Clinical trials: Muscle Function
Muscle Function
Female Muscle Enhancement
Participating in regular physical activity has been shown to reduce the risk of developing some diseases and disabilities that can occur with ageing.
- Trial name
- FemME (NCT05397418)
- Testing
- Supervised resistance exercise program, Unsupervised resistance exercise program
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Vitamin D Deficiency, Immune Health
Estimation of the Dietary Requirement for Vitamin D in Ethnic Groups
The aim of this study is to perform a double-blind, randomised, dose-response trial of vitamin D3 supplementation in United Kingdom (UK)-dwelling adults of white European, South Asian, and black African/Caribbean ethnicity to…
- Conditions
- Vitamin D Deficiency, Immune Health, Muscle Function
- Trial name
- NCT06067477
- Testing
- Vitamin D Supplement
- Where
- United Kingdom
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Dementia, Gait
Fine and Gross Motor Function and Relationship With Muscle Tone in Older Adults With and Without Dementia
The purpose of this study was (1) to investigate changes in gait, balance, fine motor function, and muscle tone, and (2) to find out if there is a correlation between muscle tone/presence of paratonia and motor function (gross…
- Conditions
- Dementia, Gait, Balance, Muscle Tone
- Trial name
- NCT03479567
- Testing
- Gait accelerometry, balance accelerometry, Fine motor skill test
- Where
- Belgium
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University Ghent
Muscle Function
Muscle in Obesity: Imaging, Function and microRNA
Growing evidence suggests that dynapenic abdominal obesity is associated with a greater risk of falls, functional disability and hospitalisation compared to those with dynapenia, obesity or neither phenotype.
- Trial name
- NCT04300504
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Cystic Fibrosis, Muscle Strength
Muscle Strength, Functional Capacity, Respiratory Function and Quality Of Life In Cystic Fibrosis Patients
This study was designed to investigate the relationship between upper extremity muscle strength and endurance, functional capacity, and quality of life child and adolescent with cystic fibrosis
- Conditions
- Cystic Fibrosis, Muscle Strength, Pulmonary Function, Functional Capacity
- Trial name
- NCT04734743
- Testing
- cystic fibrosis
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cagtay Maden
Disuse Atrophy (Muscle) of Lower Extremities, Muscle Function
The Impact of Bed Rest, Aging and NMES on Skeletal Muscle
Loss of muscle mass is common phenotypic trait of muscular disuse and ageing. The loss of muscle mass affects, among others, the ability to maintain homeostasis of glucose metabolism and the energy reservoir in catabolic…
- Conditions
- Disuse Atrophy (Muscle) of Lower Extremities, Muscle Function, Neuromuscular Electrical Stimulation, Myofibrillar Protein Synthesis
- Trial name
- NCT05617222
- Testing
- Bed rest, Neuromuscular electrical stimulation
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Aging, Mitochondrial Dysfunction
A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects
Part A: The study is a double-blind, randomized, single ascending doses, study in 24 healthy elderly male and female volunteers. Each subject will be randomized for two subsequent doses in three cohorts.
- Conditions
- Aging, Mitochondrial Dysfunction, Muscle Function
- Trial name
- NCT02655393
- Testing
- Mitopure
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Mitochondrial Function, Bioenergetics, Muscle Function
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
This is a randomized, double-blind, single-center, placebo-controlled Phase 2 trial enrolling 66 healthy elderly subjects (33 placebo and 33 AMAZ-02 administration) who are ≥65 and ≤ 90 years of age with evidence of low…
- Conditions
- Mitochondrial Function, Bioenergetics, Muscle Function, Aging
- Trial name
- NCT03283462
- Testing
- Mitopure
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Muscle Function, Mitochondrial Function, Overweight
AMAZ-02 Effect on Exercise ToLerance in Healthy, Overweight Middle Aged Subjects (ATLAS Trial)
This is a Phase 2 randomized, double-blind, placebo-controlled study enrolling 90 healthy, overweight, middle aged subjects (30 placebo, 30 low dose and 30 high dose AMAZ-02 intervention), 40-65 years of age, who are otherwise…
- Conditions
- Muscle Function, Mitochondrial Function, Overweight, Healthy Aging
- Trial name
- ATLAS (NCT03464500)
- Testing
- Mitopure 500mg, Mitopure 1000mg
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Amazentis SA
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Muscle Soreness, Exercise
Effects of Delayed Muscle Pain on Respiratory Muscle Function
The aim of the study was to determine whether delayed-onset muscle soreness (DOMS) in trunk muscles has an effect on respiratory function parameters, respiratory muscle strength, respiratory muscle endurance, and exercise…
- Conditions
- Muscle Soreness, Exercise, Respiratory Muscles, Respiratory Function Tests
- Trial name
- NCT05276986
- Testing
- DOMS protocol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Hamstring Muscles, Muscle Function
Effect of Exercises on Hamstring Muscle Function, Injury Risk, Agility and Cognitive Function
Hamstring muscle injuries (HMI) occurs frequently during excessive motions of the physiologic capability of these muscles. It is reported in the literature that impairments in muscle architecture, such as a decrease in the…
- Conditions
- Hamstring Muscles, Muscle Function, Cognitive Function, Turkish Get Up
- Trial name
- NCT04563611
- Testing
- Turkish Get-up exercise, Askling L-Protocol, Nordic hamstring exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Respiratory Muscle, Pulmonary Function Test
Ultrasonographic Evaluation of Respiratory Muscles in Stroke Patients
Ultrasonographic evaluation of respiratory muscle thickness in stroke patients, determination of its correlation with pulmonary function test (PFT) , and the first evaluation method to determine respiratory rehabilitation goals…
- Trial name
- NCT05093491
- Testing
- Spirometry and ultrasonography in stroke group, Spirometry and ultrasonography in healthy group
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Systemic Lupus Erythematosus, Muscle Pain
Laser Therapy for Patients With Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease that has detrimental effects on connective tissue and other organs.
- Conditions
- Systemic Lupus Erythematosus, Muscle Pain, Chewing Function
- Trial name
- NCT04453215
- Testing
- GaAlAs semiconductor diode laser device
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Dr. Merve Benli
Fat-free Masss, Muscle Strength
Effects of Fish Oil and Resistance Training on Muscle Mass and Function
This study consists of a free-living, 6-week fish oil (FO) or placebo (PLA) supplementation intervention alongside participants' habitual resistance exercise training (RET) regimens.
- Conditions
- Fat-free Masss, Muscle Strength, Neuromuscular Function
- Trial name
- NCT04245332
- Testing
- Fish oil, Coconut oil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rowan University
Effect of Omega-3 Supplementation on Exercise Performance and Muscle Tissue Functions
Omega-3 Supplementation Combined With Endurance Training Improve Running Economy in Recreational Runners.
Recreational male runners participated in 12 weeks training and omega-3 supplementation programme. Before starting and at the end of the 12-week cycle, the runners performed an increasing intensity treadmill test where oxygen…
- Trial name
- NCT04780451
- Testing
- Omega-3 supplementation in recreational runners
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Quadriceps Muscle Function
Central and Peripheral Changes in Quadriceps Femoris Function After Different Types of Isometric Strength Training
The purpose of this investigation is to examine the effects of 6-week unilateral isometric training interventions over quadriceps femoris on maximal strength and RFD-SF parameters and cortical excitability.
- Trial name
- NCT04624438
- Testing
- Isometric training with electromyostimulation, Isometric training with voluntary activation, Isometric training with combination of electromyostimulation and voluntary activation
- Where
- Serbia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Bone Health, Muscle Function
Effects of Milk Protein and Vitamin D on Children's Growth and Health
The purpose of D-pro is to investigate the combined and separate effects of milk protein and vitamin D on bone health, growth, muscle function, body composition and cardiometabolic health in 6-8-year-old children.
- Conditions
- Bone Health, Muscle Function, Cardiometabolic Health, Appetite Regulation
- Trial name
- D-pro (NCT03956732)
- Testing
- Milk Protein (high), Vitamin D, Milk Protein (medium)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Impaired Mitochondrial Function, Muscle Performance
Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men
As people grow older skeletal muscle gradually becomes smaller and weaker, causing reduced mobility and quality of life. To understand and reverse this negative process investigators need to find new ways of improving the ability…
- Trial name
- Rejuvenate (NCT02792621)
- Testing
- Acipimox
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust