people without kidney disease and to determine whether treatment with…
- Conditions
- End-Stage Renal Disease, Dialysis, Hemodialysis
- Trial name
- NAC (NCT00440869)
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Knee Osteoarthritis (Knee OA)
Muscle Isometric Contraction for the Treatment of Knee Osteoarthritis
This study compares the effects of three different intensities of Muscle Isometric Contraction (MIC) on balance ability, proprioception, muscle strength, KOA symptoms, and inflammatory factors in synovial fluid among elderly…
- Trial name
- KOA (NCT06870656)
- Testing
- Low-intensity group, Medium-intensity group, High-intensity group
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chengdu Sport University
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Fibromyalgia, Whiplash
Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain
Diffuse noxious inhibitory control In order to quantify central sensitization in chronic pain patients, the Diffuse Noxious Inhibitory Control (DNIC) model has been used frequently.
- Conditions
- Fibromyalgia, Whiplash, Chronic Pain
- Trial name
- NCT01172795
- Testing
- Relaxation session, Neurocognitive test battery
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Diabetes, Obesity
Mitochondrial Impairment in Muscle Insulin Resistance
This investigation is being carried out to learn more about research findings from a study that was completed last year. Those findings revealed that within the skeletal muscle cells of individuals with type 2 diabetes, there was…
- Trial name
- NCT00222924
- Testing
- weight loss/ exercise
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
CVD
EEG/MECG/EMG Evaluating the Severity of Aortic Stenosis, Heart Failure and Ischemic Stroke Through an Artificial Intelligenceassisted System.
The specific objectives and methods of this project are: (1) To test the feasibility and accuracy of integrating EEG, MECG and EMG for detecting the severity of diseases such as aortic stenosis, heart failure and ischemic stroke.
- Trial name
- NCT05716659
- Where
- Taiwan
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Spinal Muscular Atrophy (SMA), Spinal Muscular Atrophy Type I
Psychological Evaluation of the Parental Experience of Newborn Screening for Infantile Spinal Muscular Atrophy in the Grand Est and Nouvelle-Aquitaine Regions
The systematic inclusion of spinal muscular atrophy (SMA) in France's neonatal genetic screening (NGS) program, scheduled for September 2025, represents a major milestone in public health.
- Trial name
- PSYSMA (NCT07208903)
- Testing
- focus group discussions, Interview with the psychologist
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Fibromyalgia
Effectiveness of Pain Neuroscience Education and Strength Training in Fibromyalgia
The main goal of this study is to get to know if applying both, pain neuroscience education (PNE) plus strength training (ST) will reduce the pain of fibromyalgia (FM).
- Trial name
- PNE-ST-FM (NCT04855851)
- Testing
- PAIN NEUROSCIENCE EDUCATION AND STRENGTH TRAINING, USUAL CARE
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Manuel Rebollo Salas
Muscle Loss
The Viscoelastic Properties of Lower Extremity's Muscles
This study aims to create normative values for stiffness, tonus and elasticity in the lower extremity muscles and to determine age and gender differences.
- Trial name
- NCT04289129
- Testing
- Myotonometric evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Anaphylaxis
Study to Explore the Pharmacokinetics and Pharmacodynamics of Epinephrine in Healthy Male and Female Subjects With Different Skin to Muscle Depth (STMD)
A single dose, open label, randomized cross-over study to explore the pharmacokinetics and pharmacodynamics of epinephrine in healthy male and female subjects
- Trial name
- NCT03282929
- Testing
- Part 1, Part 2 Group 1, Part 2 group 2
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Spinal Muscular Atrophy
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067) Given by Mouth in Healthy Volunteers
The objective of this study is to assess the safety and tolerability of Risdiplam (RO7034067) in healthy people. The study will assess what the body does to Risdiplam (RO7034067) and what Risdiplam (RO7034067) does to the body.
- Trial name
- NCT02633709
- Testing
- Itraconazole, Risdiplam
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Pelvic Girdle Pain, Diastasis Recti and Weakness of the Linea Alba
The Association Between Pelvic Floor Muscle Function, Diastasis Recti and Postpartum Pelvic Girdle Pain - a Matched Case Control Study.
Background: Pregnancy-related pelvic girdle pain (PGP) can appear during pregnancy, directly after labour or can be delayed to 3 weeks postpartum.
- Conditions
- Pelvic Girdle Pain, Diastasis Recti and Weakness of the Linea Alba, Pelvic Floor Disorders
- Trial name
- NCT04757077
- Where
- Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Żelazna Medical Centre, LLC
Diabetes, Obesity
Multi-Tracer PET Quantitation of Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus
The purpose of this research is to use a recently developed triple-tracer positron emission tomography (PET) method to study skeletal muscle insulin resistance.
- Trial name
- NCT00222781
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
No Condition, Healthy Individuals
Protein Intake Distribution to Support Muscle Anabolism in Healthy Young Adults
The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.
- Trial name
- NCT07245199
- Testing
- protein intake
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Takayasu Arteritis, Behçet's Disease
Physical and Psychosocial Parameters in Takayasu Arteritis and Behçet's Disease: A Comparative Study With Healthy Controls
Systemic vasculitis refers to a group of rare diseases characterized by inflammation of blood vessel walls, which may cause ischemia and structural damage in various organs.
- Conditions
- Takayasu Arteritis, Behçet's Disease, Healthy Controls
- Trial name
- NCT07276087
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ÖZLEM NUR TOK YAMAN
Depressive Disorder, Major, Diabetic Neuropathies
Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway
To evaluate the effects of multiple oral doses of desvenlafaxine sustained release (DVS SR) and paroxetine on the biotransformation of codeine to morphine in healthy subjects.
- Conditions
- Depressive Disorder, Major, Diabetic Neuropathies, Fibromyalgia, Vasomotor Symptoms
- Trial name
- NCT00456898
- Testing
- desvenlafaxine sustained release (DVS SR), Paroxetine, Codeine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoarthritis
Prehabilitation Physical Activity in Persons With Osteoarthritis
Knee joint osteoarthritis (OA) reduces functional mobility and performance of daily tasks such as rising from a chair. Therefore interventions aimed at improving muscle strength and sit-to-stand task performance are very…
- Trial name
- PrehabOA (NCT02881463)
- Testing
- therapeutical exercises
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Occupational Stress
Progressive Muscle Relaxation Exercise on Intensive Care Nurses
Nurses who intensive care unit will be entered. Participants will be randomized to one of two study arms: Arm 1: Progressive muscle relaxation; Arm 2: control.
- Trial name
- NCT05056571
- Testing
- Progressive muscle relaxation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hip Injuries, Muscular Atrophy
Strength and Strength-ratio of Hip Rotator Muscles at Soccer Players
At this investigation we want to find out whether there is a difference in muscle strength of the internal and external rotation hip muscles between soccer players and non-soccer players caused by typical movement patterns seen…
- Conditions
- Hip Injuries, Muscular Atrophy, Dysfunction
- Trial name
- NCT01821183
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
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