Clinical trials: Muscle Loss
Trapezius Muscle Atrophy
Trapezius Muscle Activities in the Natural Head Posture and Corrected Head Posture During Wall-Slide Exercise
The goal of this observational study is to investigate the effect of head posture on trapezius muscle activity and ratios during wall slide exercise.
- Trial name
- NCT06872957
- Testing
- Surface Electromyography Noraxon MiniDTS system
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Weight Loss, Muscle Loss
Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency
Military personnel face many physiological challenges, including sustained physical activity and prolonged periods of negative energy balance.
- Conditions
- Weight Loss, Muscle Loss, Bone Loss
- Trial name
- NCT01292395
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Sarcopenia, Frailty
Whole Grain Job's Tear, Muscle Health, Blood Glucose and Lipid Level
Background: This investigation aims to explore efficacy of Taiwanese whole grain job's tear on muscle health and blood glucose and lipid levels in community-dwelling older adults.
- Conditions
- Sarcopenia, Frailty, Hyperglycemia, Hyperlipidemia
- Trial name
- NCT06503172
- Testing
- Taiwanese whole grain job's tear (red job's tear), White job's tear
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Sarcopenia
Screening for Age-Related Skeletal Muscle Dysfunction
This pilot study will aid the development of a sonographic screening method used to obtain proxy measures of LBM and estimates of muscle composition that relate to Intramuscular adipose tissue (IMAT), lipid metabolism, and…
- Trial name
- ARMS (NCT02277236)
- Testing
- DXA scanning, CT imaging
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Frailty, Sarcopenia
Development of Frailty Prevention Clinic in Geriatric Comprehensive Clinic RSCM:
There is an increasing number of elderly population, not only in Indonesia, but also in the world. With increasing of age, there is also an increasing number of elderly with sarcopenia and frailty.
- Conditions
- Frailty, Sarcopenia, Resistance Training
- Trial name
- NCT05511311
- Testing
- Resistance Training, Standard Therapy
- Where
- Indonesia
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Sarcopenia, Body Weight Changes
Effects of Resistance Training on Physical Performance, Health and Quality of Life in Elderly (RTCHealth)
Physical exercise is considered an important intervention for promoting well-being and healthy aging. The purpose of the present study was to determine the effects of moderate-to-high intensity resistance training circuit on…
- Conditions
- Sarcopenia, Body Weight Changes, Quality of Life
- Trial name
- RTCHealth (NCT03551132)
- Testing
- Exercise test
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Sarcopenia
Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect…
- Trial name
- NCT01477164
- Testing
- High intensity aerobic exercise, Resistance exercise training, Combined
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes, Muscle Atrophy
The Role of Type 2 Diabetes on Skeletal Muscle Atrophy and Recovery Following Bed Rest in Older Adults
The goal of this study is to determine the impact of pre-diabetes and type 2 diabetes on muscle atrophy during a period of bed rest and recovery of muscle mass, strength, and physical function following bed rest.
- Conditions
- Type 2 Diabetes, Muscle Atrophy, Aging, Sedentary Behavior
- Trial name
- REST (NCT03761446)
- Testing
- Bed rest
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Sarcopenia
Muscle Capillarization and Sarcopenia
Aging is associated with a loss of muscle mass, termed sarcopenia, that reduces mobility, decreases physical function and accelerates progression of other age-related disorders.
- Trial name
- NCT03984994
- Testing
- Aerobic exercise training, Strength training
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baltimore VA Medical Center
Obesity, Muscle Loss
The POWER BARIATRIC Trial: Physical Outcomes With Exercise Regimens on BARIATRIC Patients
This study aims to determine how different types of exercise regimens (resistance, aerobic, or combined exercise regimens) can be used to minimize muscle loss and mobilize body fat in severely obese patients after bariatric…
- Conditions
- Obesity, Muscle Loss, Adiposity
- Trial name
- POWER (NCT04777305)
- Testing
- Physical activity training
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Sarcopenia
Efficacy of Nutritional Supplementation on Physical-activity Mediated Changes in Physical Functioning Older Adults at Risk for Mobility Disability (The VIVE2 Study)
Several trials have found that nutritional supplementation can elicit an increased rate of skeletal muscle protein synthesis following a single bout of exercise in both young and older individuals.
- Trial name
- NCT01542892
- Testing
- Exercise Intervention, Supplement Intervention
- Where
- 2 sites in United States, Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tufts University
Osteoporosis, Sarcopenia
Effect of Creatine Supplementation and Exercise on Bone Health
Osteoporosis is an important health problem, costing the Canadian health care system over $2 billion per year. Loss of bone mineral and bone fragility is especially prevalent in postmenopausal women.
- Trial name
- NCT02047864
- Testing
- Creatine monohydrate
- Where
- 2 sites in Canada
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Muscle Loss
Galactooligosaccharide and Aging
Sarcopenia is a progressive muscle disease, most commonly affecting older individuals, that is categorised by 1) low muscle strength, 2) low muscle quantity or quality, and 3) low physical performance.
- Trial name
- NCT06411964
- Testing
- Prebiotic
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Sarcopenia
Dietary Supplements and Aging Muscle
The purpose of this study is to determine whether older adults (ages 65-89) who consume the dietary supplement Juven (Abbott Laboratories) versus placebo for 6 months will demonstrate increases in fat-free mass, muscle volume,and…
- Trial name
- NCT01057082
- Testing
- Juven
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Sarcopenia
Determining the Muscle Anabolic Properties of Phosphatidic Acid.
Ageing is characterized by a loss of muscle mass that is detrimental for physical function and metabolic health and increases the risk of mortality.
- Trial name
- PA-AGE (NCT03446924)
- Testing
- Phosphatidic Acid, Rice flour
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Older Adults Without Any Specific Clinical Condition
Essential Amino Acid Supplementation Enhances Post-prandial Amino Acid Availability Following a Standard-protein Breakfast in Older Adults
Healthy older adults and those who have acute and chronic conditions suffer from reduced protein intake and are at risk of developing both chronic and acute sarcopenia.
- Trial name
- NCT07754760
- Testing
- Essential amino acid supplement
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Preventing Age-Related Muscle Loss: the Role of Exercise in Improving Strength, Function, and Well-being
Muscle Aging Evaluation
This study aims to assess the effects of physical activity in counteracting muscle aging. The increasing life expectancy worldwide has led to a rise in age-related muscle decline, which negatively impacts strength, function, and…
- Trial name
- NCT06845748
- Testing
- Physical activity Group
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Milan
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Sarcopenia
Morphological and Functional Biomarkers of Skeletal Muscle Adaptations in Sarcopenia
Sarcopenia is an age-related condition characterized by progressive loss of skeletal muscle mass, muscle strength, and physical performance.
- Trial name
- EXEDOS (NCT07692308)
- Testing
- Digitally delivered home-based exercise intervention, General physical activity recommendations
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Libido, Receptors, Androgen
Genetic Polymorphism of the Androgen Receptor-Gene and Sexual Function in Middle Aged Women
It is known that with increasing age sexual desire is declining in women. Decreasing levels of androgens are believed to have an influence, but cannot explain the loss of libido completely.
- Conditions
- Libido, Receptors, Androgen, Polymorphism, Genetic, Androgen Effect
- Trial name
- CAG-Libido (NCT01977313)
- Where
- Switzerland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern