Clinical trials: Muscle Disorders
Joint Pain, Musculoskeletal Pain
IDEA-033 Open Label Study
The main aim of the study is to evaluate safety, efficacy, compliance, and usage of epicutaneously applied IDEA-033 in joint / musculoskeletal pain or soft tissue inflammation.
- Conditions
- Joint Pain, Musculoskeletal Pain, Stiffness, Soft Tissue Inflammation in Designated Target Area(s)
- Trial name
- NCT00372333
- Testing
- IDEA-033
- Where
- Germany
- Volunteers
- 491 people
- Sponsor
- IDEA AG
Dysphagia After Stroke
Enhancing Post-Stroke Dysphagia Rehabilitation
The goal of this clinical trial is to investigate the effects of a combined swallowing intervention (Neuromuscular Electrical Stimulation (NMES) + Neuromuscular Taping (NMT) + swallowing exercises) on swallowing function and…
- Trial name
- Not exist (NCT06887855)
- Testing
- Neuromuscular Electrical Stimulation, Neuromuscular Taping, Swallowing exercise (Expiratory Muscle Strength Training)
- Where
- Qatar
- Volunteers
- 10 people
- Sponsor
- Hamad Medical Corporation
Trigger Finger, Percutaneous A1 Pulley Release
Percutaneous Trigger Finger Release Concomitant Steroid Injection Versus Percutaneous Trigger Finger Release Alone
Background: Percutaneous A1 pulley release is a cost-effective and straightforward procedure with outcomes comparable to open A1 pulley release. Postoperative pain is a prevalent concern.
- Conditions
- Trigger Finger, Percutaneous A1 Pulley Release, Steroid Injection, Postoperative Pain
- Trial name
- NCT06288685
- Testing
- percutaneous A1 pulley release, Triamcinolone
- Where
- Thailand
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Police General Hospital, Thailand
Dermatomyositis
Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis
This study will assess the safety and efficacy of topical ruxolitinib for treating the refractory cutaneous manifestations in patients with dermatomyositis.
- Trial name
- NCT06857240
- Testing
- Ruxolitinib Topical Cream
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Cleveland Clinic
Spinal Cord Injury
Oral Colecalciferol Treatment in Spinal Cord Lesion
Low vitamin D is frequently seen in patients with spinal cord injury (SCI) in acute and chronic periods. Among its causes are insufficient sun exposure, limited oral intake, obesity, the effect of the drugs used on the absorption…
- Trial name
- NCT04400747
- Testing
- Vitamin D3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Amyotrophic Lateral Sclerosis, Kennedy Disease
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS), is a rapidly progressive neurodegenerative disorder, usually leading to death from respiratory failure in 3-5 years.
- Trial name
- CERMALS (NCT05107349)
- Testing
- Muscle biopsy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fibromyalgia
Cognitive Behavioral Therapy Trial in Fibromyalgia
Previous studies have shown that the disorder fibromyalgia often is preceded by long-term stress. Moreover, an association has been shown between stress, pain and co-morbidity in these patients.
- Trial name
- (FIBCOG) (NCT01004458)
- Testing
- Cognitive behavioral therapy, Waiting list
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Uppsala University
Pulmonary Disease, Chronic Obstructive, Breathing Exercises
Effects of an Exercise Rehabilitation Programme With a Nasal Inspiratory Restriction Device in COPD Patients
This study evaluates the effects of a nasal restriction device for inspiratory muscle training (FeelBreathe) after 8 weeks of exercise intervention on exercise capacity, quality of life, dyspnea and inspitarotory muscle strength…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Breathing Exercises, Exercise Tolerance
- Trial name
- EPOC_2_0 (NCT03936348)
- Testing
- Exercise training program with and without FB
- Volunteers
- 16 people
- Sponsor
- University of Cadiz
Inclusion Body Myositis
Molecular Profile of the Evolution of Inclusion Body Myositis
This study aims at assessing the gene expression in the muscles of patients suffering from sporadic Inclusion Body Myositis (sIBM) at various stages of the disease, by comparison with muscles of control subject.
- Trial name
- IBM-RNAseq (NCT03299335)
- Testing
- Blood collection
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Polymyalgia Rheumatica (PMR)
Study of Tocilizumab to Treat Polymyalgia Rheumatica
This is a fifteen-month open label, Phase IIa clinical trial is being conducted to assess the tolerability, safety and efficacy of a medication called Tocilizumab (Actemra®) in patients with polymyalgia rheumatica (PMR).
- Trial name
- NCT01396317
- Testing
- Tocilizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hospital for Special Surgery, New York
Sarcopenia
Omega-3 Supplementation in Cervix Cancer Patients Undergoing Chemoradiotherapy
Cancer cachexia is a complex metabolic process affecting up to 80% of patients suffering from an advanced-stage cancer. Moreover, 20 to 40% of all cancer deaths are caused directly by cachexia.
- Trial name
- NCT02779868
- Testing
- Omega-3, Olive oil
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Brazilian National Cancer Institute
Urinary Incontinence, Urinary Incontinence, Stress
Pelvic Floor Rehabilitation Programme for Women With Urinary Incontinence in a Peruvian Public Hospital
This study evaluates whether a 12-week pelvic floor rehabilitation programme improves urinary incontinence symptoms in adult women treated at Hospital Nacional Edgardo Rebagliati Martins, a public tertiary hospital in Lima, Peru.
- Conditions
- Urinary Incontinence, Urinary Incontinence, Stress, Urinary Incontinence, Urge, Mixed Urinary Incontinence
- Trial name
- NCT07858968
- Testing
- Supervised group pelvic floor muscle training, Individual physiatrist-led pelvic floor sessions
- Where
- Peru
- Volunteers
- 89 people
- Sponsor
- Hospital Nacional Edgardo Rebagliati Martins
Osteogenesis Imperfecta
Effects of a Physical Rehabilitation Program Using the Nintendo Wii on Children With Osteogenesis Imperfecta (OI)
Children with osteogenesis imperfecta are described as extremely sedentary and therefore fatigable, which strongly impacts their daily activities.
- Trial name
- NCT02542540
- Testing
- Training with Nintendo Wii console
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
FSHD - Facioscapulohumeral Muscular Dystrophy
Ten Year Follow-up in FSHD: the FOCUS 3 Study
This study aims to assess longitudinal data in 170 adult and 30 pediatric genetically and clinically well-defined facioscapulohumeral dystrophy (FSHD) patients.
- Trial name
- FSHD-FOCUS 3 (NCT06911190)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Ledderhose Disease
Ledderhose Disease: Radiotherapy or Not?
The aim of the LedRad trial is to determine the efficacy and durability of radiotherapy as treatment for patients with Ledderhose disease and to compare this to the natural course of Ledderhose disease.
- Trial name
- LedRad (NCT03507010)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- University Medical Center Groningen
Achilles Tendinitis, Right Leg, Achilles Tendinitis
Autologous Stem Cells in Achilles Tendinopathy
This study is looking at a new treatment, using the patient's own stem cells (the repair cells of the body), to see whether this can help reduce pain and promote healing of the Achilles tendon, without side effects.
- Conditions
- Achilles Tendinitis, Right Leg, Achilles Tendinitis, Achilles Degeneration, Achilles Tendon Thickening
- Trial name
- ASCAT (NCT02064062)
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Chronic Fatigue Syndrome, Fibromyalgia
Compare the Medical Conditions of Gulf War Veterans to Non-Deployed Veterans
Primary Hypothesis: Gulf War veterans will have an equal prevalence or mean level of the following medical and psychological conditions frequently reported in the literature compared to a control group of nondeployed veterans…
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Post-Traumatic Stress Disorder, Neurologic Abnormalities
- Trial name
- NCT00032461
- Volunteers
- 2,000 people
- Sponsor
- US Department of Veterans Affairs
Parkinson's Disease, Foot Dystonia
Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles)
Foot dystonia is frequently observed in patients suffering from Parkinson'disease. It is characterized by an abnormal involuntary movement which is very uncomfortable (difficult to walk) and painful for the patient.
- Trial name
- RBHP 2008 (NCT00909883)
- Testing
- Botulinum Toxin: Xeomin
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Duchenne Muscular Dystrophy (DMD)
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-251 in Participants With Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping
The primary purpose of this study is to evaluate the safety, tolerability, and dystrophin protein levels in muscle tissue following multiple intravenous (IV) doses of DYNE-251 in participants with Duchenne muscular dystrophy…
- Trial name
- DELIVER (NCT05524883)
- Testing
- DYNE-251
- Where
- 30 sites in United States, Australia and 7 more
- Volunteers
- 86 people
- Sponsor
- Dyne Therapeutics
Supraspinatus Tear or Rupture, Not Specified as Traumatic
Ultrasound of Supraspinatus Muscle Tears
The supraspinatus is a relatively small muscle of the upper back that runs from the supraspinatus fossa superior portion of the scapula to the greater tubercle of the humerus.
- Trial name
- NCT03171883
- Volunteers
- 30 people
- Sponsor
- Assiut University
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